Distribution and function of T- and B-cell subpopulations in sarcoidosis.

Abstract:

:Some in vitro functions of purified T and B cells from PPD- and Candida albicans-negative sarcoidosis patients were analyzed. It appears that in those patients there is: 1) A decrease in the absolute number of T lymphocytes and an increase in the number of B cells; 2) a rather normal response of T lymphocytes to PHA and Con A; 3) a rather normal capacity of T and B cells to produce MIF in vitro; and 4) an ability of T cells from sarcoid patients (but not B cells) to produce LMF. These results suggest that the frequent deficit in cell-mediated immunity observed in sarcoidosis seems to correlate with a quantitative deficit in T cells. The cause of this T-cell deficit is unknown.

journal_name

Ann N Y Acad Sci

authors

Fernandez B,Press P,Girard JP

doi

10.1111/j.1749-6632.1976.tb47018.x

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

80-7

eissn

0077-8923

issn

1749-6632

journal_volume

278

pub_type

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