Spinal plasticity following intermittent hypoxia: implications for spinal injury.

Abstract:

:Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain-derived neurotrophic factor, activation of its high-affinity receptor, tropomyosin-related kinase B, and extracellular-related kinase mitogen-activated protein kinase signaling in or near phrenic motor neurons. Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury. Because repetitive AIH induces phenotypic plasticity in respiratory motor neurons, it may restore respiratory motor function in patients with incomplete spinal injury.

journal_name

Ann N Y Acad Sci

authors

Dale-Nagle EA,Hoffman MS,MacFarlane PM,Satriotomo I,Lovett-Barr MR,Vinit S,Mitchell GS

doi

10.1111/j.1749-6632.2010.05499.x

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

252-9

eissn

0077-8923

issn

1749-6632

pii

NYAS5499

journal_volume

1198

pub_type

杂志文章,评审
  • Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters.

    abstract::The aim of this study was to examine changes in muscle cell injury and antioxidant capacity of weightlifters following a 1-week intensive resistance-training regimen. Thirty-six female subjects participated in this study, and their ages ranged from 18 to 25 years. The sample group included 19 elite weightlifters with ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1338.029

    authors: Liu JF,Chang WY,Chan KH,Tsai WY,Lin CL,Hsu MC

    更新日期:2005-05-01 00:00:00

  • A dietary supplement improves outcome in an experimental influenza model in old mice.

    abstract::Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1354.059

    authors: Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

    更新日期:2006-05-01 00:00:00

  • The role of arginine vasopressin on peripheral cardiac parasympathetic nerve function in the rat.

    abstract::In rats, arginine vasopressin augments bradycardia associated with baroreflex activation. We investigated whether modulation of peripheral cardiac parasympathetic nerve function by AVP may play a role in this effect. To accomplish this we utilized an in vivo model with which we previously demonstrated both adrenergic ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb55560.x

    authors: Pardini BJ,Lund DD,Schmid PG

    更新日期:1993-07-22 00:00:00

  • Shikonin production by extractive cultivation in transformed-suspension and hairy root cultures of Lithospermum erythrorhizon.

    abstract::Effects of in situ extraction, fungal elicitation, a permeabilizing agent, and the oxygen transfer rate on shikonin production in transformed suspension and hairy root cultures of Lithospermum erythrorhizon were studied. Shikonin production with in situ extraction in transformed cell and hairy root cultures by n-hexad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb44395.x

    authors: Sim SJ,Kim DJ,Chang HN

    更新日期:1994-11-30 00:00:00

  • End-plate potentials in experimental autoimmune myasthenia gravis in rats.

    abstract::Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47694.x

    authors: Lambert EH,Lindstrom JM,Lennon VA

    更新日期:1976-01-01 00:00:00

  • Thymosin beta4 is cardioprotective after myocardial infarction.

    abstract::Heart disease is a leading cause of death in newborns and in adults. Efforts to promote cardiac repair by introduction or recruitment of exogenous stem cells hold promise but typically involve isolation and introduction of autologous or donor progenitor cells. We have found that the G-actin-sequestering peptide thymos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1415.048

    authors: Srivastava D,Saxena A,Michael Dimaio J,Bock-Marquette I

    更新日期:2007-09-01 00:00:00

  • Renal tubule sodium transporter abundance profiling in rat kidney: response to aldosterone and variations in NaCl intake.

    abstract::Based on extensive physiological study of sodium transport mechanisms along the renal tubule, complementary DNAs for all of the major transporters and channels responsible for renal tubular sodium reabsorption have been cloned over the past decade. There is now a comprehensive set of cDNA and antibody probes that can ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07254.x

    authors: Knepper MA,Kim GH,Masilamani S

    更新日期:2003-04-01 00:00:00

  • Interaction of fibrinogen with staphylococcal clumping factor and with platelets.

    abstract::Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb23270.x

    authors: Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

    更新日期:1983-06-27 00:00:00

  • Determining pathway structure-property relationships through experimentation and analytical frameworks.

    abstract::A brief description of the information content of the experimental methods that are becoming increasingly useful for probing intracellular processes, a framework for interpreting observations, and an example that combines framework results and 13C NMR observations have been presented. Results in terms of structural cr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb23813.x

    authors: Domach MM,Majewski RA

    更新日期:1987-01-01 00:00:00

  • "Serious" mental retardation in developing countries: an epidemiologic approach.

