Origins of pathogenic anti-DNA idiotypes in the NZB X SWR model of lupus nephritis.

Abstract:

:The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction occurs in the NZB X NZW hybrids, but in this model, both the parental strains are abnormal and the nature of the gene products or their mechanism of action is unknown. In the NZB X SWR model, we have been able to identify a restricted subpopulation of nephritogenic anti-DNA antibody idiotypes that are encoded by genes of the normal SWR parents. Thus, these are one set of genes that determine the development of severe lupus nephritis in the F1 hybrids. In addition, another set of genes allows for the expansion of B cells that produce such pathogenic anti-DNA idiotypes in the F1 hybrids since such B-cell clones remain dormant in the normal SWR parents. The latter category of genes, presumably specifying defects in immunoregulation, are probably inherited from the NZB parents or may be the result of complementation of genes inherited from both parents. Further investigations with the NZB X SWR model will help us define the immunoregulatory defects in SLE that are specific for the T and B cells involved in pathogenic autoantibody production.

journal_name

Ann N Y Acad Sci

authors

Datta SK,Gavalchin J

doi

10.1111/j.1749-6632.1986.tb20855.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

47-58

eissn

0077-8923

issn

1749-6632

journal_volume

475

pub_type

杂志文章,评审
  • Synergistic effects of antiviral agents and humoral antibodies in experimental Herpesvirus hominis encephalitis.

    abstract::Experimental Herpesvirus hominis encephalitis in 3-week-old Swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-A), phosphonacetic acid (PAA), and humoral antibodies to H. hominis (HIG). Administration of ara-A, PAA, or HIG during the early phase of infection reduced the mortality rat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1977.tb21967.x

    authors: Cho CT,Feng KK

    更新日期:1977-03-04 00:00:00

  • Implications of tuberculosis in African wildlife and livestock.

    abstract::In most countries, tuberculosis caused by Mycobacterium bovis is mainly a disease of domestic cattle and can be controlled successfully by means of a test-and-slaughter program. Once the infection spills over into a wild animal species with maintenance host potential, conventional measures are no longer sufficient to ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04387.x

    authors: Michel AL

    更新日期:2002-10-01 00:00:00

  • Structure-function relation of the myosin motor in striated muscle.

    abstract::Force and shortening in striated muscle are driven by a structural working stroke in the globular portion of the myosin molecules-the myosin head-that cross-links the myosin-containing filaments and the actin-containing filaments. We use time-resolved X-ray diffraction in single fibers from frog skeletal muscle to lin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1341.021

    authors: Reconditi M,Linari M,Lucii L,Stewart A,Sun YB,Narayanan T,Irving T,Piazzesi G,Irving M,Lombardi V

    更新日期:2005-06-01 00:00:00

  • Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology.

    abstract::TP73, as a TP53 homologue, drew the attention of tumor biologists because it is rarely mutated in human cancers and can induce cell cycle arrest and apoptosis by activating genes also regulated by p53. However, TP73 harbors an additional promoter that produces a dominant negative p73 protein (deltaNp73) having the opp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1322.015

    authors: Rossi M,Sayan AE,Terrinoni A,Melino G,Knight RA

    更新日期:2004-12-01 00:00:00

  • Survey of small rodents and hematophagous flies in three sentinel farms in a Costa Rican vesicular stomatitis endemic region.

    abstract::A survey of rodents and hematophagous flies was conducted on three farms located in an area endemic for vesicular stomatitis to determine the species composition of each zoological group occurring in these areas. Eleven species of small rodents were collected and identified. Individuals from forty-nine species of hema...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05325.x

    authors: Jimenez AE,Vargas Herrera F,Salman M,Herrero MV

    更新日期:2000-01-01 00:00:00

  • Fermented wheat germ extract (avemar) inhibits adjuvant arthritis.

    abstract::Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethaso...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1423.037

    authors: Telekes A,Resetar A,Balint G,Blazso G,Falkay G,Lapis K,Raso E,Szende B,Ehrenfeld M,Shoenfeld Y,Hidvegi M

    更新日期:2007-09-01 00:00:00

  • Role of steroid hormone-regulated genes in implantation.

    abstract::The endometrium acquires the ability to implant the developing embryo within a specific time window, termed the "receptive phase." During this period, the endometrium undergoes pronounced structural and functional changes induced by the ovarian steroids, estrogen and progesterone, which prepare it to be receptive to i...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03792.x

    authors: Bagchi IC,Li Q,Cheon YP

    更新日期:2001-09-01 00:00:00

  • Epigenetic differences between sister chromatids?

