The default network and self-generated thought: component processes, dynamic control, and clinical relevance.

abstract：:Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

journal_title：Annals of the New York Academy of Sciences

authors： Smith CJ,Ajdukiewicz A,Kelleher PC

更新日期：1983-01-01 00:00:00

abstract：:More than 10% of postmenopausal women in the United States receive thyroid hormone replacement therapy and up to 20% of these women are over-replaced inducing subclinical hyperthyroidism. Because hyperthyroidism and post menopausal osteoporosis overlap in women of advancing age, it is urgent to understand the effect o...

journal_title：Annals of the New York Academy of Sciences

authors： Abe E,Sun L,Mechanick J,Iqbal J,Yamoah K,Baliram R,Arabi A,Moonga BS,Davies TF,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:New approaches to the treatment of pulmonary arterial hypertension (PH) have increased symptomatic relief and prolonged survival. PH is a common sequela of the hemoglobinopathies, but the use of standard oral treatment options is limited because of toxicity and poor effectiveness. Sildenafil citrate is a selective and...

journal_title：Annals of the New York Academy of Sciences

authors： Derchi G,Forni GL

更新日期：2005-01-01 00:00:00

abstract：:(a) The PR elicited by excitotoxic destruction of intrinsic neurons in the CN has a rapid onset, peaks within 2 weeks, and persists indefinitely; (b) the majority of the proliferating cells are not intrinsic to the CNS but are of hematic origin; (c) a small mirror-image response is seen in the contralateral CN; (d) th...

journal_title：Annals of the New York Academy of Sciences

authors： Katz IR,Iacovitti L,Reis DJ

更新日期：1988-01-01 00:00:00

abstract：:At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca(2+) concentration, [Ca(2+)](c), depend on at least three efficient regulatory mechanisms: (1) the plasmalemmal Ca(2+) channels; (2) the endoplasmic reticulum (ER); and (3) the mitochondria. High-voltage activated Ca(2+) channels of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Cuchillo-Ibanez I,Albillos A,Aldea M,Arroyo G,Fuentealba J,Garcia AG

更新日期：2002-10-01 00:00:00

abstract：:Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

journal_title：Annals of the New York Academy of Sciences

authors： Weinstock JV,Elliott D

更新日期：1998-05-01 00:00:00

abstract：:A small but measurable component of some indoor lighting is ultraviolet radiation (UVR); whether it is sufficient to modify the indoor worker's risk for chronic skin changes is not directly answerable with available technology. A first approach to this question involves a) estimating a range of annual background solar...

journal_title：Annals of the New York Academy of Sciences

authors： Cole C,Forbes PD,Davies RE,Urbach F

更新日期：1985-01-01 00:00:00

abstract：:Cardiac development is characterized by a complex interplay of chemical, mechanical, and electrical forces, which together contribute to the proper formation of the heart muscle. In adult myocardium, cardiomyocytes are elongated, well-coupled by gap junctions, and organized in spatially well-defined muscle fibers. Thi...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnappels DA,Gregoire S,Wu SM

更新日期：2010-02-01 00:00:00

abstract：:The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

journal_title：Annals of the New York Academy of Sciences

authors： Mundy NI,Kelly J,Theron E,Hawkins K

更新日期：2003-06-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member...

journal_title：Annals of the New York Academy of Sciences

authors： Allez M,Brimnes J,Shao L,Dotan I,Nakazawa A,Mayer L

更新日期：2004-12-01 00:00:00

abstract：:Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolite...

journal_title：Annals of the New York Academy of Sciences

authors： Mannella CA

更新日期：2008-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or...

journal_title：Annals of the New York Academy of Sciences

authors： Padgett LE,Broniowska KA,Hansen PA,Corbett JA,Tse HM

更新日期：2013-04-01 00:00:00

abstract：:The results of four randomized controlled trials were examined to assess the efficacy of intravenous immunoglobulin (IVIG) for myasthenia gravis (MG) acute exacerbations. The first trial compared plasma exchange (PE) and IVIG in 87 patients. At day 15, the mean change in the Myasthenic Muscular Score (MMS) was 16.6 (9...

journal_title：Annals of the New York Academy of Sciences

authors： Gajdos P,Chevret S

更新日期：2008-01-01 00:00:00

abstract：:I2-imidazoline receptors (I2-IR) are characterized by their high affinity for imidazolines and guanidines and medium affinity for imidazolidines. The differential recognition of I2-IR by amiloride led to subtype these sites as amiloride-sensitive (I2A-IR) and amiloride-insensitive (I2B-IR). I2-IR labeled with [3H]idaz...

journal_title：Annals of the New York Academy of Sciences

authors： Olmos G,Alemany R,Boronat MA,García-Sevilla JA

更新日期：1999-06-21 00:00:00

abstract：:Jackson's Personality Research Form E (PRF) was administered to a large, heterogeneous group of adult inpatients with diagnoses of alcohol and/or drug dependence. Cluster analysis of PRF factor scores yielded five distinct patient subtypes: hostile-dependent, cooperative-nonreflective, socially uninvolved, impulsive-u...

