Modality-dependent indication of the subjective vertical during combined linear and rotational movements.

abstract：:Sixty years ago Hans Selye discovered that the neuroendocrine and immune systems interact during stress. The pathophysiological significance of neuroendocrine-immune interaction during injury has only been recognized recently. Today it is rapidly emerging that, in addition to defense against exogenous pathogenic agent...

journal_title：Annals of the New York Academy of Sciences

authors： Berczi I

更新日期：1998-06-30 00:00:00

abstract：:Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be impo...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman GB,Gibson GE

更新日期：1988-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of typ...

journal_title：Annals of the New York Academy of Sciences

authors： Lande R,Gilliet M

更新日期：2010-01-01 00:00:00

abstract：:Gonad-stimulating substance (GSS) is the first invertebrate gonadotropic neuropeptide hormone identified in a marine invertebrate, the starfish. Here, we show expression and distribution of GSS in various organs of the starfish Asterina pectinifera. Levels of GSS were high in the radial nerves and nerve ring. GSS was ...

journal_title：Annals of the New York Academy of Sciences

authors： Mita M,Ito C,Kubota E,Nagahama Y,Shibata Y

更新日期：2009-04-01 00:00:00

abstract：:We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JT

更新日期：1992-10-28 00:00:00

abstract：:Imatinib is a selective tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive leukemias and other malignancies. An important clinical observation is that imatinib can affect the function of normal nonmalignant cells resulting in myelosuppression in treated patients. This observation is s...

journal_title：Annals of the New York Academy of Sciences

authors： Balabanov S,Appel S,Kanz L,Brossart P,Brümmendorf TH

更新日期：2005-06-01 00:00:00

abstract：:Liquid diffusion experiments conducted on the MIR space station using the Canadian Space Agency QUELD II processing facility and the microgravity isolation mount (MIM) showed that g-jitter significantly increased the measured solute diffusion coefficients. In some experiments, milli-g forced vibration was superimposed...

journal_title：Annals of the New York Academy of Sciences

authors： Smith RW,Yang BJ,Huang WD

更新日期：2004-11-01 00:00:00

abstract：:The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...

journal_title：Annals of the New York Academy of Sciences

authors： LeJeune KE,Dravis BC,Yang F,Hetro AD,Doctor BP,Russell AJ

更新日期：1998-12-13 00:00:00

abstract：:Developing limb or differentiating neural and blood cells are traditional models used to study programmed cell death in mammals. The developing mouse dentition can also be an attractive model for studying apoptosis regulation. Apoptosis is most extant during early odontogenesis in mice. The embryonic tooth pattern is ...

journal_title：Annals of the New York Academy of Sciences

authors： Peterková R,Peterka M,Lesot H

更新日期：2003-12-01 00:00:00

abstract：:Over the last years, El Sistema--the Venezuelan project started in 1975 and now acknowledged worldwide as the most significant example of collective music education--has inspired a profusion of remarkable initiatives on all continents. From the original impulse by founder José Antonio Abreu, strong social principles o...

journal_title：Annals of the New York Academy of Sciences

authors： Majno M

更新日期：2012-04-01 00:00:00

abstract：:B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

journal_title：Annals of the New York Academy of Sciences

authors： Lemoine S,Morva A,Youinou P,Jamin C

更新日期：2009-09-01 00:00:00

abstract：:Expression analysis and epidemiologic studies have provided indirect evidence that proteinases and growth factors play a role in the development of atherosclerosis and complications such as aneurysm formation and plaque rupture. Studies using genetically altered mice have proven to be an elegant tool to study the caus...

journal_title：Annals of the New York Academy of Sciences

authors： Luttun A,Carmeliet P

更新日期：2001-12-01 00:00:00

abstract：:We investigated the role of thrombin in the pathogenesis in atherosclerosis and restenosis. First we examined the effect of thrombin on cultured human vascular smooth muscle cells (VSMC). We showed that thrombin acts as a mitogen on VSMC through thrombin receptor. The expression of thrombin receptor was increased in t...

journal_title：Annals of the New York Academy of Sciences

authors： Maruyama I,Shigeta K,Miyahara H,Nakajima T,Shin H,Ide S,Kitajima I

更新日期：1997-04-15 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune s...

journal_title：Annals of the New York Academy of Sciences

authors： Sutterwala FS,Haasken S,Cassel SL

更新日期：2014-06-01 00:00:00

abstract：:Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolite...

