Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients.

abstract：UNLABELLED:A new Biorex molecule, BRX-220, has been shown to be effective in animal models of diabetic neuro- and retinopathy. Recent in vitro studies showed that it might also have an insulin-sensitizing action. Therefore, the effect of BRX-220 on insulin sensitivity was compared with the action of pioglitazone (PGZ) ...

journal_title：Annals of the New York Academy of Sciences

authors： Seböková E,Kürthy M,Mogyorosi T,Nagy K,Demcáková E,Ukropec J,Koranyi L,Klimes I

更新日期：2002-06-01 00:00:00

abstract：:We have studied the developmental patterns of vasoactive intestinal polypeptide (VIP) binding sites in the human hypothalamus. VIP recognition sites were widely distributed throughout the rostrocaudal extent of the hypothalamus. VIP binding was generally low in the fetal and neonatal periods and a tendency in increasi...

journal_title：Annals of the New York Academy of Sciences

authors： Najimi M,Rachidi F,Afif A,Chigr F

更新日期：2006-07-01 00:00:00

abstract：:Heart disease is the leading cause of death in the industrialized world. This is partially attributed to the inability of cardiomyocytes to divide in a significant manner, and therefore the heart responds to injury through scar formation. One of the challenges of modern medicine is to develop novel therapeutic strateg...

journal_title：Annals of the New York Academy of Sciences

authors： Bolli P,Chaudhry HW

更新日期：2010-11-01 00:00:00

abstract：:The results of a series of experiments aimed at directly comparing the prosodic level of processing in language with the melodic level of processing in music are reported. The first series of experiments was conducted on adults, musicians and nonmusicians, and the second one on 7- to 9-year-old musician and nonmusicia...

journal_title：Annals of the New York Academy of Sciences

authors： Magne C,Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:Red spruce (Picea rubens Sarg.) and balsam fir (Abies balsamea (L.) Mill.) were present by 13,700 years B.C.E. in the Catskills Mountains of southeastern New York State. These conifers were, and still are, largely confined to the eastern and far western portions of the region. A gap in the distribution exists between ...

journal_title：Annals of the New York Academy of Sciences

authors： Kudish M

更新日期：2013-09-01 00:00:00

abstract：:A complete amino acid sequence for rat testis P-450 17 alpha was deduced from nucleotide analysis of a cDNA clone isolated from a rat Leydig cell library. This cDNA expressed in COS-1 cells both 17 alpha-hydroxylase and 17,20 lyase activities. Rat P-450 17 alpha exhibited significant similarity to the nucleotide and d...

journal_title：Annals of the New York Academy of Sciences

authors： Dufau ML,Minegishi T,Buczko E,Kitamura M,Delgado C,Namiki M

更新日期：1989-01-01 00:00:00

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:Estrogen has clearly been shown to decrease bone loss and frequency of osteoporotic fractures. Calcitonin has been shown in several studies to reduce the rate of bone loss, although no data are yet available demonstrating a reduction in fracture frequency. Studies of osteoporosis intrinsically assume that prevention o...

journal_title：Annals of the New York Academy of Sciences

authors： Lindsay R,Cosman F

更新日期：1990-01-01 00:00:00

abstract：:High concentrations of glucose induce insulin resistance and impair insulin secretion in a manner that mirrors type 2 diabetes, a phenomenon known as glucose toxicity. High concentrations of hexosamines mimic these effects, leading to the hypothesis that cells use hexosamine flux as a glucose- and satiety-sensing path...

journal_title：Annals of the New York Academy of Sciences

authors： Cooksey RC,McClain DA

更新日期：2002-06-01 00:00:00

abstract：:Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein...

journal_title：Annals of the New York Academy of Sciences

authors： Goodman DS

更新日期：1981-02-27 00:00:00

abstract：:Myasthenia gravis (MG) is usually caused by autoantibodies against muscle nicotinic acetylcholine receptor (AChR), which is composed of five subunits (alpha(2)betagammadelta or alpha(2)betaepsilondelta). Current treatments, including plasmapheresis, are nonspecific, causing several side effects. We aim to develop an a...

journal_title：Annals of the New York Academy of Sciences

authors： Tzartos SJ,Bitzopoulou K,Gavra I,Kordas G,Jacobson L,Kostelidou K,Lagoumintzis G,Lazos O,Poulas K,Sideris S,Sotiriadis A,Trakas N,Zisimopoulou P

更新日期：2008-01-01 00:00:00

abstract：:The benefits of estrogen replacement therapy in postmenopausal women include increased quality of life, relief from specific symptoms, and the prevention of osteoporosis, genitourinary atrophy, and cardiovascular diseases. Despite these advantages, this therapy has been reported to be associated with an increased freq...

journal_title：Annals of the New York Academy of Sciences

authors： De Cecco L,Leone M,Gerbaldo D,Venturini PL,Rissone R,Messeni Leone M

更新日期：1991-01-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While the mechanism of this protection has largely been thought to be due to their chaperone functions (i.e., preventing abnormal pro...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Liu J,Zheng Z,Vexler ZS,Lee JE,Giffard RG

更新日期：2005-08-01 00:00:00

abstract：:Basic fibroblast growth factor is a polypeptide belonging to a family of natural proteins also known as heparin-binding growth factors endowed with a pleiotropism of biological activities, the most striking of which are related to wound healing. Large quantities of recombinant human basic fibroblast growth factor (rh-...

