Searching for stem cell regulatory molecules. Some general thoughts and possible approaches.

Abstract:

:Hematopoietic development in the mammal can be represented as a numerically expanding hierarchy of cell populations that are progressively restricted in their self-renewal and differentiation abilities. Classical functional studies have now been extended to provide exact physical descriptions of various stages in the hematopoietic hierarchy. In particular, much information is available that defines the properties of the most primitive stem cell compartment. In addition, a number of in vitro culture systems suggest the possibility of maintaining and expanding these cells in a defined context. In all developmental systems, unique profiles of expressed genes define distinct differentiation stages. Within these profiles are gene products that play crucial roles in the regulation of cell-fate decisions. Recent progress in hematopoietic biology provides the framework within which to define molecular phenotypes for hematopoietic stem cells and their immediate clonal progeny. Identifying novel gene products expressed predominantly in uncommitted stem cells together with functional loss and gain-of-function approaches should begin to unravel the molecular mechanisms that govern biological phenomena such as self-renewal, commitment, and proliferation in the hematopoietic system.

journal_name

Ann N Y Acad Sci

authors

Lemischka I

doi

10.1111/j.1749-6632.1999.tb08472.x

subject

Has Abstract

pub_date

1999-04-30 00:00:00

pages

274-87; discussion 287-8

eissn

0077-8923

issn

1749-6632

journal_volume

872

pub_type

杂志文章,评审
  • The estimation of probable maximum precipitation: the case of Catalonia.

    abstract::A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1446.003

    authors: Casas MC,Rodríguez R,Nieto R,Redaño A

    更新日期:2008-12-01 00:00:00

  • Some effects of exposure of the Japanese quail embryo to 2.45-GHz microwave radiation.

    abstract::Exposure of quail eggs 4 hr per day during the first 5 incubation days at 2450 MHz and in an exposure field of 30 mW/cm-2 and at an absorbed power of 14 mW/g does not cause any great change in body weight, observed gross malformations, rbc, wbc, hematocrit, hemoglobin, or differential wbc percentages. If small differe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1975.tb36012.x

    authors: McRee DI,Hamrick PE,Zinkl J,Thaxton P,Parkhurst CR

    更新日期:1975-02-28 00:00:00

  • Difference in enzymatic properties between "staphylothrombin" and free alpha-thrombin.

    abstract::Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb34565.x

    authors: Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

    更新日期:1986-01-01 00:00:00

  • Synergistic effects of antiviral agents and humoral antibodies in experimental Herpesvirus hominis encephalitis.

    abstract::Experimental Herpesvirus hominis encephalitis in 3-week-old Swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-A), phosphonacetic acid (PAA), and humoral antibodies to H. hominis (HIG). Administration of ara-A, PAA, or HIG during the early phase of infection reduced the mortality rat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1977.tb21967.x

    authors: Cho CT,Feng KK

    更新日期:1977-03-04 00:00:00

  • Challenging the neurobiological link between number sense and symbolic numerical abilities.

    abstract::A significant body of research links individual differences in symbolic numerical abilities, such as arithmetic, to number sense, the neurobiological system used to approximate and manipulate quantities without language or symbols. However, recent findings from cognitive neuroscience challenge this influential theory....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14225

    authors: Wilkey ED,Ansari D

    更新日期:2020-03-01 00:00:00

  • Cellular and molecular neuropathology of the parahippocampal region in schizophrenia.

    abstract::The entorhinal cortex, subiculum, and hippocampus have been regions of great interest in both clinical and neuropathological investigations of schizophrenia. Postmortem studies have identified numerous abnormalities, although many remain controversial or unconfirmed. Among the cellular and molecular neuropathological ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06732.x

    authors: Arnold SE

    更新日期:2000-06-01 00:00:00

  • Medial vestibular nucleus lesions in Wallenberg's syndrome cause decreased activity of the contralateral vestibular cortex.

    abstract::Three patients with the clinical diagnosis of Wallenberg's syndrome caused by acute unilateral ischemic infarctions, which included the vestibular nucleus in the medullary brain stem and afferent vestibular pathways, were examined by positron emission tomography (PET) during caloric vestibular stimulation. They all ha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.035

    authors: Dieterich M,Bense S,Stephan T,Brandt T,Schwaiger M,Bartenstein P

    更新日期:2005-04-01 00:00:00

  • Influence of interleukin-1 receptor antagonist on [3H]serotonin and histamine release by rat basophilic leukemia-2H3 cells.

    abstract::Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb46250.x

    authors: Conti P,Barbacane RC,Trakatellis M,Placido FC,Cataldo I,Reale M

    更新日期:1997-12-15 00:00:00

  • Song-induced gene expression: a window on song auditory processing and perception.

