The design of orally active iron chelators.

abstract：:The purpose of this study was to determine the seroprevalence against Bartonella henselae and Bartonella quintana among a risk group, patients with HIV infection, and to identify the epidemiological factors involved. Our data indicate that the prevalence of Bartonella infection among HIV-infected patients is much grea...

journal_title：Annals of the New York Academy of Sciences

authors： Pape M,Kollaras P,Mandraveli K,Tsona A,Metallidis S,Nikolaidis P,Alexiou-Daniel S

更新日期：2005-12-01 00:00:00

abstract：:Leukocyte trafficking from the blood stream to tissues is essential for continuous surveillance of foreign antigens. This dynamic process, designated as the leukocyte adhesion cascade, involves distinct steps. In leukocyte adhesion deficiency (LAD) I the firm adhesion of leukocyte to the endothelium is defective, due ...

journal_title：Annals of the New York Academy of Sciences

authors： Hanna S,Etzioni A

更新日期：2012-02-01 00:00:00

abstract：:The musical pitch of harmonic complex sounds, such as instrumental sounds, is perceived primarily by decoding either the fundamental pitch (keynote) or spectral aspects of the stimuli, for example, single harmonics. We divided 334 professional musicians, including symphony orchestra musicians, 75 amateur musicians, an...

journal_title：Annals of the New York Academy of Sciences

authors： Schneider P,Sluming V,Roberts N,Bleeck S,Rupp A

更新日期：2005-12-01 00:00:00

abstract：:Thirty percent of 51 obese adolescent girls seeking treatment for their obesity engaged in binge eating. Two psychometric measures, "disinhibition" and "happiness and satisfaction" predicted 63% of the variance in severity of binge eating. There was no difference in the history of dieting between obese subjects who bi...

journal_title：Annals of the New York Academy of Sciences

authors： Berkowitz R,Stunkard AJ,Stallings VA

更新日期：1993-10-29 00:00:00

abstract：:The rates and properties of new mutations affecting fitness have implications for a number of outstanding questions in evolutionary biology. Obtaining estimates of mutation rates and effects has historically been challenging, and little theory has been available for predicting the distribution of fitness effects (DFE)...

journal_title：Annals of the New York Academy of Sciences

authors： Bataillon T,Bailey SF

更新日期：2014-07-01 00:00:00

abstract：:The fate of alpha-hemoglobin chains and the cause of membrane protein defects in thalassemic erythrocytes have been studied in: (1) human beta-thalassemia syndromes, (2) mouse beta-thalassemia, and (3) normal human erythrocytes loaded with purified alpha-hemoglobin chains. The similarity and differences observed in th...

journal_title：Annals of the New York Academy of Sciences

authors： Rouyer-Fessard P,Scott MD,Leroy-Viard K,Garel MC,Bachir D,Galacteros F,Beuzard Y

更新日期：1990-01-01 00:00:00

abstract：:We recently isolated a novel bHLH/PAS protein, CLIF (cycle like factor), by yeast two-hybrid screening of human umbilical endothelial cell cDNA library. CLIF is preferentially expressed in endothelial and neuronal cells. Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK, the ke...

journal_title：Annals of the New York Academy of Sciences

authors： Maemura K,Layne MD,Watanabe M,Perrell MA,Nagai R,Lee ME

更新日期：2001-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease characterized by impaired T lymphocyte immune effector functions. We have identified a disorder of signal transduction in SLE T cells involving the cyclic AMP/protein kinase A (cAMP/PKA) pathway. Cyclic AMP-stimulated PKA-catalyzed protein phosphor...

journal_title：Annals of the New York Academy of Sciences

authors： Kammer GM

更新日期：2002-06-01 00:00:00

abstract：:Most measurement devices for bioimpedance spectroscopy are coupled to the measured object (tissue) via electrodes. At frequencies > 500 kHz, they suffer from artifacts due to stray capacitances between electrode leads as well as between the ground and object. The noninvasive measurement of the brain conductivity is ha...

journal_title：Annals of the New York Academy of Sciences

authors： Scharfetter H,Ninaus W,Puswald B,Petrova GI,Kovachev D,Hutten H

更新日期：1999-04-20 00:00:00

abstract：:B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

journal_title：Annals of the New York Academy of Sciences

authors： Lemoine S,Morva A,Youinou P,Jamin C

更新日期：2009-09-01 00:00:00

abstract：:Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

journal_title：Annals of the New York Academy of Sciences

authors： Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

更新日期：1995-07-12 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:Experimental and observational findings suggest that calcium intake may protect against colorectal neoplasia. To investigate this hypothesis, we conducted a randomized, double-blind trial of colorectal adenoma recurrence. Nine hundred thirty patients with a recent history of colorectal adenomas were randomly given cal...

journal_title：Annals of the New York Academy of Sciences

authors： Baron JA,Beach M,Mandel JS,van Stolk RU,Haile RW,Sandler RS,Rothstein R,Summers RW,Snover DC,Beck GJ,Frankl H,Pearson L,Bond JH,Greenberg ER

更新日期：1999-01-01 00:00:00

abstract：:Evidence has been presented that lipoxygenase products of arachidonic acid metabolism released during the early stages of allergic reactions play an important role in the subsequent development of late bronchial responses. Moreover, because of this, the activity of the lipoxygenase pathway and sensitivity to the produ...

journal_title：Annals of the New York Academy of Sciences

authors： Abraham WM

更新日期：1988-01-01 00:00:00

abstract：:Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul S,Padgett RC,Heistad DD

