Closure, open systems, and the modeling imperative

Abstract:

:Natural systems cannot be closed to the environment. At the same time there is a necessity for closure in order to build the system. It is this quint-essential tension between openness and closure that drives systems to unfold into further stages or levels of growth and development. In other words, the emergence of organization in natural systems is a result of cycles of openness and closure. There are two distinct and complementary ways by which a system will carry over closure while involved in a process of expansion across the environment. These two ways need to be expressed in any formal representation: (1) within a level this will be by means of transitive closure, which is additive; and (2) between levels (i.e., from one level to the next higher level) this requires algebraic closure, which is multiplicative. The former expresses space closure, whereas the latter expresses topological or time closure. The conjunction of these two closures generates a hierarchy of levels. Prior to, and outside of, the system lies semantic closure.

journal_name

Ann N Y Acad Sci

authors

Alvarez De Lorenzana JM

doi

10.1111/j.1749-6632.2000.tb06268.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

91-9

eissn

0077-8923

issn

1749-6632

journal_volume

901

pub_type

杂志文章
  • Modality-dependent indication of the subjective vertical during combined linear and rotational movements.

    abstract::Humans can discriminate whether a change in the direction of gravito-inertial force (GIF) is caused by body tilt or by linear translation. This ability, attributed to vestibular sensory fusion, is often examined by asking subjects to adjust an indicator to match their subjective earth-fixed vertical (SV). We used two ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03849.x

    authors: Guenther AL,Bartl K,Nauderer J,Schneider E,Huesmann A,Brandt T,Glasauer S

    更新日期:2009-05-01 00:00:00

  • Physical exercise and antioxidant defenses in the heart.

    abstract::Cardiac muscle relies highly on aerobic metabolism. Heart muscle has a high oxygen uptake at resting conditions, which increases many fold during exhaustive physical exercise. Such a high rate of oxidative metabolism is often associated with enhanced production of reactive oxygen metabolites. A single bout of strenuou...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb09234.x

    authors: Atalay M,Sen CK

    更新日期:1999-06-30 00:00:00

  • Clara cell secretory protein (CC16): features as a peripheral lung biomarker.

    abstract::Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05520.x

    authors: Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

    更新日期:2000-01-01 00:00:00

  • New trends in astrodynamics and applications: optimal trajectories for space guidance.

    abstract::This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.002

    authors: Azimov D,Bishop R

    更新日期:2005-12-01 00:00:00

  • Prospects for single-molecule information-processing devices for the next paradigm.

    abstract::Present information technologies use semiconductor devices and magnetic/optical disks; however, they are all foreseen to face fundamental limitations within a decade. Therefore, superceding devices are required for the next paradigm of high-performance information technologies. The paper first describes architectures ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb03024.x

    authors: Wada Y

    更新日期:2002-04-01 00:00:00

  • A sex-balanced rodent model for evaluating phosphine inhalation toxicity.

    abstract::Exposure to phosphine (PH3 ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH3 poisoning is thought to target oxidative respiration, the exact mechanism of action remains largely unknown, resulting in limited treatment options. In our study, the effects ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14343

    authors: Tuet WY,Racine MC,Jennings L,Pierce SA,Tressler J,McCranor BJ,Wong B

    更新日期:2020-11-01 00:00:00

  • Proteome alterations in rat mitochondria caused by aging.

    abstract::Analysis of the protein profile of mitochondria and its age-dependent variation is a promising approach to unravel mechanisms involved in aging and age-related diseases. Our studies focus on the mammalian mitochondrial membrane proteome, especially of the inner mitochondrial membrane with the respiratory chain complex...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1395.030

    authors: Dencher NA,Frenzel M,Reifschneider NH,Sugawa M,Krause F

    更新日期:2007-04-01 00:00:00

  • Connection between the striatal neurokinin-1 receptor and nitric oxide formation during methamphetamine exposure.

    abstract::Methamphetamine (METH) is a widely used "club drug" that produces neural damage in the brain, including the loss of some neurons. METH-induced striatal neuronal loss has been attenuated by pretreatment with the neurokinin-1 receptor antagonist WIN-51,708 in mice. Using a histologic method, we have observed the interna...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.001

    authors: Wang J,Xu W,Ali SF,Angulo JA

    更新日期:2008-10-01 00:00:00

  • Evaluation of IgG antibody response against Rickettsia conorii and Rickettsia slovaca in patients with DEBONEL/TIBOLA.