    abstract::Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06505.x

    authors: Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

    更新日期:2012-08-01 00:00:00

  • West Nile fever in Israel 1999-2000: from geese to humans.

    abstract::West Nile virus (WNV) caused disease outbreaks in Israel in the 1950s and the late 1970s. In 1998 an outbreak of WNV in goose farms and evidence of infection in dead migratory birds were reported. Consequently, human diagnostic services for WNV were resumed, including virus isolation, serology, and RT-PCR. Risk factor...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb02691.x

    authors: Bin H,Grossman Z,Pokamunski S,Malkinson M,Weiss L,Duvdevani P,Banet C,Weisman Y,Annis E,Gandaku D,Yahalom V,Hindyieh M,Shulman L,Mendelson E

    更新日期:2001-12-01 00:00:00

  • Athletic amenorrhea: energy deficit or psychogenic challenge?

    abstract::Athletic women are at risk for developing ovulatory dysfunction, which presents variably as menstrual irregularity or absence. Initially characterized as an isolated disruption of hypothalamic gonadotropin-releasing hormone (GnRH) release, athletic amenorrhea, a form of hypogonadotropic hypogonadism, is invariably acc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05663.x

    authors: Pauli SA,Berga SL

    更新日期:2010-09-01 00:00:00

  • Antigenic profile, prevalence, and clinical significance of antiphospholipid antibodies in women referred for in vitro fertilization.

    abstract::The aim of this prospective study was to assess the prevalence of antiphospholipid antibodies (aPL) in women who had undergone in vitro fertilization (IVF) and the relationship between aPL and IVF outcome. A total of 101 infertile women with at least three unsuccessful IVF attempts were consecutively included in this ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1422.048

    authors: Sanmarco M,Bardin N,Camoin L,Beziane A,Dignat-George F,Gamerre M,Porcu G

    更新日期:2007-06-01 00:00:00

  • Effects of a splitter plate in the near wake of a divergent trailing edge.

    abstract::This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04555.x

    authors: Neau L,Pruvost J,Rodriguez O,Loc TP

    更新日期:2002-10-01 00:00:00

  • Metabolic syndrome: links to social stress and socioeconomic status.

    abstract::Socioeconomic stress associated with financial and psychosocial stress is widespread in society. A comprehensive body of research indicates that low socioeconomic status and social stress is associated with a broad spectrum of health risks. This paper reviews epidemiological evidence demonstrating the association betw...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06134.x

    authors: Tamashiro KL

    更新日期:2011-08-01 00:00:00

  • Membrane technologies applied to textile wastewater treatment.

    abstract::This paper describes the experimental results of a pilot-scale application of membrane technologies to textile wastewater advanced treatment, downstream of a biological activated sludge process, aimed at water reuse in textile technology processes. The chosen approach consisted of sand filtration as a pretreatment, a ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb05992.x

    authors: Marcucci M,Ciabatti I,Matteucci A,Vernaglione G

    更新日期:2003-03-01 00:00:00

  • The phenomenon of resveratrol: redefining the virtues of promiscuity.

    abstract::Cancer chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of carcinogenesis. With support provided by the National Cancer Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05849.x

    authors: Pezzuto JM

    更新日期:2011-01-01 00:00:00

  • Onset of odorant receptors.

    abstract::Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regardi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04366.x

    authors: Rodriguez-Gil DJ,Treloar HB,Miller A,Two A,Iwema C,Greer CA

    更新日期:2009-07-01 00:00:00

  • Ex vivo expansion and engraftment potential of cord blood-derived CD34+ cells in NOD/SCID mice.

    abstract::For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03569.x

    authors: Fibbe WE,Noort WA,Schipper F,Willemze R

    更新日期:2001-06-01 00:00:00

  • Uterine leiomyoma: a treatable condition.

    abstract::Many risk factors have been identified as having either a protective or a negative effect on the development of fibroids, but due to methodological issues and a lack of long-term studies, the exact effect of these factors is ambiguous. In similar dispute is the proper treatment of fibroids. Recent technological advanc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Moorehead ME,Conard CJ

    更新日期:2001-12-01 00:00:00

  • Mechanisms of immediate temperature compensation: experiments with brain synaptosomes from rat and ground squirrel.

