A novel caries risk test.

abstract：:Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...

journal_title：Annals of the New York Academy of Sciences

authors： Stokbro K,Taylor J,Brandbyge M,Ordejón P

更新日期：2003-12-01 00:00:00

abstract：:Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of ch...

journal_title：Annals of the New York Academy of Sciences

authors： Ginter E

更新日期：1975-09-30 00:00:00

abstract：:Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the...

journal_title：Annals of the New York Academy of Sciences

authors： Donnelly RP,Young HA,Rosenberg AS

更新日期：2009-12-01 00:00:00

abstract：:The perceptions of coccidioidomycosis as a medical problem has undergone sequential and dramatic metamorphoses since its first description more than a century ago. First thought to be rare and lethal, coccidioidomycosis was subsequently found to be common and often mild. During World War II, its overall impact upon la...

journal_title：Annals of the New York Academy of Sciences

authors： Galgiani JN

更新日期：2007-09-01 00:00:00

abstract：:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable h...

journal_title：Annals of the New York Academy of Sciences

authors： Michnovicz JJ,Bradlow HL

更新日期：1990-01-01 00:00:00

abstract：:Endothelial cells produce and bind to multiple basement membrane components. Fibronectin and interstitial collagens seem to promote migration and proliferation, whereas basement membrane collagen and laminin stimulate attachment and differentiation. Human umbilical vein endothelial cells will rapidly form capillary-li...

journal_title：Annals of the New York Academy of Sciences

authors： Grant DS,Kleinman HK,Martin GR

更新日期：1990-01-01 00:00:00

abstract：:Language and music are human universals involving perceptually discrete elements organized in hierarchically structured sequences. The set of principles governing the combination of these structural elements into sequences is known as syntax. A violation of expectancies concerning syntactic regularities may be reflect...

journal_title：Annals of the New York Academy of Sciences

authors： Jentschke S,Koelsch S,Friederici AD

更新日期：2005-12-01 00:00:00

abstract：:Our studies have shown that the acyclic nucleotide analogues PMEA and HPMPC are able to penetrate into cells and are then activated to mono- and diphosphate derivatives. The latter correspond to triphosphate analogues and presumably serve an important role in the biological activity exerted by these antiviral agents. ...

journal_title：Annals of the New York Academy of Sciences

authors： Bronson JJ,Ho HT,De Boeck H,Woods K,Ghazzouli I,Martin JC,Hitchcock MJ

更新日期：1990-01-01 00:00:00

abstract：:Cardiac afferent neurons are activated in the setting of myocardial ischemia and mediate the sensation of angina. However, the precise stimuli and receptive molecules responsible are not completely understood. To further investigate the molecular components involved, cardiac afferents were isolated in dissociated cult...

journal_title：Annals of the New York Academy of Sciences

authors： Benson CJ,Sutherland SP

更新日期：2001-06-01 00:00:00

abstract：:The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovari...

journal_title：Annals of the New York Academy of Sciences

authors： Kalantaridou SN,Chrousos GP

更新日期：2000-01-01 00:00:00

abstract：:Transcriptional profiling and functional genomics experiments using E11.5 metanephros organ cultures from Ahr(-/-) and Ahr(+/+) have shown that aryl hydrocarbon receptor (AHR) transcription factor is involved in the regulation of mesenchymal-to-epithelial transition (MET) during nephrogenesis. This response is mediate...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos KS

更新日期：2006-09-01 00:00:00

abstract：:Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

journal_title：Annals of the New York Academy of Sciences

authors： Lawn P

更新日期：2011-02-01 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produc...

journal_title：Annals of the New York Academy of Sciences

authors： Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

更新日期：2020-11-01 00:00:00

abstract：:Altered tissue-specific processing or production of the amyloid precursor protein (APP) is thought to be central to amyloid deposition in cerebrovascular and the neocortical tissues in Alzheimer's disease (AD). We demonstrate that A beta peptide(s) is readily detectable and increased in cerebral vessels, meninges and ...

journal_title：Annals of the New York Academy of Sciences

authors： Premkumar DR,Kalaria RN

更新日期：1996-01-17 00:00:00

abstract：:Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory-activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back-labeled funicular pathways suggest t...

journal_title：Annals of the New York Academy of Sciences

authors： Lev-Tov A,Etlin A,Blivis D

更新日期：2010-06-01 00:00:00

abstract：:The principal modulators of the hypothalamic-pituitary-adrenal (HPA) axis are corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP). Corticotropin-releasing hormone is not exclusively produced in the hypothalamus. Its presence has been demonstrated at peripheral inflammatory sites. Ovulation and luteoly...