更新日期：1994-04-18 00:00:00

abstract：:Bone marrow cells of various animal species and the human produce a group of bioregulatory peptides called myelopeptides (MPs). A highly purified myelopeptide (MP) fraction and some individual molecules have been isolated from the supernatant of the porcine bone marrow cell culture by successive gel chromatography and...

journal_title：Annals of the New York Academy of Sciences

authors： Petrov RV

更新日期：1993-06-23 00:00:00

abstract：:BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

journal_title：Annals of the New York Academy of Sciences

authors： Bendinelli M,Toniolo A

更新日期：1976-01-01 00:00:00

abstract：:To live beyond the octogenarian years, population and molecular genetic studies of centenarian sibships indicate that genetic factors play an increasingly important role as the limit of life span is approached. These factors are likely to influence basic mechanisms of aging that in turn broadly influence susceptibilit...

journal_title：Annals of the New York Academy of Sciences

authors： Perls T

更新日期：2002-04-01 00:00:00

abstract：:Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut perme...

journal_title：Annals of the New York Academy of Sciences

authors： Sung MK,Yeon JY,Park SY,Park JH,Choi MS

更新日期：2011-07-01 00:00:00

abstract：:Lipopolysaccharide (LPS), an endotoxin that elicits the production of several cytokines, induces cardiovascular changes characterized by increased perfusion of immune organs and compensatory sympathetic vasoconstriction in other tissues. We therefore hypothesized that to adapt to altered blood flow distribution follow...

journal_title：Annals of the New York Academy of Sciences

authors： Rogausch H,Vo NT,Del Rey A,Besedovsky HO

更新日期：2000-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by autoimmune destruction of pancreatic beta cells. Genetic and environmental factors contribute in this disease. There is evidence that MHC class I chain-related gene (MIC-A) plays a role in the susceptibility to this and other autoimmune diseases...

journal_title：Annals of the New York Academy of Sciences

authors： Zake LN,Ghaderi M,Park YS,Babu S,Eisenbarth G,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:Plaques with lipid macrophages and macrophages containing undigested myelin fragments from five multiple sclerosis patients were studied by light microscopy of epoxy-embedded tissue (five cases) and electron microscopy (one case). Cell counts determined electron microscopically revealed that oligodendrocytes were redu...

journal_title：Annals of the New York Academy of Sciences

authors： Prineas JW,Kwon EE,Cho ES,Sharer LR

更新日期：1984-01-01 00:00:00

abstract：:The rostral nucleus of the solitary tract (rNST) plays a key role in modulating, organizing and distributing the sensory information arriving at the central nervous system from gustatory receptors. However, except for some anatomical studies of rNST synapses, the neural circuits responsible for this first stage in syn...

journal_title：Annals of the New York Academy of Sciences

authors： Bradley RM,Grabauskas G

更新日期：1998-11-30 00:00:00

abstract：:Information from the vestibular nuclei ascending through the brainstem to the oculomotor and trochlear nuclei (NIII, NIV), the interstitial nucleus of Cajal (INC), the pretectum, or thalamus, is thought to be distributed in at least five different pathways. They include the medial longitudinal fasciculus (MLF), the as...

journal_title：Annals of the New York Academy of Sciences

authors： Zwergal A,Strupp M,Brandt T,Büttner-Ennever JA

更新日期：2009-05-01 00:00:00

abstract：:Mouse pheochromocytoma cells (MPCs) provide an excellent model system for investigating the effects of hypoxia on catecholamine enzyme genes and on transcription factors mediating stress responses. RT-PCR detects rapid, transient increases in PNMT mRNA in hypoxic MPC 712 cells. Additionally, elevation of mRNAs encodin...

journal_title：Annals of the New York Academy of Sciences

authors： Evinger MJ,Cikos S,Nwafor-Anene V,Powers JF,Tischler AS

更新日期：2002-10-01 00:00:00

abstract：:Until now, neoadjuvant therapy plus surgical resection of the primary tumor and potential metastatic lymph nodes (LNs) has been the current optimal treatment for locally advanced thoracic esophageal cancer (EC). LN metastasis is one of the most negative prognostic factors for thoracic esophageal squamous cell carcinom...

journal_title：Annals of the New York Academy of Sciences

authors： Wang Z,Mao Y,Gao S,Li Y,Tan L,Daiko H,Liu S,Chen C,Koyanagi K,He J

更新日期：2020-12-01 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:The concentration of materials and energy within cities is an inevitable consequence of dense populations and their per capita requirements for food, fiber, and fuel. As the world population becomes increasingly urban over the coming decades, urban areas will dramatically affect the distribution of nutrients across th...

journal_title：Annals of the New York Academy of Sciences

authors： Bernhardt ES,Band LE,Walsh CJ,Berke PE

更新日期：2008-01-01 00:00:00

abstract：:Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic ph...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HJ,Lee KW,Lee HJ

更新日期：2007-01-01 00:00:00

abstract：:We examined the role of I1-imidazoline (I1-IR) receptors in control of airway function, by testing the effects of systemic administration of the I1-IR agonist moxonidine on reflex responses of tracheal smooth muscle (TSM) tone to either lung deflation or mechanical stimulation of intrapulmonary rapidly adapting recept...

journal_title：Annals of the New York Academy of Sciences

authors： Haxhiu MA,Dreshaj IA,McFadden CB,Erokwu BO,Ernsberger P

更新日期：1999-06-21 00:00:00