journal_title：Annals of the New York Academy of Sciences

authors： Allen JP,Fertig JB,Mattson ME

更新日期：1994-02-28 00:00:00

abstract：:The article summarizes reports on the concurrence of Klinefelter's syndrome (KS) with inflammatory rheumatic diseases, rheumatoid arthritis (RA), juvenile idiopathic arthritis, psoriatic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, systemic sclerosis, mixed connective tissue disease, the anti...

journal_title：Annals of the New York Academy of Sciences

authors： Rovenský J,Imrich R,Lazúrová I,Payer J

更新日期：2010-04-01 00:00:00

abstract：:Calcitonin gene-related peptide has been identified by immunocytochemistry within the thymus of fetal through aged adult mice. Calcitonin gene-related peptide positive nerves are observed from embryonic day 17 throughout the lifespan of the mouse. A sparse cell population positive for CGRP is first observed during the...

journal_title：Annals of the New York Academy of Sciences

authors： Bulloch K,McEwen BS,Diwa A,Radojcic T,Hausman J,Baird S

更新日期：1994-11-25 00:00:00

abstract：:Growth and pubertal disturbances are the commonest endocrinopathies in homozygous thalassemia, accounting for significant morbidity in 70-80% children and adolescents globally. This review focuses on the pathophysiology of the endocrinopathy from a historical perspective and altered natural history induced by better c...

journal_title：Annals of the New York Academy of Sciences

authors： Chatterjee R,Bajoria R

更新日期：2010-08-01 00:00:00

abstract：:Wear particles produced from artificial joint prostheses are known to cause macrophage-monocyte lineage cells to produce proosteoclastogenic cytokines, including tumor necrosis factor (TNF)-alpha. The specific molecular mechanism, however, is not yet known. Bioinformatic analysis showed that the promoter region of TNF...

journal_title：Annals of the New York Academy of Sciences

authors： Minematsu H,Shin MJ,Celil Aydemir AB,Seo SW,Kim DW,Blaine TA,Macián F,Yang J,Lee FY

更新日期：2007-11-01 00:00:00

abstract：:"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

journal_title：Annals of the New York Academy of Sciences

authors： Blei F

更新日期：2008-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by autoimmune destruction of pancreatic beta cells. Genetic and environmental factors contribute in this disease. There is evidence that MHC class I chain-related gene (MIC-A) plays a role in the susceptibility to this and other autoimmune diseases...

journal_title：Annals of the New York Academy of Sciences

authors： Zake LN,Ghaderi M,Park YS,Babu S,Eisenbarth G,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical...

journal_title：Annals of the New York Academy of Sciences

authors： Talukdar FR,di Pietro M,Secrier M,Moehler M,Goepfert K,Lima SSC,Pinto LFR,Hendricks D,Parker MI,Herceg Z

更新日期：2018-12-01 00:00:00

abstract：:Cellulose degradation is a rare trait in bacteria. However, the truly cellulolytic bacteria are extremely efficient hydrolyzers of plant cell wall polysaccharides, especially those in thermophilic anaerobic ecosystems. Clostridium stercorarium, a thermophilic ubiquitous soil dweller, has a simple cellulose hydrolyzing...

journal_title：Annals of the New York Academy of Sciences

authors： Zverlov VV,Schwarz WH

更新日期：2008-03-01 00:00:00

abstract：:Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

journal_title：Annals of the New York Academy of Sciences

authors： Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

更新日期：2007-03-01 00:00:00

abstract：:A major challenge in systems biology is to evaluate the feasibility of a biological research project prior to its realization. Since experiments are animals-, cost- and time-consuming, approaches allowing researchers to discriminate alternative hypotheses with a minimal set of experiments are highly desirable. Given a...

journal_title：Annals of the New York Academy of Sciences

authors： Maiwald T,Kreutz C,Pfeifer AC,Bohl S,Klingmüller U,Timmer J

更新日期：2007-12-01 00:00:00

abstract：:Patients with renal impairment have an increased risk for cardiovascular disease, which may be the result of advanced glycation end products (AGEs). The aim of this study was to investigate the levels of AGE peptides in relation to kidney function and to study the relationship of AGE peptides with endothelial function...

journal_title：Annals of the New York Academy of Sciences

authors： Schalkwijk CG,Ter Wee PM,Stehouwer CD

更新日期：2005-06-01 00:00:00

abstract：:This study aimed to assess the value of different DXA and BIA models for predicting muscle volume in mid-thigh segments obtained by MRI. Three DXA models were used: in model A, muscle was taken to be equivalent to fat-free soft tissue; in model B the thigh segment was divided into its constituent tissues using fixed a...

journal_title：Annals of the New York Academy of Sciences

authors： Elia M,Fuller NJ,Hardingham CR,Graves M,Screaton N,Dixon AK,Ward LC

更新日期：2000-05-01 00:00:00

abstract：:The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction ...

journal_title：Annals of the New York Academy of Sciences

authors： Datta SK,Gavalchin J

更新日期：1986-01-01 00:00:00

abstract：:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relev...

journal_title：Annals of the New York Academy of Sciences

authors： Bocher V,Pineda-Torra I,Fruchart JC,Staels B

更新日期：2002-06-01 00:00:00