    abstract::We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1298.021

    authors: Mello CV,Velho TA,Pinaud R

    更新日期:2004-06-01 00:00:00

  • Generation of reactive oxygen and nitrogen species in contracting skeletal muscle: potential impact on aging.

    abstract::Since the early 1980s biologists have recognized that skeletal muscle generates free radicals. Of particular interest are two closely related redox cascades--reactive oxygen species (ROS) and nitric oxide (NO) derivatives. The ROS cascade is initiated by superoxide anion radicals derived from the mitochondrial electro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb02087.x

    authors: Reid MB,Durham WJ

    更新日期:2002-04-01 00:00:00

  • PET/CT imaging in infectious conditions.

    abstract::New aggressive pathogens are responsible for the increasing incidence and difficult management of infections. Modern epidemics such as diabetes are frequently complicated by severe infections with subsequent high morbidity. Diagnosis (essentially early detection of infection) and also management decision making pose c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06026.x

    authors: Israel O,Keidar Z

    更新日期:2011-06-01 00:00:00

  • Is beat induction innate or learned? Probing emergent meter perception in adults and newborns using event-related brain potentials.

    abstract::Meter is considered an important structuring mechanism in the perception and experience of rhythm in music. Combining behavioral and electrophysiological measures, in the present study we investigate whether meter is more likely a learned phenomenon, possibly a result of musical expertise, or whether sensitivity to me...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04761.x

    authors: Honing H,Ladinig O,Háden GP,Winkler I

    更新日期:2009-07-01 00:00:00

  • The immunopathology of acquired myasthenia gravis.

    abstract::Specific probes (alpha-bungarotoxin for acetylcholine receptor (AChR), staphylococcal protein A for IgG, monospecific antibodies against C3 and C9) labelled with peroxidase were applied to study of the ultrastructure of the MG end plate. In each case of MG there was postsynaptic AChR deficiency, usually greatest at en...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1981.tb33730.x

    authors: Engel AG,Sahashi K,Fumagalli G

    更新日期:1981-01-01 00:00:00

  • Symmetry of the activation of cyclin-dependent kinases in mitogen and growth factor-stimulated T lymphocytes.

    abstract::The entry of resting T cells into the G1 phase of the cell cycle after stimulation by mitogens is controlled by a series of biochemical events that are independent of growth factors. These events follow the initial signals stimulated through the engagement of the T-cell receptor and include activation of the cyclin-de...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb26657.x

    authors: Modiano JF,Domenico J,Szepesi A,Terada N,Lucas JJ,Gelfand EW

    更新日期:1995-09-07 00:00:00

  • Translational research of ghrelin.

    abstract::Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05509.x

    authors: Ueno H,Shiiya T,Nakazato M

    更新日期:2010-07-01 00:00:00

  • A survey of the hormonal factors that control calcium metabolism.

    abstract::(1) Vitamin D is the precursor of an extremely potent calcium regulating hormone, 1,25(OH)2D3, which is secreted by the kidney. (2) The secretion of 1,25(OH)2D3 by the kidney is influenced by the calcium and phosphorus content of the diet, parathyroid hormone, and 1,25(OH)2D3 itself. (3)Prolactin and growth hormone ar...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1978.tb41961.x

    authors: MacIntyre I,Colston KW,Szelke M,Spanos E

    更新日期:1978-04-28 00:00:00

  • Studies on heterocycle-based pure estrogen antagonists.

    abstract::2-Phenylindoles and isosteric structures such as benzo[b]furans and benzo[b]thiophenes were used as estrogen receptor binding moiety for the syntheses of new nonsteroidal antiestrogens. The antiestrogenic potency was considerably enhanced following the introduction of polar functional groups into the side chain in pos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1995.tb31378.x

    authors: Von Angerer E,Biberger C,Leichtl S

    更新日期:1995-06-12 00:00:00

  • N-acetylcysteine attenuates arsenite-induced oxidative injury in dorsal root ganglion explants.

    abstract::Chronic exposure to arsenic causes health problems, including peripheral neuropathy. Oxidative stress is one of the mechanisms underlying arsenic-induced neurotoxicity. For this report, we studied the protective effect of N-acetylcysteine (NAC) on arsenic-induced oxidative injury in dorsal root ganglion (DRG) explants...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1403.020

    authors: Chao PL,Fan SF,Chou YH,Lin AM

    更新日期:2007-12-01 00:00:00

  • Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.

    abstract::This study investigates the effects of agmatine on naloxone-precipitated withdrawal syndrome in morphine-dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1304.016

    authors: Aricioglu F,Ercil E,Dulger G

    更新日期:2003-12-01 00:00:00

  • Assessment and treatment of pain in thalassemia.

