Abstract:
:The purpose of the present experiment was to determine if there is a factor in serum of patients with myasthenia gravis (MG) that interferes with binding of (125I)-alpha-bungarotoxin to acetylcholine receptors of normal mouse diaphragm. Diaphragms were incubated aerobically for 1 hour in either Krebs-Henseleit solution, MG serum, or control serum, and then (125I)-alpha bungarotoxin was added for 2 further hours at a concentration of 1 mug/ml. After 12 rinses in Krebs-Henseleit solution for another hour, radioactivity was counted. Binding after exposure to MG serum was compared to that obtained after exposure to Krebs-Henseleit solution or control serum. Sixteen sera from 14 controls, 18 sera from 15 patients with moderate generalized MG, and seven sera from seven patients on alternate-day prednisone therapy (six with severe generalized MG, one with myasthenic syndrome) were tested by this method. No significant difference in alpha-bungarotoxin binding was observed between normal mouse diaphragm incubated in MG sera and those incubated in control sera.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Keesey J,Shaikh I,Wolfgram F,Chao LPdoi
10.1111/j.1749-6632.1976.tb47690.xsubject
Has Abstractpub_date
1976-01-01 00:00:00pages
244-53eissn
0077-8923issn
1749-6632journal_volume
274pub_type
杂志文章,评审abstract::This chapter considers violence prevention programs in light of aggression and violence directed toward girls and women. More specifically, current violence prevention programs, directed toward young children and/or their caregivers, are discussed with a special consideration for the Adults and Children Together (ACT)...
journal_title:Annals of the New York Academy of Sciences
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abstract::Thromboembolic and infectious events were found to be major complications of long-term total artificial heart implantation in two patients. Similar complications have been reported in other patients, as well as in animal studies. The thromboembolic events and the infectious complications appear to be interrelated. On ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
abstract::Leptin is the product of the ob gene located in humans on chromosome 7q31.3. It is a 16-kDa protein named after the Greek "leptos," meaning lean, to indicate the function that this adipocyte-secreted protein was thought to have. Since its discovery, in fact, most of the research focused on the role of leptin in body-w...
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1998-12-15 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2006-07-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-17 00:00:00
abstract::The paper describes a comprehensive and objective evaluation of 2358 persons arrested in Philadelphia for driving while intoxicated. It was demonstrated that 63.8% of this population was involved with alcohol to an extent that a diagnosis of alcoholism was evident, and it is suggested that these persons are in need of...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1976.tb52938.x
更新日期:1976-01-01 00:00:00
abstract::Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
abstract::Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A. Such azole resistance is either primary or secondary (in the ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:1997-12-31 00:00:00
abstract::The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2004-06-01 00:00:00
abstract::The benefits of estrogen replacement therapy in postmenopausal women include increased quality of life, relief from specific symptoms, and the prevention of osteoporosis, genitourinary atrophy, and cardiovascular diseases. Despite these advantages, this therapy has been reported to be associated with an increased freq...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
abstract::Corn flour and maize meal fortification can benefit the consumer when the added nutrient contents are in amounts appropriate to address nutrient gaps. Legislative instruments (standards and regulations) are needed to provide guidance to the producers and food control authorities. We reviewed a number of national stand...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2014-04-01 00:00:00
abstract::A male factor is implicated in about 50% of couples treated with advanced assisted reproductive techniques (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]). An important function of spermatozoa is to deliver the paternal genome to the oocyte. However, neither the routine testing of male fertil...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2008-04-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
abstract::Athletic women are at risk for developing ovulatory dysfunction, which presents variably as menstrual irregularity or absence. Initially characterized as an isolated disruption of hypothalamic gonadotropin-releasing hormone (GnRH) release, athletic amenorrhea, a form of hypogonadotropic hypogonadism, is invariably acc...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2010-09-01 00:00:00
abstract::The membrane domain of the Na(+)/Ca(2+) exchanger (NCX) contains two conserved internal repeat sequences, designated the alpha-1 and alpha-2 repeats. We have studied the topological disposition of residues in the alpha repeats and a neighboring region by substituted cysteine accessibility scanning as well as the funct...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2002.tb04710.x
更新日期:2002-11-01 00:00:00
abstract::The current research has demonstrated that MPP+ can induce lipid peroxidation in the nigrostriatal system of rat in vivo. Antioxidant agent U-78517F and .OH scavenger DMSO may protect against MPP+ toxicity through the inhibition of .OH radical-mediated oxidative injury in the substantia nigra. These findings indicate ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1994-11-17 00:00:00
abstract::In this paper a novel algorithm is proposed for space trajectory design that combines a systematic and a heuristic method for global optimization. For the systematic part of the algorithm a branching technique is used, whereas a particular implementation of evolution programming forms the core of the heuristic part. T...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00