The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.

abstract：:Hepatitis B virus (HBV) of man has several characteristics that distinguish it from viruses of other groups. These include its ultrastructure, viral DNA size and structure, a virion DNA polymerase which repairs a single-stranded region in the viral DNA, liver tropism, character of persistent infection, and association...

journal_title：Annals of the New York Academy of Sciences

authors： Robinson WS

更新日期：1980-01-01 00:00:00

abstract：:Tick burdens cause direct damage to hosts and transmit several disease agents, the majority of which are secreted into feeding lesions through tick salivary glands. Reduced incidence of naturally transmitted tick-borne diseases was recently observed among cattle immunized with tick salivary gland extracts (TSGE). The ...

journal_title：Annals of the New York Academy of Sciences

authors： Jittapalapong S,Phichitrasilp T,Chanphao H,Rerkamnuychoke W,Stich RW

更新日期：2008-12-01 00:00:00

abstract：:The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulat...

journal_title：Annals of the New York Academy of Sciences

authors： Moutsatsou P,Sekeris CE

更新日期：1997-06-17 00:00:00

abstract：:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked t...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

更新日期：2012-07-01 00:00:00

abstract：:Blood-borne beta-amyloids (A beta s) could affect brain function by (1) crossing the BBB to directly interact with brain tissues or (2) altering BBB function by interacting with the brain capillaries that make up the BBB. Several radioactively labeled A beta s have been examined for such interactions. Blood-borne A be...

journal_title：Annals of the New York Academy of Sciences

authors： Banks WA,Kastin AJ,Maness LM,Banks MF,Shayo M,McLay RN

更新日期：1997-09-26 00:00:00

abstract：:Our studies of Ca2+ release have shown that three classes of compounds--quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges--all have potential in probing the mech...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Shoshan V,Wood DS

更新日期：1982-01-01 00:00:00

abstract：:Rheumatoid arthritis is the most common of a number of diseases in which inflammation and tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and this has prompted major research efforts, both in academia and industry, to understand more about the pathogenesis, and hence provide the r...

journal_title：Annals of the New York Academy of Sciences

authors： Feldmann M,Brennan FM,Elliott MJ,Williams RO,Maini RN

更新日期：1995-09-07 00:00:00

abstract：:A sensitive, accurate, and simple method, called shifted termination assay (STA), was developed for detection of genetic mutations. The STA technology can be used to detect genetic mutations in polymerase chain reaction (PCR)-amplified samples of tissue, and plasma and serum that include circulating DNA containing poi...

journal_title：Annals of the New York Academy of Sciences

authors： Shackelford W,Deng S,Murayama K,Wang J

更新日期：2004-06-01 00:00:00

abstract：:Methamphetamine (METH) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (DA) and its metabolites, high-affinity DA uptake sites, and the activity of tyrosine hydroxylase. The present study was undertaken to investigate whether the relatively selective, neuronal nitric ...

journal_title：Annals of the New York Academy of Sciences

authors： Ali SF,Itzhak Y

更新日期：1998-05-30 00:00:00

abstract：:Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses af...

journal_title：Annals of the New York Academy of Sciences

authors： Cantley LC,Whitman M,Chahwala S,Fleischman L,Kaplan DR,Schaffhausen BS,Roberts TM

更新日期：1986-01-01 00:00:00

abstract：:Hereditary episodic ataxia (EA) syndromes are rare monogenic disorders that are phenotypically and genetically heterogeneous. The number of identified EA phenotypes is expanding. So far, mutations have been identified in four genes, all coding for membrane proteins including ion channels and transporters. The study of...

journal_title：Annals of the New York Academy of Sciences

authors： Jen JC

更新日期：2008-10-01 00:00:00

abstract：:The importance of prognostic factors in predicting outcome in pediatric oncology is largely recognized, and most current protocols tailor treatment based on risk stratification. Further refinements of classical staging systems are ongoing, and the future of pediatric oncology is in the development of strategies based ...

journal_title：Annals of the New York Academy of Sciences

authors： Yanagisawa T,Bartels U,Bouffet E

更新日期：2008-09-01 00:00:00

abstract：:Factors that regulate various pathways of Maillard reaction leading to aroma, color, or carcinogen generation have not been identified, due to the difficulties associated with analyzing complex reaction mixtures. In particular, the role played by oxidation in directing aromagenic, chromogenic, or carcinogenic pathways...

journal_title：Annals of the New York Academy of Sciences

authors： Yaylayan VA,Haffenden L,Chu FL,Wnorowski A

更新日期：2005-06-01 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic ph...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HJ,Lee KW,Lee HJ

更新日期：2007-01-01 00:00:00

abstract：:Image processing in fluid mechanics has become an important quantitative tool for flow analysis. The feasibility of simultaneous measurements of instantaneous velocity and temperature fields, as well as for tracking interfaces, creates a functional tool to describe thermally driven flows accompanied by phase change. T...