journal_title：Annals of the New York Academy of Sciences

authors： Mastorakos G,Ilias I

更新日期：2003-11-01 00:00:00

abstract：:Coccidioidomycosis is a potentially serious fungal infection contracted in endemic areas of the desert southwestern United States. Limited information exists about its incidence and clinical course in patients with rheumatic diseases, who may be at higher risk of symptomatic or disseminated coccidioidomycosis because ...

journal_title：Annals of the New York Academy of Sciences

authors： Mertz LE,Blair JE

更新日期：2007-09-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cell...

journal_title：Annals of the New York Academy of Sciences

authors： Unger WW,Pinkse GG,Mulder-van der Kracht S,van der Slik AR,Kester MG,Ossendorp F,Drijfhout JW,Serreze DV,Roep BO

更新日期：2007-04-01 00:00:00

abstract：:Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the world's population. The number of diabetic patients will reach 300 million in 2025 (International Diabetes Federation, 2001). More than 97% of these patients will have type II diabetes. The projected increase in the number of di...

journal_title：Annals of the New York Academy of Sciences

authors： Adeghate E,Schattner P,Dunn E

更新日期：2006-11-01 00:00:00

abstract：:A cholinergic hypofunction in Alzheimer's disease (AD) may lead to formation of beta-amyloids that might impair the coupling of M1 muscarinic ACh receptors (mAChRs) with G proteins. This disruption in coupling can lead to decreased signal transduction, to a reduction in levels of trophic amyloid precursor proteins (AP...

journal_title：Annals of the New York Academy of Sciences

authors： Fisher A,Michaelson DM,Brandeis R,Haring R,Chapman S,Pittel Z

更新日期：2000-01-01 00:00:00

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:Young songbirds memorize a tutor song and use the memory trace as a template to shape their own song by auditory feedback. Major issues in birdsong research include the neural sites and mechanisms for song memory and auditory feedback. The brain song control system contains neurons with both premotor and auditory func...

journal_title：Annals of the New York Academy of Sciences

authors： Konishi M

更新日期：2004-06-01 00:00:00

abstract：:Red spruce (Picea rubens Sarg.) and balsam fir (Abies balsamea (L.) Mill.) were present by 13,700 years B.C.E. in the Catskills Mountains of southeastern New York State. These conifers were, and still are, largely confined to the eastern and far western portions of the region. A gap in the distribution exists between ...

journal_title：Annals of the New York Academy of Sciences

authors： Kudish M

更新日期：2013-09-01 00:00:00

abstract：:Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeos...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta S,Gollapudi S

更新日期：2007-08-01 00:00:00

abstract：:Methamphetamine (METH), a highly addictive drug, can cause degeneration of monoaminergic terminals and neuronal apoptosis in the mammalian brain. In the present article, we have used serial analysis of gene expression (SAGE) to investigate patterns of gene expression in the striata of rats that were given a neurotoxic...

journal_title：Annals of the New York Academy of Sciences

authors： Cai NS,McCoy MT,Ladenheim B,Lyles J,Ali SF,Cadet JL

更新日期：2006-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic joint inflammation and continuous immune cell infiltration in the synovium. These changes are linked to inflammatory cytokine release, leading to eventual destruction of cartilage and bone. During the last decade new therapeutic modalities ha...

journal_title：Annals of the New York Academy of Sciences

authors： Marti L,Golmia R,Golmia AP,Paes AT,Guilhen DD,Moreira-Filho CA,Scheinberg M

更新日期：2009-09-01 00:00:00

abstract：:Modern contraceptive methods represent more than a technical advance: they are the instrument of a true social revolution-the "first reproductive revolution" in the history of humanity, an achievement of the second part of the 20th century, when modern, effective methods became available. Today a great diversity of te...

journal_title：Annals of the New York Academy of Sciences

authors： Benagiano G,Bastianelli C,Farris M

更新日期：2006-12-01 00:00:00

abstract：:The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2...

journal_title：Annals of the New York Academy of Sciences

authors： Gonzalez C,Vaquero LM,López-López JR,Pérez-García MT

更新日期：2009-10-01 00:00:00

abstract：:The classic cardiac research programs revolved around measurable properties such as pressures, work done, vascular blood flow, electrical propagation, and other such parameters that defined the global heart functions in health and decease. Consistently, the first Henry Goldberg Workshop, held in Haifa in 1984, focused...

journal_title：Annals of the New York Academy of Sciences

authors： Beyar R

更新日期：2005-06-01 00:00:00