Curcumin inhibits the classical and the alternate pathways of complement activation.

Abstract:

:Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and QurNa, respectively) and the vaccinia virus complement control protein (VCP). The comparative study indicated that CurNa inhibited the classical complement pathway dose dependently (IC50 = 404 microM). CurNa was more active than RANa, but less active than QurNa. VCP was about 2,212, 2,786, and 4,520 times more active than QurNa, CurNa, and RANa, respectively. Further study revealed that CurNa dose dependently inhibited zymosan-induced activation of the alternate pathway of complement activation.

journal_name

Ann N Y Acad Sci

authors

Kulkarni AP,Ghebremariam YT,Kotwal GJ

doi

10.1196/annals.1352.007

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

100-12

eissn

0077-8923

issn

1749-6632

pii

1056/1/100

journal_volume

1056

pub_type

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