The origin of downbeat nystagmus: an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells.

abstract：:We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these...

journal_title：Annals of the New York Academy of Sciences

authors： Leak LV,Petricoin EF 3rd,Jones M,Paweletz CP,Ardekani AM,Fusaro VA,Ross S,Liotta LA

更新日期：2002-12-01 00:00:00

abstract：:The Balb/c mice were infected with Coxiella burnetii and samples of blood and major organs from the infected mice were collected on days 1 to 14 after infection. The DNAs extracted from the samples were detected by a developed real-time quantitative PCR specific for C. burnetii and high loads of C. burnetii were found...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang J,Wen B,Chen M,Zhang J,Niu D

更新日期：2005-12-01 00:00:00

abstract：:In this paper, we show that the same panel of three microsatellite markers is useful for the detection of alterations in the DNA of tumor cells and plasma from patients diagnosed with SCLC and NSCLC. In 31% of the SCLC patients, we detected a microsatellite alteration(s) or LOH in at least one locus. In the group of p...

journal_title：Annals of the New York Academy of Sciences

authors： Bruhn N,Beinert T,Oehm C,Jandrig B,Petersen I,Chen XQ,Possinger K,Fleischhacker M

更新日期：2000-04-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:The understanding and control of embryo implantation represents the major challenge for assisted reproductive technologies. Along with developments in basic research and efforts to optimize embryo quality, the improvement of noninvasive and reliable methods to assess uterine receptivity constitutes an important step t...

journal_title：Annals of the New York Academy of Sciences

authors： Fanchin R

更新日期：2001-09-01 00:00:00

abstract：:Insulin-like peptide 3 (INSL3) is present in hyperactive and neoplastic thyrocytes, but the functional role of this relaxin-like peptide hormone during carcinogenesis in the thyroid gland is currently unknown. We generated new cell models of stable transfectants of the human follicular thyroid carcinoma cell line FTC-...

journal_title：Annals of the New York Academy of Sciences

authors： Bialek J,Hombach-Klonisch S,Fiebig B,Weber E,Hoang-Vu C,Klonisch T

更新日期：2009-04-01 00:00:00

abstract：:Women are four to eight times more likely to be affected by fibromyalgia syndrome (FMS). A lack of cortisol, potentially due to an adrenocortical deficit is postulated in FMS. The cause of such adrenal insufficiency is unknown. It could be assumed that stress exposure during critical periods contributes to vulnerabili...

journal_title：Annals of the New York Academy of Sciences

authors： Klingmann PO,Kugler I,Steffke TS,Bellingrath S,Kudielka BM,Hellhammer DH

更新日期：2008-12-01 00:00:00

abstract：:Two chemical classes of flavonoids, the flavan-3-ols (catechins and proanthocyanidins) and the anthocyanins, are the natural antioxidants present at the highest concentration in red grape and wine. In the berry, the anthocyanins are localized in the skins, similarly to other highly bioactive phenolics of grape such as...

journal_title：Annals of the New York Academy of Sciences

authors： Mattivi F,Zulian C,Nicolini G,Valenti L

更新日期：2002-05-01 00:00:00

abstract：:Indirect and direct experimental evidence demonstrates that both the entry of extracellular calcium and the liberation of calcium from intracellular stores can contribute to an increase in free cytoplasmic calcium concentration in endothelial cells, which seems to be an essential step in the synthesis and/or release o...

journal_title：Annals of the New York Academy of Sciences

authors： Rubanyi GM,Vanhoutte PM

更新日期：1988-01-01 00:00:00

abstract：:Growth and pubertal disturbances are the commonest endocrinopathies in homozygous thalassemia, accounting for significant morbidity in 70-80% children and adolescents globally. This review focuses on the pathophysiology of the endocrinopathy from a historical perspective and altered natural history induced by better c...

journal_title：Annals of the New York Academy of Sciences

authors： Chatterjee R,Bajoria R

更新日期：2010-08-01 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:Violence against women has been a problem in human cultures for centuries. This is still the case both in developed and in developing countries, but it is in developing countries where the problem is aggravated as the result of cultural norms that are tolerant of men exerting power over women and girls as a commonly a...

journal_title：Annals of the New York Academy of Sciences

authors： Pick S,Contreras C,Barker-Aguilar A

更新日期：2006-11-01 00:00:00

abstract：:Between 4 and 13% of people with schizophrenia commit suicide and between 25 and 50% make a suicide attempt, a reflection of the devastating toll this syndrome takes on the quality of life, that is, the subjective and objective sense of well-being. Many risk factors for suicide in schizophrenia have been identified, t...

journal_title：Annals of the New York Academy of Sciences

authors： Meltzer HY

更新日期：2001-04-01 00:00:00

abstract：:Patient privacy is one of the major issues in the development of modern clinical information system networks. Such networks will have to demonstrate an appropriate concern for privacy as a precondition of operation. Regulatory effectiveness analysis is a novel technique for measuring compliance with a technological re...

journal_title：Annals of the New York Academy of Sciences

authors： Brannigan VM

更新日期：1992-12-17 00:00:00

abstract：:Recently, cell-free fetal DNA has been found in maternal plasma and serum. This discovery opens up a new field of investigation and provides an easily accessible source of fetal genetic material for prenatal diagnosis. Prenatal diagnostic applications of fetal DNA in maternal plasma include the investigation of sex-li...

