Abstract:
:Leptin is the product of the ob gene located in humans on chromosome 7q31.3. It is a 16-kDa protein named after the Greek "leptos," meaning lean, to indicate the function that this adipocyte-secreted protein was thought to have. Since its discovery, in fact, most of the research focused on the role of leptin in body-weight regulation, aiming to elucidate the pathophysiology of human obesity. However, more and more data show that leptin is not only important in the regulation of food intake and energy balance, but it also functions as a neuroendocrine hormone. It is involved in glucose metabolism, as well as in normal sexual maturation and reproduction, and interacts with the hypothalamic-pituitary-adrenal (HPA) and the growth hormone (GH) axes.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Ghizzoni L,Mastorakos Gdoi
10.1196/annals.1290.007subject
Has Abstractpub_date
2003-11-01 00:00:00pages
56-63eissn
0077-8923issn
1749-6632journal_volume
997pub_type
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