Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes.

abstract：:CD40 ligand (CD40L) is expressed by activated T cells and interacts with the CD40 molecule present on B cells and endothelial cells, promoting immunoglobulin switching in the former and cytokine upregulation in the latter. CD40L exists in both a soluble (sCD40L) and a membrane-bound form. Because primary biliary cirrh...

journal_title：Annals of the New York Academy of Sciences

authors： Oertelt S,Invernizzi P,Selmi C,Podda M,Gershwin ME

更新日期：2005-06-01 00:00:00

abstract：:The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

journal_title：Annals of the New York Academy of Sciences

authors： Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

更新日期：2003-05-01 00:00:00

abstract：:The human spatial orientation system is highly complex and nonlinear. It is difficult, therefore, to arrive at an unequivocal model of the underlying processing by merely combining the known elementary mechanisms ("bottom-up" approach); additional "top-down" concepts are required to narrow the choice between several f...

journal_title：Annals of the New York Academy of Sciences

authors： Mergner T,Becker W

更新日期：2003-10-01 00:00:00

abstract：:Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co-receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generat...

journal_title：Annals of the New York Academy of Sciences

authors： Ishii H,Yoshida M,Hajjar KA,Tanaka A,Yasukochi Y,Shimokado K,Numano F

更新日期：2001-12-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:Structural analysis of secretin in solution has demonstrated extended helical domains within both amino- and carboxyl-terminal halves, with a possible turn in between. However, the conformation of this peptide as it resides in its binding site within the receptor has not been established. In the work reported here, we...

journal_title：Annals of the New York Academy of Sciences

authors： Dong M,Wang Y,Miller LJ

更新日期：2000-01-01 00:00:00

abstract：:Currently up to one-third of colorectal cancer patients present with locally advanced or metastatic disease that precludes a surgical cure. Performance limitations and low uptake of current screening tools have fueled research to develop minimally invasive approaches that can detect early-stage neoplasms. The observat...

journal_title：Annals of the New York Academy of Sciences

authors： Jubb AM,Quirke P,Oates AJ

更新日期：2003-03-01 00:00:00

abstract：:Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

journal_title：Annals of the New York Academy of Sciences

authors： Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

更新日期：2011-03-01 00:00:00

abstract：:A brief description of the information content of the experimental methods that are becoming increasingly useful for probing intracellular processes, a framework for interpreting observations, and an example that combines framework results and 13C NMR observations have been presented. Results in terms of structural cr...

journal_title：Annals of the New York Academy of Sciences

authors： Domach MM,Majewski RA

更新日期：1987-01-01 00:00:00

abstract：:In the light of results of clinical trials with immunoisolated human parathyroid tissue Ba2+-alginate capsules were developed that meet the requirements for long-term immunoisolated transplantation of (allogeneic and xenogeneic) cells and tissue fragments. Biocompatibility of the capsules was achieved by subjecting hi...

journal_title：Annals of the New York Academy of Sciences

authors： Zimmermann U,Thürmer F,Jork A,Weber M,Mimietz S,Hillgärtner M,Brunnenmeier F,Zimmermann H,Westphal I,Fuhr G,Nöth U,Haase A,Steinert A,Hendrich C

更新日期：2001-11-01 00:00:00

abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

journal_title：Annals of the New York Academy of Sciences

authors： Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

更新日期：2002-11-01 00:00:00

abstract：:In electrical impedance cardiography, Kubicek's formula is often used to measure stroke volume from thoracic impedance variations synchronously to heart activity. To calculate stroke volume from impedance variations, the so-called outflow problem should be adequately solved. This outflow problem refers to the joint ca...

journal_title：Annals of the New York Academy of Sciences

authors： Faes TJ,Raaijmakers E,Meijer JH,Goovaerts HG,Heethaar RM

更新日期：1999-04-20 00:00:00

abstract：:TT virus (TTV) is a recently described circular DNA virus of about 3.8 kb, which is related to the circoviridae viruses. It is commonly detected in healthy subjects and no association with any specific disease has been established. TTV was initially thought to be hepatotropic, but subsequent reports have shown that it...

journal_title：Annals of the New York Academy of Sciences

authors： Zhong S,Yeo W,Tang MW,Lin XR,Mo F,Ho WM,Hui P,Johnson PJ

更新日期：2001-09-01 00:00:00

abstract：:To investigate the role of poliovirus (PV) infection in the development of the post-polio syndrome (PPS), we studied the serum, spinal fluid, peripheral blood lymphocytes, and muscle from 47 patients with PPS. We found high titers of IgM PV antibodies (up to 1:250) in the serum of 6 patients, compared to very low tite...

journal_title：Annals of the New York Academy of Sciences

authors： Leon-Monzon ME,Dalakas MC

更新日期：1995-05-25 00:00:00

abstract：:Bioelectrical impedance spectroscopy (BIS) can provide estimates of body composition for both whole body (WB) and body segments (BS). In normal, healthy subjects, BS measurements may be expected to serve as surrogates for WB indices; however, very little is known about this correspondence in people suffering from acut...