    abstract::In this paper we first present methods and preliminary results of pilot surveys of "serious" mental retardation (IQ less than or equal to 55); the surveys included screening and diagnostic components and were carried out in the less-developed world. Next we discuss two problems raised by these surveys: one is the diag...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb40316.x

    authors: Stein Z,Durkin M,Belmont L

    更新日期:1986-01-01 00:00:00

  • Neurophysiological models for new treatment development in schizophrenia: early sensory approaches.

    abstract::Schizophrenia is a major mental disorder associated with core neurocognitive impairments. The ability to recreate these deficits in animal models is limited, hampering ongoing translational drug development efforts. This paper reviews the use of electroencephalography (EEG)-based neurophysiological measures, such as e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12689

    authors: Javitt DC

    更新日期:2015-05-01 00:00:00

  • Osteopontin expression in cardiovascular diseases.

    abstract::Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb44624.x

    authors: Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

    更新日期:1995-04-21 00:00:00

  • The transfer of immunity from mother to child.

    abstract::The newborn's immune system grows fast from a small size at birth by exposure primarily to the intestinal microflora normally obtained from the mother at and after birth. While building up its immune system, the infant is supported by the transplacental IgG antibodies, which also contain anti-idiotypic antibodies, pos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb06049.x

    authors: Hanson LA,Korotkova M,Lundin S,Håversen L,Silfverdal SA,Mattsby-Baltzer I,Strandvik B,Telemo E

    更新日期:2003-04-01 00:00:00

  • Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances.

    abstract::Syndrome X is a clinical syndrome in which multiple risks cluster in an individual, and it is a common basis of vascular disease in the industrial countries. The molecular basis of Syndrome X, however, has not been elucidated. We have analyzed body fat distribution using CT scan and have shown that people who have acc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07793.x

    authors: Matsuzawa Y,Funahashi T,Nakamura T

    更新日期:1999-11-18 00:00:00

  • Assessment of climate-coccidioidomycosis model: model sensitivity for assessing climatologic effects on the risk of acquiring coccidioidomycosis.

    abstract::Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1406.024

    authors: Comrie AC,Glueck MF

    更新日期:2007-09-01 00:00:00

  • Some scientific and organizational challenges in cancer immunology.

    abstract::This volume provides a small sampling of the rapidly growing science of cancer immunology. Growth in the field includes advances on the requirements for immunization or vaccination and the ways in which immunity can be suppressed or blocked, including active tumor-based mechanisms. I would like to introduce the papers...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2009.05060.x

    authors: Steinman RM

    更新日期:2009-09-01 00:00:00

  • Does the expression of c-kit (CD117) in neuroendocrine tumors represent a target for therapy?

    abstract::Neuroendocrine tumors are very heterogeneous, develop from a variety of tissues, and can be difficult to diagnose. Without the clinical manifestation of metastases, it is often difficult to characterize them as malignant. Even so-called completely (R0) resected tumors can spread clinically visible metastases within a ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1353.055

    authors: Koch CA,Gimm O,Vortmeyer AO,Al-Ali HK,Lamesch P,Ott R,Kluge R,Bierbach U,Tannapfel A

    更新日期:2006-08-01 00:00:00

  • Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals.

    abstract::Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14475

    authors: Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

    更新日期:2020-11-01 00:00:00

  • Cell-cell interactions and the regulation of testis function.

    abstract::Regulatory interactions have been shown to occur between all the testicular cell types considered. The paracrine factors mediating these interactions generally influence either cellular growth or differentiation. The regulation of cellular growth is essential in the developing testis and is required for the maintenanc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1991.tb27322.x

    authors: Skinner MK,Norton JN,Mullaney BP,Rosselli M,Whaley PD,Anthony CT

    更新日期:1991-01-01 00:00:00

  • Physiology and pathophysiology of Parkinson's disease.