journal_title：Annals of the New York Academy of Sciences

authors： Lo YM

更新日期：2000-04-01 00:00:00

abstract：:Our previous results demonstrate the gastroprotective but not ulcerogenic action of glucocorticoids released in response to ulcerogenic stress factors. The present study was undertaken to investigate the possible mechanisms underlying the gastroprotective action of glucocorticoids in rat stomachs. The effects of defic...

journal_title：Annals of the New York Academy of Sciences

authors： Filaretova LP,Podvigina TT,Bagaeva TR,Tanaka A,Takeuchi K

更新日期：2004-06-01 00:00:00

abstract：:The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

journal_title：Annals of the New York Academy of Sciences

authors： Farries MA

更新日期：2004-06-01 00:00:00

abstract：:Sixty years ago Hans Selye discovered that the neuroendocrine and immune systems interact during stress. The pathophysiological significance of neuroendocrine-immune interaction during injury has only been recognized recently. Today it is rapidly emerging that, in addition to defense against exogenous pathogenic agent...

journal_title：Annals of the New York Academy of Sciences

authors： Berczi I

更新日期：1998-06-30 00:00:00

abstract：:In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in beta cells and autonomic nerve terminals; the majority of these nerve terminals are parasympathetic. PACAP binds to three types of G protein-coupled receptors (GPCRs): VPAC1 receptors, VPAC2 receptors, and PAC1 recepto...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B

更新日期：2008-11-01 00:00:00

abstract：:Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

journal_title：Annals of the New York Academy of Sciences

authors： van der Vaart M,Pretorius PJ

更新日期：2008-08-01 00:00:00

abstract：:This paper will review our recent data relevant to the antioxidant effects of N-acetylserotonin (NAS), the immediate precursor of melatonin, the pineal gland indole. Mechanisms of the antioxidant effects of NAS might involve interaction with melatonin type 3 receptors and nonreceptor mechanisms such as stimulation of ...

journal_title：Annals of the New York Academy of Sciences

authors： Oxenkrug G

更新日期：2005-08-01 00:00:00

abstract：:The discovery of cell-free nucleic acids in plasma has opened up new possibilities for noninvasive clinical diagnosis. We demonstrate the presence of cell-free fetal RNA in maternal plasma, indicating that plasma fetal RNA might be used as a marker for noninvasive prenatal diagnosis. ...

journal_title：Annals of the New York Academy of Sciences

authors： Poon LL,Leung TN,Lau TK,Lo YM

更新日期：2001-09-01 00:00:00

abstract：:Physicians have used various forms of antipyretic therapy since antiquity to lower the temperature of febrile patients. Nevertheless, it has yet to be determined whether the benefits of antipyretic therapy outweigh its risks. It is not known, for example, if core temperatures encountered during the febrile state ever ...

journal_title：Annals of the New York Academy of Sciences

authors： Mackowiak PA,Plaisance KI

更新日期：1998-09-29 00:00:00

abstract：:BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

journal_title：Annals of the New York Academy of Sciences

authors： Bendinelli M,Toniolo A

更新日期：1976-01-01 00:00:00

abstract：:Insulin receptor isoform A (IR-A) is a fetal insulin receptor isoform that is overexpressed in cancer. We investigated whether insulin-like growth factor (IGF)-II may elicit a different gene expression response from insulin in cells expressing only IR-A and lacking IGF-I receptor (R-/IR-A cells). Cells were stimulated...

journal_title：Annals of the New York Academy of Sciences

authors： Pandini G,Conte E,Medico E,Sciacca L,Vigneri R,Belfiore A

更新日期：2004-12-01 00:00:00

abstract：:Hamster sperm DNA is packaged so tightly that it is the most highly condensed eukaryotic DNA known. Nevertheless, the sperm genome is also organized in a very specific fashion by two nuclear structures, the nuclear matrix and the nuclear annulus. The nuclear matrix organizes sperm DNA into loop domains approximately 4...

journal_title：Annals of the New York Academy of Sciences

authors： Farrington JE,Patel R,Ward WS

更新日期：1991-01-01 00:00:00

abstract：:In our study, we present a purely statistical observations-based model-free analysis that provides evidence about Granger causality (GC) from long-lived radiative forcings (LLRFs) to the climate trend (CT). This relies on having locally ordered breaks in the slopes of the trend functions of LLRF and the CT, with the b...

journal_title：Annals of the New York Academy of Sciences

authors： Estrada F,Perron P

更新日期：2019-01-01 00:00:00

abstract：:Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. To transfer this potential to the clinical laboratory, the development and the proper use of standards and calibrators are required to ensure comparability and r...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz A,Fernández-Repollet E

更新日期：1993-03-20 00:00:00

abstract：:Two types of mixed matrix membranes were developed by UOP in the late 1980s. The first type includes adsorbent polymers, such as silicalite-cellulose acetate (CA), NaX-CA, and AgX-CA mixed matrix membranes. The silicalite-CA has a CO(2)/H(2) selectivity of 5.15 +/- 2.2. In contrast, the CA membrane has a CO(2)/H(2) se...

journal_title：Annals of the New York Academy of Sciences

authors： Kulprathipanja S

更新日期：2003-03-01 00:00:00