journal_title：Annals of the New York Academy of Sciences

authors： Mannella CA

更新日期：2008-12-01 00:00:00

abstract：:The physiological status of presynaptic receptors, regulating sympathetic neurotransmitter release, remains subject to debate. Nevertheless, pharmacological techniques have shown presynaptic alpha-adrenoceptors, mediating a negative feedback inhibition of neuronal noradrenaline (NA) release, and presynaptic beta-adren...

journal_title：Annals of the New York Academy of Sciences

authors： Borkowski KR

更新日期：1990-01-01 00:00:00

abstract：:Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cong Y,Liu C,Weaver CT,Elson CO

更新日期：2004-12-01 00:00:00

abstract：:Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

journal_title：Annals of the New York Academy of Sciences

authors： Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

更新日期：2003-06-01 00:00:00

abstract：:Signal hyperintensities on magnetic resonance imaging (MRI) are increased in the white matter (WMH) and deep gray matter in dementia and depression and may have similar pathologies. However, no previous study has examined WMH in subjects with major depression. We carried out in vitro MRI on brain tissue from elderly s...

journal_title：Annals of the New York Academy of Sciences

authors： Thomas AJ,Perry R,Barber R,Kalaria RN,O'Brien JT

更新日期：2002-11-01 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of ch...

journal_title：Annals of the New York Academy of Sciences

authors： Ginter E

更新日期：1975-09-30 00:00:00

abstract：:The beta cell fate following immune-mediated damage depends on an intricate pattern of dozens of genes up- or downregulated in parallel and/or sequentially. We are utilizing microarray analysis to clarify the pattern of gene expression in primary rat beta cells exposed to the proapoptotic cytokines, IL-1beta and/or IF...

journal_title：Annals of the New York Academy of Sciences

authors： Eizirik DL,Kutlu B,Rasschaert J,Darville M,Cardozo AK

更新日期：2003-11-01 00:00:00

abstract：:Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

journal_title：Annals of the New York Academy of Sciences

authors： Lambert EH,Lindstrom JM,Lennon VA

更新日期：1976-01-01 00:00:00

abstract：:Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

更新日期：2000-09-01 00:00:00

abstract：:The remarkable hemodynamic changes of normal pregnancy are briefly reviewed. In addition, new findings and current concepts related to the underlying hormonal and molecular mechanisms are presented. Finally, work that is in progress as well as future directions is briefly discussed. ...

journal_title：Annals of the New York Academy of Sciences

authors： Conrad KP,Jeyabalan A,Danielson LA,Kerchner LJ,Novak J

更新日期：2005-05-01 00:00:00

abstract：:Calcium ions are essential to proper neurotransmission. Impairment in cytosolic Ca(2+) concentration and Ca(2+) signaling disturbs neuronal activity, leading to pathological consequences. In cells, a high-affinity plasma membrane calcium pump (PMCA) keeps free Ca(2+) in the nanomolar range. Among four genes encoding t...

journal_title：Annals of the New York Academy of Sciences

authors： Zylinska L,Kowalska I,Kozaczuk A

更新日期：2008-12-01 00:00:00

abstract：:It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of agin...

journal_title：Annals of the New York Academy of Sciences

authors： Hodes RJ,Sierra F,Austad SN,Epel E,Neigh GN,Erlandson KM,Schafer MJ,LeBrasseur NK,Wiley C,Campisi J,Sehl ME,Scalia R,Eguchi S,Kasinath BS,Halter JB,Cohen HJ,Demark-Wahnefried W,Ahles TA,Barzilai N,Hurria A,Hunt PW

更新日期：2016-12-01 00:00:00

abstract：:Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis (SSc). SRC occurs during the first 4 years of disease evolution in more than 75% of the cases, almost exclusively in patients with diffuse SSc. Other risk factors, including preceding corticosteroid therapy, have been associated...

journal_title：Annals of the New York Academy of Sciences

authors： Teixeira L,Mahr A,Berezné A,Noël LH,Guillevin L,Mouthon L

更新日期：2007-06-01 00:00:00

abstract：:To test a hypothesis about how otoliths resolve roll-tilts from translations, we measured human ocular torsion position [ocular counterrolling (OCR)] to maintained linear acceleration stimuli. All subjects (n = 8) were tested in two conditions where the same magnitude of shear along an interaural axis was generated in...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Curthoys IS,Betts GA,Burgess AM,Halmagyi GM

更新日期：1999-05-28 00:00:00