    abstract::The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1374.113

    authors: Santibáñez S,Ibarra V,Portillo A,Blanco JR,Martínez de Artola V,Guerrero A,Oteo JA

    更新日期:2006-10-01 00:00:00

  • Growth activation of resting cells: induction of balanced and imbalanced growth.

    abstract::Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb43423.x

    authors: Zetterberg A,Engström W,Larsson O

    更新日期:1982-12-10 00:00:00

  • Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.

    abstract::Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05533.x

    authors: Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

    更新日期:2000-01-01 00:00:00

  • Regulatory B cells in autoimmune diseases: how do they work?

    abstract::B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04651.x

    authors: Lemoine S,Morva A,Youinou P,Jamin C

    更新日期:2009-09-01 00:00:00

  • Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution.

    abstract::The proximate hurdle for cell trafficking to any anatomic site is the initial attachment of circulating cells to target tissue endothelium with sufficient strength to overcome prevailing forces of blood flow. E-selectin, an endothelial molecule that is inducibly expressed at all sites of inflammation, is a potent effe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06421.x

    authors: Sackstein R

    更新日期:2012-04-01 00:00:00

  • Synchronization of posttranslational modifications during aging: Time is a crucial biological dimension.

    abstract::There is an urgent need for surrogate biomarkers in clinical diagnostics but also preclinical in toxicology of chemicals and efficacy testing of pharmaceuticals. On the background of the emerging fields of systems biology and theranostics, the importance of time scales and the synchronization of complex biological rea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05395.x

    authors: Schrattenholz A,Soskić V,Groebe K

    更新日期:2010-06-01 00:00:00

  • Neuroregulation of human nasal mucosa.

    abstract::Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04481.x

    authors: Baraniuk JN,Merck SJ

    更新日期:2009-07-01 00:00:00

  • Rituximab use in pediatric autoimmune diseases: four case reports.

    abstract::Rituximab (RTX) is currently used in many diseases, but its efficacy and safety in juvenile systemic lupus erythematosus (SLEj) is still unknown. In this chapter we present four case reports of children treated with RTX: three SLE and one immune thrombocytopenic purpura (ITP). Two of the three SLEj patients had class ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04804.x

    authors: Polido-Pereira J,Ferreira D,Rodrigues AM,Nascimento C,Costa P,Almeida M,da Silva JE,Simão C,Stone R,Ramos F,Neto A,da Costa JC,Melo-Gomes J,Gomes-Pedro J,Viana-Queiroz M,Canhão H,Fonseca JE

    更新日期:2009-09-01 00:00:00

  • Effects of retinal image slip on modulation of visual vestibulo-ocular reflex during near viewing.

    abstract::During viewing of a near target, the gain of the visually modulated vestibulo-ocular reflex (vVOR) exceeds 1.0. We investigated whether retinal image slip contributes to this gain increase by measuring responses during strobe illumination. Subjects showed greater gain values during normal versus strobe illumination of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.045

    authors: Han YH,Kumar AN,Somers JT,Reschke MF,Leigh RJ

    更新日期:2005-04-01 00:00:00

  • The Caribbean Amblyomma Program: some ecologic factors affecting its success.

    abstract::The Caribbean Amblyomma Program has been operational for 8 years. However, owing to funding availability, some islands did not commence eradication activities until late 1997. During the past 2 years, 6 of the 9 islands (St. Kitts, St. Lucia, Anguilla, Montserrat, Barbados, and Dominica) under the program have attaine...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1307.056

    authors: Pegram R,Indar L,Eddi C,George J

    更新日期:2004-10-01 00:00:00

  • The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistance.

    abstract::The development of glucocorticoid (GC) resistance is a serious problem that complicates the treatment of immune-related diseases, such as asthma, ulcerative colitis, and hematologic cancers. hGRalpha and hGRbeta are two isoforms of the human glucocorticoid receptor, which differ in the structural composition of the ca...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1351.001

    authors: Lewis-Tuffin LJ,Cidlowski JA

    更新日期:2006-06-01 00:00:00

  • Speech rhythm as naturally occurring and culturally transmitted behavioral patterns.

