Autologous hematopoietic stem cell transplantation for type 1 diabetes.

abstract：:Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders that cause individuals to be prone to a variety of clinical manifestations, such as infections, autoimmunity, and malignancies. Early diagnosis and adequate treatment of these disorders can reduce morbidity and mortality and prov...

journal_title：Annals of the New York Academy of Sciences

authors： Rezaei N,Mohammadinejad P,Aghamohammadi A

更新日期：2011-11-01 00:00:00

abstract：:The effects of TCDD exposure on the developing immune system were investigated in Wistar/Fischer hybrid or Fischer rats. Fetal and neonatal rats were exposed to TCDD through maternal dosing (5 muk/kg) on day 18 of gestation and on days 0, 7, and 14 of postnatal life (group 1). Another group of neonatal rats was expose...

journal_title：Annals of the New York Academy of Sciences

authors： Luster MI,Faith RE,Clark G

更新日期：1979-05-31 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:Sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation, "Advancing Drug Discovery for Schizophrenia" was held March 9-11 at the New York Academy of Sciences in New York City. The meeting, comprisi...

journal_title：Annals of the New York Academy of Sciences

authors： Marder SR,Roth B,Sullivan PF,Scolnick EM,Nestler EJ,Geyer MA,Welnberger DR,Karayiorgou M,Guidotti A,Gingrich J,Akbarian S,Buchanan RW,Lieberman JA,Conn PJ,Haggarty SJ,Law AJ,Campbell B,Krystal JH,Moghaddam B,Sawa A

更新日期：2011-10-01 00:00:00

abstract：:Several reports addressed the issue of how the alternative splicing of exon 7 and 8 in the APP pre-mRNA is regulated in different tissues. Of special interest here was the potential involvement of exon 7 containing APP splice isoforms, since this exon codes for a serine protease inhibitor and is therefore of putative ...

journal_title：Annals of the New York Academy of Sciences

authors： Sandbrink R,Banati R,Masters CL,Beyreuther K,König G

更新日期：1993-09-24 00:00:00

abstract：:Ruminants are widespread in hot, arid regions. This demands adaptation to large circadian temperature fluctuations and recurrent periods of food and water shortage. Pregnancy and lactation add to the demands on the adaptive mechanisms due to the greater need for food, water, and electrolytes. The blood volume increase...

journal_title：Annals of the New York Academy of Sciences

authors： Olsson K

更新日期：2005-04-01 00:00:00

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：:The entry of resting T cells into the G1 phase of the cell cycle after stimulation by mitogens is controlled by a series of biochemical events that are independent of growth factors. These events follow the initial signals stimulated through the engagement of the T-cell receptor and include activation of the cyclin-de...

journal_title：Annals of the New York Academy of Sciences

authors： Modiano JF,Domenico J,Szepesi A,Terada N,Lucas JJ,Gelfand EW

更新日期：1995-09-07 00:00:00

abstract：:Expectation of reward facilitates motor behaviors that enable the animal to approach a location in space where the reward is expected. It is now known that the same expectation of reward profoundly modifies sensory, motor, and cognitive information processing in the brain. However, it is still unclear which brain regi...

journal_title：Annals of the New York Academy of Sciences

authors： Hikosaka O

更新日期：2007-05-01 00:00:00

abstract：:One of the richest reservoirs of antibiotic-resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture-based genomic technology and culture-independent metagenomics have been developed to investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Su JQ,Cui L,Chen QL,An XL,Zhu YG

更新日期：2017-01-01 00:00:00

abstract：:Like other somatic cells, human T lymphocytes have a finite replicative capacity in vitro, and, by implication and consistent with the limited data available, in vivo as well. An accumulation of dysfunctional T cells may be detrimental under conditions of chronic antigenic stress (chronic infection, cancer, autoimmuni...

journal_title：Annals of the New York Academy of Sciences

authors： Pawelec G,Mariani E,McLeod J,Ben-Yehuda A,Fulop T,Aringer M,Barnett Y

更新日期：2004-06-01 00:00:00

abstract：:Evolutionary theory is undergoing an intense period of discussion and reevaluation. This, contrary to the misleading claims of creationists and other pseudoscientists, is no harbinger of a crisis but rather the opposite: the field is expanding dramatically in terms of both empirical discoveries and new ideas. In this ...

journal_title：Annals of the New York Academy of Sciences

authors： Pigliucci M

更新日期：2009-06-01 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:The injury to vascular endothelium seen in severe bacterial infection may be mediated by neutrophil-derived enzymes. Neutrophil adhesion to endothelium, a prerequisite for this process, is mediated sequentially by the leukocyte adhesion molecules L-selectin and the beta 2 integrins, including CD11b/CD18. We have explo...

