Phosphomannose isomerase, a novel plant selection system: potential allergenicity assessment.

Abstract:

:Phosphomannose isomerase (PMI), an enzyme not present in many plants, catalyzes the reversible interconversion of mannose 6-phosphate and fructose 6-phosphate. Plant cells lacking this enzyme are incapable of surviving on synthetic medium containing mannose. Thus PMI/mannose selection has utility in the identification of transformed plant cells. As part of the safety assessment transgenic plants undergo before commercialization, PMI has been evaluated for its potential allergenicity. Purified PMI protein was readily digestible in a simulated gastric environment. PMI has no sequence homology to known allergens, does not contain multiple disulfide bonds, and has no N-glycosylation consensus sequences. No detectable changes in glycoprotein profiles were detected in PMI-transformed plants as compared to nontransgenic controls. These results indicate that PMI lacks many of the attributes associated with known oral allergens.

journal_name

Ann N Y Acad Sci

authors

Privalle LS

doi

10.1111/j.1749-6632.2002.tb04138.x

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

129-38

eissn

0077-8923

issn

1749-6632

journal_volume

964

pub_type

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