    abstract::Rhythm is fundamental to every motor activity. Neural and physiological mechanisms that underlie rhythmic cognition, in general, and rhythmic pattern generation, in particular, are evolutionarily ancient. As speech production is a kind of motor activity, investigating speech rhythm can provide insight into how general...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14234

    authors: Ordin M

    更新日期:2019-10-01 00:00:00

  • Protein oxidation.

    abstract::The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases. These reactive species form through a large number of physiological and non-physiological reactions. An increase in the rate of their prod...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06187.x

    authors: Stadtman ER,Levine RL

    更新日期:2000-01-01 00:00:00

  • NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells.

    abstract::It is thought that human natural killer (NK) lymphocytes should not damage self-tissues due to the inhibiting signal initiated by the engagement of one or another inhibitory receptor superfamily (IRS) members with self-human histocompatibility antigen (HLA)-I. During viral infection, the low expression of self-HLA-I o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1398.007

    authors: Poggi A,Prevosto C,Zancolli M,Canevali P,Musso A,Zocchi MR

    更新日期:2007-08-01 00:00:00

  • Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse.

    abstract::In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05154.x

    authors: Chen BT,Hopf FW,Bonci A

    更新日期:2010-02-01 00:00:00

  • Identification of thrombin antibodies in patients with antiphospholipid syndrome.

    abstract::Venous or arterial thrombosis, abortion, and the presence of antiphospholipid antibodies (aPL) define the criteria for the antiphospholipid syndrome (APS). A heterogeneous group of antibodies against phospholipids and plasma proteins may influence several coagulation pathways and lead to thrombophilia. We investigated...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1313.026

    authors: Miesbach W,Matthias T,Scharrer I

    更新日期:2005-06-01 00:00:00

  • Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Granulomas as potential lymphoid tissue maintaining autoantibody production.

    abstract::In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1361.042

    authors: Voswinkel J,Müller A,Lamprecht P

    更新日期:2005-06-01 00:00:00

  • Role of nitric oxide and alcohol on gonadotropin release in vitro and in vivo.

    abstract::Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09562.x

    authors: Rettori V,McCann SM

    更新日期:1998-05-01 00:00:00

  • Characterization of a leukocyte-derived endogenous mediator responsible for increased plasma fibrinogen.

    abstract::Fibrinogen has been the plasma protein most frequently studied after tissue injury. This report presents evidence that leukocytic endogenous mediator (LEM) from macrophages promotes fibrinogen synthesis. LEM has a molecular weight of 13,000-16,000, an isoelectric point (pI) at pH 7.3, is heat labile, and is inactivate...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1982.tb22148.x

    authors: Kampschmidt RF,Upchurch HF,Pulliam LA

    更新日期:1982-01-01 00:00:00

  • Role of pituitary adenylate cyclase-activating polypeptide in the pancreatic endocrine system.

    abstract::In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in beta cells and autonomic nerve terminals; the majority of these nerve terminals are parasympathetic. PACAP binds to three types of G protein-coupled receptors (GPCRs): VPAC1 receptors, VPAC2 receptors, and PAC1 recepto...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1418.003

    authors: Ahrén B

    更新日期:2008-11-01 00:00:00

  • A systematic-heuristic approach for space trajectory design.

    abstract::In this paper a novel algorithm is proposed for space trajectory design that combines a systematic and a heuristic method for global optimization. For the systematic part of the algorithm a branching technique is used, whereas a particular implementation of evolution programming forms the core of the heuristic part. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1311.014

    authors: Vasile M

    更新日期:2004-05-01 00:00:00

  • The antioxidative effect of carboxyfullerenes (C3/D3) on iron-induced oxidative injury in CNS.

    abstract::Carboxyfullerenes, including two regioisomers C3 and D3, were investigated as antioxidants against iron-induced oxidative stress in vivo and in vitro. Both C3 and D3 dose-dependently inhibited autoxidation and iron-elevated lipid peroxidation in cortical homogenates. The antioxidative property of C3 was compared to Tr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08012.x

    authors: Lin AM,Luh TY,Chou CK,Ho LT

    更新日期:1999-01-01 00:00:00