journal_title：Annals of the New York Academy of Sciences

authors： Finn A,Strobel S,Levin M,Klein N

更新日期：1994-05-28 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:The free radical theory of aging proposes that oxidative stress is one of the determinants of an organism's life span. In Caenorhabditis elegans, genetic or environmental changes have been shown to modulate life span. Here we discuss whether changes in the generation and destruction of free radicals are implicated in ...

journal_title：Annals of the New York Academy of Sciences

authors： Honda Y,Honda S

更新日期：2002-04-01 00:00:00

abstract：:Mouse models with targeted deletion of the genes encoding the enzyme 25-hydroxyvitamin D 1alpha-hydroxylase [1alpha(OH)ase], and the vitamin D receptor (VDR), have provided considerable insight into the regulation of mineral and skeletal physiology by 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Dietary manipulation induce...

journal_title：Annals of the New York Academy of Sciences

authors： Goltzman D

更新日期：2010-03-01 00:00:00

abstract：:Why does music pervade our lives and those of all known human beings living today and in the recent past? Why do we feel compelled to engage in musical activity, or at least simply enjoy listening to music even if we choose not to actively participate? I argue that this is because musicality--communication using varia...

journal_title：Annals of the New York Academy of Sciences

authors： Mithen S

更新日期：2009-07-01 00:00:00

abstract：:Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younge...

journal_title：Annals of the New York Academy of Sciences

authors： Landin-Olsson M

更新日期：2002-04-01 00:00:00

abstract：:The recent identification of tumor-associated antigens (TAA) and TAA-derived peptides presented by MHC molecules to T cells has provided the tools to design and test clinical vaccines for treating human malignancies, such as melanoma. While the most effective adjuvant for use in vaccine formulation remains unclear, au...

journal_title：Annals of the New York Academy of Sciences

authors： Zitvogel L,Couderc B,Mayordomo JI,Robbins PD,Lotze MT,Storkus WJ

更新日期：1996-10-31 00:00:00

abstract：:Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation respo...

journal_title：Annals of the New York Academy of Sciences

authors： Kraft DC,Deocaris CC,Rattan SI

更新日期：2006-05-01 00:00:00

abstract：:The structure of a growing number of glycation and advanced glycation end products has been elucidated. Measuring these products can be used to assess cumulative glycemic and glycoxidative damage in diabetes and other chronic conditions. The predictive power of a given glycation product can be tested in large prospect...

journal_title：Annals of the New York Academy of Sciences

authors： Monnier VM,Sell DR,Genuth S

更新日期：2005-06-01 00:00:00

abstract：:Artificial neural network (ANN) technology is finding increasing application in medicine and biomedical engineering. This paper supplies necessary background in ANN technology for researchers unfamiliar with this rapidly emerging discipline. This introduction to ANN application is cast in the context of epileptic seiz...

journal_title：Annals of the New York Academy of Sciences

authors： Hand C

更新日期：2002-12-01 00:00:00

abstract：:One of the most important advances in perinatal health care is the use of antepartum fetal testing. Antepartum fetal testing methods may include inexpensive tests such as fetal kick counts or tests that can be quite expensive such as non-stress tests, fetal biophysical profiles, and Doppler assessments as well as inva...

journal_title：Annals of the New York Academy of Sciences

authors： Vintzileos AM

更新日期：2000-01-01 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:The current trend in antipoverty policy emphasizes mandated empowerment: the poor are being handed the responsibility for making things better for themselves, largely without being asked whether this is what they want. Beneficiary control is now being built into public service delivery, while microcredit and small bus...

journal_title：Annals of the New York Academy of Sciences

authors： Banerjee AV,Duflo E

更新日期：2008-01-01 00:00:00

abstract：:Our paper reviews recent progress in the study and understanding of observed trends in extreme rainfall events in the Metropolitan Area of São Paulo (MASP). These are discussed in relation to hydrometeorological hazards that trigger natural disasters, such as flash floods, landslides, and droughts, that affect the pop...

journal_title：Annals of the New York Academy of Sciences

authors： Marengo JA,Alves LM,Ambrizzi T,Young A,Barreto NJC,Ramos AM

更新日期：2020-07-01 00:00:00

abstract：:We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A ca...

journal_title：Annals of the New York Academy of Sciences

authors： Duguid JR,Trzepacz C,Kemper T,Tourtellote WW,Volicer L

更新日期：1993-05-28 00:00:00

abstract：:The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective trea...

journal_title：Annals of the New York Academy of Sciences

authors： Leigh RJ,Das VE,Seidman SH

更新日期：2002-04-01 00:00:00