    abstract::The behavior of neurons in the basal ganglia is severely disrupted in Parkinson's disease (PD). In nonhuman parkinsonian primate models, the disturbance in neurons in basal ganglia output structures include increased firing, bursting, an augmented synchrony, correlated activity, and a tendency towards loss of specific...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07459.x

    authors: Hamani C,Lozano AM

    更新日期:2003-06-01 00:00:00

  • Development of second-order vestibular projections in the chicken embryo.

    abstract::The results reviewed here demonstrate that vestibulospinal and vestibulo-ocular interneurons in the chicken embryo are organized into coherent clusters, each of which occupies a unique spatial domain and has a characteristic axon trajectory. Moreover, the vestibulo-ocular clusters have specific termination patterns in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1996.tb15689.x

    authors: Glover JC

    更新日期:1996-06-19 00:00:00

  • Dynamics of the transition from osteoblast to osteocyte.

    abstract::Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone. However, the mechanisms that control the differentiation of osteoblasts into osteocytes embedded in bone matrix are not well understood. With the recent developments of transgenic models for manipulating gene expression in osteocytes an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05246.x

    authors: Dallas SL,Bonewald LF

    更新日期:2010-03-01 00:00:00

  • The transforming growth factor-betas. A new family of immunoregulatory molecules.

    abstract::Within the past three years there has been a rapid expansion in our knowledge of the role TGF-beta mediates in regulating immune responses in vitro. Whether the TGF-beta will be clinically useful to suppress immune responses to transplanted organs or autoimmune responses is unknown. However, now that highly purified q...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb16110.x

    authors: Palladino MA,Morris RE,Starnes HF,Levinson AD

    更新日期:1990-01-01 00:00:00

  • Multi-scale model of O2 transport and metabolism: response to exercise.

    abstract::Regulation of pulmonary oxygen uptake (VO2p) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.021

    authors: Zhou H,Lai N,Saidel GM,Cabrera ME

    更新日期:2008-03-01 00:00:00

  • Measurement of thermal diffusivity of bovine aorta subject to finite deformation.

    abstract::The flash thermal diffusivity measurement technique is applied to tissue for the first time. Making use of its minimal contact with the specimen, the flash technique is extended to allow for well-defined, biaxial, finite strain. As an example application, the radial component of thermal diffusivity of bovine descendin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10143.x

    authors: Doss DJ,Humphrey JD,Wright NT

    更新日期:1998-09-11 00:00:00

  • Food security, poverty, and human development in the United States.

    abstract::Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child-referenced items now make...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1425.001

    authors: Cook JT,Frank DA

    更新日期:2008-01-01 00:00:00

  • Past and present national tick control programs. Why they succeed or fail.

    abstract::The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05334.x

    authors: Pegram RG,Wilson DD,Hansen JW

    更新日期:2000-01-01 00:00:00

  • Transition to turbulence under low-pressure turbine conditions.

    abstract::In this paper, the topic of laminar to turbulent flow transition, as applied to the design of gas turbines, is discussed. Transition comes about when a flow becomes sufficiently unstable that the orderly vorticity structure of the laminar layer becomes randomly oriented. Vorticity with a streamwise component leads to ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb05841.x

    authors: Simon TW,Kaszeta RW

    更新日期:2001-05-01 00:00:00

  • Bacterial cellulose hydrolysis in anaerobic environmental subsystems--Clostridium thermocellum and Clostridium stercorarium, thermophilic plant-fiber degraders.

    abstract::Cellulose degradation is a rare trait in bacteria. However, the truly cellulolytic bacteria are extremely efficient hydrolyzers of plant cell wall polysaccharides, especially those in thermophilic anaerobic ecosystems. Clostridium stercorarium, a thermophilic ubiquitous soil dweller, has a simple cellulose hydrolyzing...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1419.008

    authors: Zverlov VV,Schwarz WH

    更新日期:2008-03-01 00:00:00

  • Velocity storage in labyrinthine disorders.

    abstract::We studied 13 patients with unilateral peripheral vestibular lesions following removal of acoustic neurinomas. The time constant of the VOR after surgery was 6.4 +/- 2.6 seconds (normal is 18.5 +/- 7.7 seconds). The time constant of OKAN after surgery was 7.2 +/- 1.8 seconds (normal is 11.3 +/- 3.2 seconds). The mean ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb25216.x

    authors: Hain TC,Zee DS

    更新日期:1992-05-22 00:00:00