journal_title：Annals of the New York Academy of Sciences

authors： Mazué G,Bertolero F,Jacob C,Sarmientos P,Roncucci R

更新日期：1991-01-01 00:00:00

abstract：:A permanent decrease was seen in the prevalence of lice infestation among population of the Ukraine from 1990-2004. The prevalence of lice infestation among children under 14 years of age was 6-27 times more than that in adults. The highest figures were among children 7-14 years old. During all of the observation peri...

journal_title：Annals of the New York Academy of Sciences

authors： Kurhanova I

更新日期：2006-10-01 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is an ubiquitously present extracellular lipid mediator that is released by several cell types, particularly by activated platelets. The effects of S1P are mediated by a specific family of G protein-coupled sphingosine 1-phosphate receptors (S1P1-S1P5). We demonstrate that S1P acts on hem...

journal_title：Annals of the New York Academy of Sciences

authors： Seitz G,Boehmler AM,Kanz L,Möhle R

更新日期：2005-06-01 00:00:00

abstract：:Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these recep...

journal_title：Annals of the New York Academy of Sciences

authors： Myslivecek J,Tillinger A,Novakova M,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

journal_title：Annals of the New York Academy of Sciences

authors： Azimov D,Bishop R

更新日期：2005-12-01 00:00:00

abstract：:Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

journal_title：Annals of the New York Academy of Sciences

authors： Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

更新日期：2003-06-01 00:00:00

abstract：:Several orphan G-protein-coupled receptors (GPCRs), LGR7 and LGR8, GPCR135 and GPCR142, were recently identified as putative, native receptors for different relaxin-family peptides, and their cell signaling mechanisms were elucidated in stably transfected cell lines. Anatomic studies have demonstrated that discrete po...

journal_title：Annals of the New York Academy of Sciences

authors： Ortinau S,Lin F,Wade JD,Tregear GW,Bathgate RA,Gundlach AL

更新日期：2005-05-01 00:00:00

abstract：:Normal human mitotic cells do not proliferate indefinitely in culture but undergo a limited number of divisions and progressively reach a state of irreversible growth arrest, a process termed replicative senescence. Hypoxia is a situation of reduced oxygen concentration that relates to many physiological and pathophys...

journal_title：Annals of the New York Academy of Sciences

authors： Poulios E,Trougakos IP,Chondrogianni N,Gonos ES

更新日期：2007-11-01 00:00:00

abstract：:The New York Stem Cell Foundation's "Fifth Annual Translational Stem Cell Research Conference" convened on October 12-13, 2010 at the Rockefeller University in New York City. The conference attracted over 400 scientists, patient advocates, and stem cell research supporters from 16 countries. In addition to poster and ...

journal_title：Annals of the New York Academy of Sciences

authors： Marshall C,Wang GK,Cimetta E,Talchai C,Egli D,Shim JW,Martin I,Ahmad F,Sproul A,Chen T,Fossati V,McKeon D,Smith K,Solomon SL

更新日期：2011-05-01 00:00:00

abstract：:Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation. Genetically engineered murine mode...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholson AC,Han J,Febbraio M,Silversterin RL,Hajjar DP

更新日期：2001-12-01 00:00:00

abstract：:The nature and regulation of juvenile hormone (JH) biosynthesis have been investigated in isolated corpora allata (CA) of adult males and females, and larvae of the tomato moth Lacanobia oleracea (Noctuidae). Larval CA (Vth day 1 to VIth day 1) appear to synthesize JH at very low rates (< 0.5 fmol/pr/h). This synthesi...

journal_title：Annals of the New York Academy of Sciences

authors： Audsley N,Weaver RJ,Edwards JP

更新日期：1999-01-01 00:00:00

abstract：:Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects are assessed in the rat during the first month of life, regarding both ...

journal_title：Annals of the New York Academy of Sciences

authors： Gomes-DA-Silva J,Silva MC,Tavares MA

更新日期：1998-05-01 00:00:00

abstract：:Protein crystallization has been studied in presence or absence of buoyancy-driven convection. Gravity-driven flow was created, or suppressed, in protein solutions by means of vertically directed density gradients that were caused by generating suitable temperature gradients. The presence of enhanced mixing was demons...

journal_title：Annals of the New York Academy of Sciences

authors： Nanev CN,Penkova A,Chayen N

更新日期：2004-11-01 00:00:00

abstract：:In the basal state, patients with sarcoidosis have reduced numbers of circulating T lymphocytes and a normal number of circulating B lymphocytes. The lymphocytes show impaired DNA synthesis in response to several mitogens and antigens and impaired K-cell cytotoxicity. Circulating atypical cells of lymphocytic origin a...

journal_title：Annals of the New York Academy of Sciences

authors： Hedfors E

更新日期：1976-01-01 00:00:00

abstract：:The first recognition of tolerance and partial tolerance to attempted sensitization with simple allergenic chemicals is described. A proper designation would be the Frei-Sulzbeger-Chase phenomenon. Coupling with self occurs in these experiments; there is not only resistance to developing contactant-type sensitivity bu...

journal_title：Annals of the New York Academy of Sciences

authors： Chase MW

更新日期：1982-01-01 00:00:00