journal_title：Annals of the New York Academy of Sciences

authors： Kowalewski TA

更新日期：2002-10-01 00:00:00

abstract：:In this paper we first present methods and preliminary results of pilot surveys of "serious" mental retardation (IQ less than or equal to 55); the surveys included screening and diagnostic components and were carried out in the less-developed world. Next we discuss two problems raised by these surveys: one is the diag...

journal_title：Annals of the New York Academy of Sciences

authors： Stein Z,Durkin M,Belmont L

更新日期：1986-01-01 00:00:00

abstract：:Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune s...

journal_title：Annals of the New York Academy of Sciences

authors： Sutterwala FS,Haasken S,Cassel SL

更新日期：2014-06-01 00:00:00

abstract：:While dopamine (DA) receptors mediate acute effects of amphetamine and cocaine, chronic drug administration produces many glutamate-dependent adaptations, including LTP in reward-related neuronal circuits. An important question presents itself: How do DA receptors influence glutamate-dependent synaptic plasticity? Alt...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf ME,Mangiavacchi S,Sun X

更新日期：2003-11-01 00:00:00

abstract：:The involvement of the c-Myc transcription factor in neoplastic transformation is well documented. However, which of its numerous target genes are crucial for tumorigenesis remains a frequently contested issue. We have recently established a non-transgenic murine model for B-cell lymphoma based on neoplastic conversio...

journal_title：Annals of the New York Academy of Sciences

authors： Yu D,Cozma D,Park A,Thomas-Tikhonenko A

更新日期：2005-11-01 00:00:00

abstract：:Leukocyte trafficking from the blood stream to tissues is essential for continuous surveillance of foreign antigens. This dynamic process, designated as the leukocyte adhesion cascade, involves distinct steps. In leukocyte adhesion deficiency (LAD) I the firm adhesion of leukocyte to the endothelium is defective, due ...

journal_title：Annals of the New York Academy of Sciences

authors： Hanna S,Etzioni A

更新日期：2012-02-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:In preindustrial settings, biological, economic, and social mechanisms caused fertility to respond to feedback signals from population size variation in such a way as to steer populations toward equilibrium levels. It is unlikely that the relevant signal was population density; more plausibly the signal was economic w...

journal_title：Annals of the New York Academy of Sciences

authors： Lee R

更新日期：1994-02-18 00:00:00

abstract：:Child maltreatment (CM) not only has detrimental and lifelong psychological consequences, but also can lead to lasting alterations in core physiological systems--a biological memory of CM. Furthermore, some of these alterations might even be transmitted to the next generation. This article describes current knowledge ...

journal_title：Annals of the New York Academy of Sciences

authors： Schury K,Kolassa IT

更新日期：2012-07-01 00:00:00

abstract：:Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding the physiological nature of the suppressive actions, and the hypothesis that they prevent stress-activated defense mechanisms from overshooting and da...

journal_title：Annals of the New York Academy of Sciences

authors： Munck A,Náray-Fejes-Tóth A

更新日期：1994-11-30 00:00:00

abstract：:Proopiomelanocortin (POMC) and proenkephalin (PE) are synthesized at the endoplasmic reticulum and transported to the trans-Golgi network (TGN) where they are sorted and packaged into dense-core granules of the regulated secretory pathway (RSP). The mechanism of sorting POMC and PE to the RSP in neuroendocrine cells w...

journal_title：Annals of the New York Academy of Sciences

authors： Loh YP,Maldonado A,Zhang C,Tam WH,Cawley N

更新日期：2002-10-01 00:00:00

abstract：:"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

journal_title：Annals of the New York Academy of Sciences

authors： Blei F

更新日期：2008-01-01 00:00:00

abstract：:The search for molecules on the surface of mammalian sperm that are responsible for the binding of sperm to the zona pellucida has led to the identification of a number of different surface proteins. Different experimental approaches have been used to identify these proteins and the strength of the evidence for their ...

journal_title：Annals of the New York Academy of Sciences

authors： Myles DG,Primakoff P

更新日期：1991-01-01 00:00:00

abstract：:This chapter considers violence prevention programs in light of aggression and violence directed toward girls and women. More specifically, current violence prevention programs, directed toward young children and/or their caregivers, are discussed with a special consideration for the Adults and Children Together (ACT)...

journal_title：Annals of the New York Academy of Sciences

authors： Guttman M,Mowder B,Yasik A

更新日期：2006-11-01 00:00:00

abstract：:Tularemia is a disease caused by several subspecies of Francisella tularensis, although the severity of the disease varies greatly from subspecies to subspecies. Currently, there are four recognized subspecies (tularensis, holarctica, mediasiatica, and novicida), in addition to a second Francisella species, F. philomi...

journal_title：Annals of the New York Academy of Sciences

authors： Keim P,Johansson A,Wagner DM

更新日期：2007-06-01 00:00:00