    abstract::Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.005

    authors: Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

    更新日期:2005-06-01 00:00:00

  • Effect of a low salt diet on blood pressure and vasoactive hormones in the hereditary hypertriglyceridemic rat.

    abstract::In hereditary HTG rats, basal systolic blood pressure using tail-cuff sphygmomanometry was significantly higher (122.1 +/- 2.1 mm Hg; n = 16) than that in NTG animals (107.1 +/- 1.52; n = 16). A low salt diet did not influence blood pressure in NTG rats during the consecutive 4 weekly periods. However, in the second w...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb35719.x

    authors: Lichardus B,Seböková E,Jezová D,Mitková A,Zemánková A,Földes O,Vrána A,Klimes I

    更新日期:1993-06-14 00:00:00

  • Endotoxin-induced neutrophil adherence to endothelium: relationship to CD11b/CD18 and L-selectin expression and matrix disruption.

    abstract::The injury to vascular endothelium seen in severe bacterial infection may be mediated by neutrophil-derived enzymes. Neutrophil adhesion to endothelium, a prerequisite for this process, is mediated sequentially by the leukocyte adhesion molecules L-selectin and the beta 2 integrins, including CD11b/CD18. We have explo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb39799.x

    authors: Finn A,Strobel S,Levin M,Klein N

    更新日期:1994-05-28 00:00:00

  • Regulation of angiogenesis by controlling VEGF receptor.

    abstract::The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF. Immunohistochemical study showed that KDR exp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06315.x

    authors: Murota SI,Onodera M,Morita I

    更新日期:2000-05-01 00:00:00

  • Vascular dementia in Japan.

    abstract::Patients with vascular dementia are frequently encountered in Japan reaching nearly 50% of those with senile dementia, which is equal to or even slightly higher than patients with Alzheimer's disease. This contrasts with a much lower ratio of patients with vascular dementia in the United States. The majority of vascul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04795.x

    authors: Yanagihara T

    更新日期:2002-11-01 00:00:00

  • Immortal ethics.

    abstract::This article draws on ideas published in my "Intimations of Immortality" essay in Science (Vol. 288, No. 5463, p. 59, April 7, 2000) and my "Intimations of Immortality-The Ethics and Justice of Life Extending Therapies" in editor Michael Freeman's Current Legal Problems (Oxford University Press 2002: 65-97). This arti...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1297.098

    authors: Harris J

    更新日期:2004-06-01 00:00:00

  • New orbits for the n-body problem.

    abstract::In this paper, we consider minimizing the action functional as a method for numerically discovering periodic solutions to the n-body problem. With this method, we can find a large number of choreographies and other more general solutions. We show that most of the solutions found, including all but one of the choreogra...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1311.024

    authors: Vanderbei RJ

    更新日期:2004-05-01 00:00:00

  • On the true role of oxygen free radicals in the living state, aging, and degenerative disorders.

    abstract::Oxyradicals are generally considered harmful byproducts of oxidative metabolism, causing molecular damage in living systems. They are implicated in various processes such as mutagenesis, aging, and series of pathological events. Although all this may be justified, evidence is accumulating that it is an oversimplified ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05649.x

    authors: Nagy IZ

    更新日期:2001-04-01 00:00:00

  • Safety testing of needle free, jet injection devices to detect contamination with blood and other tissue fluids.

    abstract::Needle free jet injection guns have been used extensively in both veterinary and human health to deliver both vaccine and drugs, but in recent years, concerns have mounted for their potential to transmit blood borne disease agents among consecutive vaccinates. A Ped-O-Jet type jet injection device was used to deliver ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05361.x

    authors: Sweat JM,Abdy M,Weniger BG,Harrington R,Coyle B,Abuknesha RA,Gibbs EP

    更新日期:2000-01-01 00:00:00

  • Oxygen-sensitive potassium channels in chemoreceptor cell physiology: making a virtue of necessity.

    abstract::The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05037.x

    authors: Gonzalez C,Vaquero LM,López-López JR,Pérez-García MT

    更新日期:2009-10-01 00:00:00

  • Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids.

    abstract::Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05621.x

    authors: Kaipparettu BA,Ma Y,Wong LJ

    更新日期:2010-07-01 00:00:00

  • End-plate potentials in experimental autoimmune myasthenia gravis in rats.

    abstract::Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47694.x

    authors: Lambert EH,Lindstrom JM,Lennon VA

    更新日期:1976-01-01 00:00:00