    abstract::Pain is a subjective symptom whose prevalence can be grossly underestimated. The high proportion of adults with thalassemia who experience chronic pain is evident from recent surveys. However, pain has not received enough attention in the overall management of thalassemia. The association of pain with the type and tre...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13061

    authors: Lal A

    更新日期:2016-03-01 00:00:00

  • Plasma levels of AGE peptides in type 1 diabetic patients are associated with serum creatinine and not with albumin excretion rate: possible role of AGE peptide-associated endothelial dysfunction.

    abstract::Patients with renal impairment have an increased risk for cardiovascular disease, which may be the result of advanced glycation end products (AGEs). The aim of this study was to investigate the levels of AGE peptides in relation to kidney function and to study the relationship of AGE peptides with endothelial function...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1333.075

    authors: Schalkwijk CG,Ter Wee PM,Stehouwer CD

    更新日期:2005-06-01 00:00:00

  • Expression of somatostatin receptors in normal, inflamed, and neoplastic human gastrointestinal tissues.

    abstract::The multiple actions of somatostatin are mediated by specific membrane-bound receptors present in all somatostatin target tissues, such as brain, pituitary, pancreas, gastrointestinal tract, and kidney. For instance, in the human gastrointestinal tract, three different types of tissue compartments express somatostatin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb17262.x

    authors: Reubi JC,Laissue J,Waser B,Horisberger U,Schaer JC

    更新日期:1994-09-15 00:00:00

  • Vitamin A influence on calcium metabolism and calcification.

    abstract::Vitamin A deficiency has been shown to affect vision, reproduction, cellular differentiation, and maintenance of epithelial and skeletal tissues. Different vitamin A compounds, i.e., retinol and retinoic acid, vary in their ability to fulfill these biologic functions. Aside from vision, the exact molecular mechanisms ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb21326.x

    authors: Navia JM,Harris SS

    更新日期:1980-01-01 00:00:00

  • The relationship between self-esteem and depression in obese children.

    abstract::It has been suggested that obese children have increased problems with self-esteem and depression when compared to the normal pediatric population. Fifty-one consecutive patients enrolled in a hospital based weight management program received the CDI and the PHSCS as part of their initial evaluation. There were 24 mal...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb18869.x

    authors: Sheslow D,Hassink S,Wallace W,DeLancey E

    更新日期:1993-10-29 00:00:00

  • Structural and functional impact of the transgenic expression of cytokines in the CNS.

    abstract::Cytokines are powerful mediators of biologic responses in the CNS and may contribute to cellular injury in pathophysiologic states. In order to better understand the actions of cytokines in the intact mammalian CNS, a transgenic approach was employed that targeted the expression of different cytokines to astrocytes in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09552.x

    authors: Campbell IL

    更新日期:1998-05-01 00:00:00

  • New autoantibodies in pediatric opsoclonus myoclonus syndrome.

    abstract::Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1423.027

    authors: Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

    更新日期:2007-09-01 00:00:00

  • DOTS and DOTS-plus: not the only answer.

    abstract::Multidrug-resistant tuberculosis is already a global pandemic, with focal "hot spots" of ongoing transmission. Although DOTS (directly observed treatment, short course) chemotherapy is the goal of global tuberculosis control, short-course chemotherapy will not cure multidrug-resistant tuberculosis. In settings of high...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb11375.x

    authors: Farmer P

    更新日期:2001-12-01 00:00:00

  • Hair growth induction: roles of growth factors.

    abstract::The hair follicles of eutheria arise during fetal life as a consequence of interactions between the cells and matrices of the epidermis and mesenchyme. In some instances, communication may be mediated by growth factors, receptors, and similar molecules. We have focused on epidermal growth factor and fibroblast growth ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1991.tb24397.x

    authors: Moore GP,Du Cros DL,Isaacs K,Pisansarakit P,Wynn PC

    更新日期:1991-12-26 00:00:00

  • Magnetic resonance spectroscopic changes in Alzheimer's disease.

    abstract::In vitro and in vivo 31P magnetic resonance (MR) spectroscopy studies of Alzheimer's disease (AD) brain have revealed alterations in membrane phospholipid metabolism and high-energy phosphate metabolism. Mildly demented AD patients compared with control subjects have increased levels of phosphomonoesters, decreased le...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb48480.x

    authors: Pettegrew JW,Klunk WE,Panchalingam K,McClure RJ,Stanley JA

    更新日期:1997-09-26 00:00:00

  • RNA stabilization in hyperthermophilic archaea.

    abstract::Analyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA-guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC-rich regions are observed for many univers...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14060

    authors: Gomes-Filho JV,Randau L

    更新日期:2019-07-01 00:00:00