Abstract:
:Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell-to-cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the digestive mucosa is able to sample antigens and microorganisms through M cells of Peyer's patches' follicle-associated epithelium, in order to trigger the development of either tolerance or immune responses. At least in the gut, M-cell formation is immunoregulated. Close contact between immune cells and intestinal epithelium modifies the permeability of the epithelial barrier by inducing the conversion of enterocytes into M cells, offering at the same time an opportunistic way of invasion for pathogens. These lympho-epithelial interactions triggering M-cell formation have now been modeled in culture.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Hamzaoui N,Pringault Edoi
10.1111/j.1749-6632.1998.tb11111.xsubject
Has Abstractpub_date
1998-11-17 00:00:00pages
65-74eissn
0077-8923issn
1749-6632journal_volume
859pub_type
杂志文章,评审abstract::Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child-referenced items now make...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1425.001
更新日期:2008-01-01 00:00:00
abstract::Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2011.06414.x
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abstract::Phosphomannose isomerase (PMI), an enzyme not present in many plants, catalyzes the reversible interconversion of mannose 6-phosphate and fructose 6-phosphate. Plant cells lacking this enzyme are incapable of surviving on synthetic medium containing mannose. Thus PMI/mannose selection has utility in the identification...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
abstract::The article summarizes reports on the concurrence of Klinefelter's syndrome (KS) with inflammatory rheumatic diseases, rheumatoid arthritis (RA), juvenile idiopathic arthritis, psoriatic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, systemic sclerosis, mixed connective tissue disease, the anti...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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abstract::Ticks do not usually infest sympatric hosts species according to their availability in a given environment, and it has been suggested that habitat use by hosts is a major determinant of tick burdens. The knowledge of such infestation patterns and their relationship with host habitat use is important for the control of...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
abstract::The expression levels of GAP-43 and MAP-2, two proteins involved, respectively, in axonal and dendritic remodeling, in control adult (11 months), old (24 months), and vitamin E-deficient (11 months) rats were evaluated. mRNA levels were determined by means of a quantitative in situ hybridization procedure in subregion...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1976.tb41668.x
更新日期:1976-01-01 00:00:00
abstract::Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2006-08-01 00:00:00
abstract::Cold-restraint stress reduces gastric blood flow and produces acute gastric ulcers. We studied the role of Angiotensin II (Ang II) on gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated for 14 days with the AT(1) receptor antagonist cande...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
abstract::Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2014-05-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
abstract::Mouse models with targeted deletion of the genes encoding the enzyme 25-hydroxyvitamin D 1alpha-hydroxylase [1alpha(OH)ase], and the vitamin D receptor (VDR), have provided considerable insight into the regulation of mineral and skeletal physiology by 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Dietary manipulation induce...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2010-03-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2003-11-01 00:00:00
abstract::Thymosin β4 (Tβ4) is highly expressed in saliva of human newborns but not in adults. Here preliminary immunohistochemical analyses on different human tissues are reported. Immunoreactivity for Tβ4 in human salivary glands show high quantities of Tβ4 before birth, followed by downregulation of expression in adulthood. ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
abstract::According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heav...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1333.045
更新日期:2005-06-01 00:00:00
abstract::Megadose haploidentical transplants, mismatched at three HLA loci, engraft rapidly and durably without induction of graft-versus-host disease (GVHD). In vitro studies suggest that veto cells, contained in the population of hematopoietic progenitors, facilitate this favorable outcome. Cytotoxic T cells, not reactive ag...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract::This review has addressed the concern that the reduction of the risk of coronary heart disease and other cardiovascular disorders by means of reducing serum cholesterol levels might, at the same time, increase the risk of developing noncardiovascular conditions. This concern is justified because, at face value, prospe...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-17 00:00:00
abstract::SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) superfamily of genes. As Sox8 is widely expressed during development, and has male-specific expression at the critical period for sex determination, it was initially hypothesized that its inactivation would result in abnormal se...
journal_title:Annals of the New York Academy of Sciences
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abstract::The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic DNA sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains that bind specifically to the DNA sites (or response e...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1995-06-30 00:00:00
abstract::The Balb/c mice were infected with Coxiella burnetii and samples of blood and major organs from the infected mice were collected on days 1 to 14 after infection. The DNAs extracted from the samples were detected by a developed real-time quantitative PCR specific for C. burnetii and high loads of C. burnetii were found...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
abstract::Alexithymia has been associated with both posttraumatic stress disorder and neuroendocrine responses to stress. This study examined the relationship of alexithymia to salivary cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in a sample of police academy recruits exposed to a video stress challenge. Alexithymia sc...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
abstract::T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
abstract::Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system typically caused by duplications or missense mutations of the proteolipid protein (PLP) gene. Most investigators have found that peripheral nerve function and structure is normal in PMD patients. We have found that null mutat...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:
更新日期:1999-09-14 00:00:00
abstract::The airway disease termed asthma has been recognized for centuries but is now receiving increased attention because of chronicity, high incidence in the population and rising mortality rate. Asthma is now recognized as a disease of unknown etiology characterized by a hyperactive airway which can be demonstrated by res...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1991.tb37954.x
更新日期:1991-01-01 00:00:00
abstract::Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::Obesity is a phenotype resulting from a series of causative factors with a variable risk of complications. Etiologic diversity requires personalized prevention and treatment. Imaging procedures offer the potential to investigate the interplay between organs and pathways underlying energy intake and consumption in an i...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/nyas.12880
更新日期:2015-09-01 00:00:00
abstract::Humans can discriminate whether a change in the direction of gravito-inertial force (GIF) is caused by body tilt or by linear translation. This ability, attributed to vestibular sensory fusion, is often examined by asking subjects to adjust an indicator to match their subjective earth-fixed vertical (SV). We used two ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.03849.x
更新日期:2009-05-01 00:00:00
abstract::Legally, women, Native Americans, and African-Americans were defined by the American Constitution as inferior. The pragmatists gradually showed that all selves are equal. These ideas helped the minorities to attain nearly full legal status. But economic status is going in the other direction, toward inequality. It thr...
journal_title:Annals of the New York Academy of Sciences
pub_type: 历史文章,杂志文章
doi:10.1111/j.1749-6632.2011.06191.x
更新日期:2011-10-01 00:00:00