Abstract:
:The endocannabinoid system, through the cannabinoid receptor CB1, is involved in the modulation of adaptive responses to environmental conditions. However, little is known about the role of the cannabinergic system, particularly CB1 receptor expression, in relation to the effects induced by xenoestrogens concerning the reproductive axis. Our results demonstrate that only 10(-8) mol/L of 17beta-estradiol was able to induce significantly higher levels of CB1A mRNA, while no effects were found after treatment with 4-nonylphenol (10(-8) or 10(-6) mol/L); moreover, mRNA expression titers of CB1B did not show any significant change. The estrogenic effects of treatments were evidenced by a dose-dependent induction of plasma hepatic vitellogenin titers. It can be concluded that low doses of estrogens, and possibly of xenoestrogens, may increase endocannabinoid signaling pathways.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Palermo FA,Angelini M,Cottone E,Virgili M,Franzoni MF,Mosconi G,Polzonetti-Magni AMdoi
10.1111/j.1749-6632.2009.04455.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
504-7eissn
0077-8923issn
1749-6632pii
NYAS04455journal_volume
1163pub_type
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