journal_title：Annals of the New York Academy of Sciences

authors： Mazariegos M,Klassen P,Solomons NW,Fürst P

更新日期：2000-05-01 00:00:00

abstract：:Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

journal_title：Annals of the New York Academy of Sciences

authors： Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

更新日期：1986-01-01 00:00:00

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:5-Lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are two enzymes that are critical for the synthesis of eicosanoids, the inflammatory metabolites of arachidonic acid. Both 5-LOX and COX-2 are expressed in the brain, including in CNS neurons. The physiologic role of these proteins in neuronal functioning is not clea...

journal_title：Annals of the New York Academy of Sciences

authors： Manev H,Uz T,Manev R,Zhang Z

更新日期：2001-06-01 00:00:00

abstract：:A new autoimmune disease affecting the neuromuscular junction has been defined. Acquired neuromyotonia is associated with antibodies to voltage-gated potassium channels that act, at least in part, by reducing potassium channel function with resulting neuronal hyperactivity. This condition is quite frequently associate...

journal_title：Annals of the New York Academy of Sciences

authors： Vincent A,Jacobson L,Plested P,Polizzi A,Tang T,Riemersma S,Newland C,Ghorazian S,Farrar J,MacLennan C,Willcox N,Beeson D,Newsom-Davis J

更新日期：1998-05-13 00:00:00

abstract：:Acanthamoeba castellanii (A. castellanii) is a common soil- or water-borne protozoon that feeds on bacteria by phagocytosis. A. castellanii can grow between 4 and 32 degrees C and has to adapt quickly to chilling in order to survive. We have identified a Delta12-fatty acid desaturase as key to low temperature adaptati...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood JL

更新日期：2007-10-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a model mitochondrial inhibitor that causes selective neurodegeneration in brain. 3-NPA-induced neurodegeneration occurs via a secondary neurotoxicity, caused initially by ATP depletion and redox changes in the cell. It is known that the hippocampal degeneration caused by mitochondrial...

journal_title：Annals of the New York Academy of Sciences

authors： Przybyla-Zawislak BD,Thorn BT,Ali SF,Dennis RA,Amato A,Virmani A,Binienda ZK

更新日期：2005-08-01 00:00:00

abstract：:Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothel...

journal_title：Annals of the New York Academy of Sciences

authors： Shelton EL,Bader DM

更新日期：2012-10-01 00:00:00

abstract：:There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum. We have shown that ethanol in clinically relevant concentrations can in vitro induce TRH release from the septum by a mechanism involving neuronal swelling. Corticotropin-releasing hormone...

journal_title：Annals of the New York Academy of Sciences

authors： Kiss A,Adameová A,Kubovcáková L,Jamal B,Bacová Z,Zórad S,Tybitanclová K,Kvetnanský R,Strbák V

更新日期：2004-06-01 00:00:00

abstract：:The skeletal dysplasias or osteochondrodysplasias are a clinically and genetically heterogeneous group of disorders of bone and/or cartilage. They are characterized by abnormalities in pattering, linear growth, differentiation, and maintenance of the human skeleton. While they have been considered to be generalized di...

journal_title：Annals of the New York Academy of Sciences

authors： Rimoin DL,Cohn D,Krakow D,Wilcox W,Lachman RS,Alanay Y

更新日期：2007-11-01 00:00:00

abstract：:In preindustrial settings, biological, economic, and social mechanisms caused fertility to respond to feedback signals from population size variation in such a way as to steer populations toward equilibrium levels. It is unlikely that the relevant signal was population density; more plausibly the signal was economic w...

journal_title：Annals of the New York Academy of Sciences

authors： Lee R

更新日期：1994-02-18 00:00:00

abstract：:The presented paper describes a multi-disciplinary cooling selection approach applied to major gas turbine engine hot section components, including turbine nozzles, blades, discs, combustors and support structures, which maintain blade tip clearances. The paper demonstrates benefits of close interaction between partic...

journal_title：Annals of the New York Academy of Sciences

authors： Glezer B

更新日期：2001-05-01 00:00:00

abstract：:These findings demonstrate that calcium antagonists reverse renal vasoconstriction in a variety of settings. The ability of calcium antagonists to augment GFR of the vasoconstricted kidney is striking and has also been demonstrated in a number of in vivo settings. These observations and others raise the possibility th...

journal_title：Annals of the New York Academy of Sciences

authors： Loutzenhiser R,Epstein M

更新日期：1988-01-01 00:00:00

abstract：:Developing limb or differentiating neural and blood cells are traditional models used to study programmed cell death in mammals. The developing mouse dentition can also be an attractive model for studying apoptosis regulation. Apoptosis is most extant during early odontogenesis in mice. The embryonic tooth pattern is ...

journal_title：Annals of the New York Academy of Sciences

authors： Peterková R,Peterka M,Lesot H

更新日期：2003-12-01 00:00:00

abstract：:Locomotion control uses proprioceptive, visual, and vestibular signals. Previously, we analyzed the visual contribution with visual motion stimulation in roll while participants kept their heads in a normal upright orientation. In this study we applied the same visual disturbance in a head-upright and a nose-down cond...

journal_title：Annals of the New York Academy of Sciences

authors： Bardins S,Schneider E

更新日期：2009-05-01 00:00:00