1,111 patients with adrenal incidentalomas observed at a single endocrinological center: incidence of chromaffin tumors.

abstract：:Glucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon ge...

journal_title：Annals of the New York Academy of Sciences

authors： Ng SY,Lee LT,Chow BK

更新日期：2010-07-01 00:00:00

abstract：:The layered peptide array (LPA) is a recently developed technique designed to measure antibody levels in a multiplex, high-throughput manner. LPAs can assess antibody presence either in fluid samples or from tissues while maintaining the two-dimensional orientation of the life science platform. In this manuscript, we ...

journal_title：Annals of the New York Academy of Sciences

authors： Gannot G,Tangrea MA,Chuaqui RF,Gillespie JW,Emmert-Buck MR

更新日期：2007-03-01 00:00:00

abstract：:Six highly trained marathon runners developed myocardial infarction. One of the two cases of clinically diagnosed myocardial infarction was fatal, and there were four cases of angiographically-proven infarction. Two athletes had significant arterial disease of two major coronary arteries, a third had stenosis of the a...

journal_title：Annals of the New York Academy of Sciences

authors： Noakes T,Opie L,Beck W,McKechnie J,Benchimol A,Desser K

更新日期：1977-01-01 00:00:00

abstract：:The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing....

journal_title：Annals of the New York Academy of Sciences

authors： Atkinson NS,Brenner R,Bohm RA,Yu JY,Wilbur JL

更新日期：1998-11-16 00:00:00

abstract：:Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of (+/-)Huperzine A with those of (-)Huperzine A in ...

journal_title：Annals of the New York Academy of Sciences

authors： Hanin I,Tang XC,Kindel GL,Kozikowski AP

更新日期：1993-09-24 00:00:00

abstract：:The Ca2+-pump ATPase of human RBC membranes appears to be exquisitely sensitive to a variety of amphipathic molecules. The acidic protein calmodulin (CaM) activates the enzyme some three- to fivefold with an apparent Kd of approximately 1-5 nM. A variety of other amphipathic anions, such as acidic phospholipids, free ...

journal_title：Annals of the New York Academy of Sciences

authors： Vincenzi FF

更新日期：1982-01-01 00:00:00

abstract：:Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects are assessed in the rat during the first month of life, regarding both ...

journal_title：Annals of the New York Academy of Sciences

authors： Gomes-DA-Silva J,Silva MC,Tavares MA

更新日期：1998-05-01 00:00:00

abstract：:Taxonomic characterization of organisms in the genera Theileria and Babesia was originally based on observations of morphology and certain general phenotypic characteristics, which enabled many parasites to be unequivocally assigned to a particular genus. However, application of molecular genetic techniques, such as t...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp MT,Allsopp BA

更新日期：2006-10-01 00:00:00

abstract：:Exposure to phosphine (PH3 ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH3 poisoning is thought to target oxidative respiration, the exact mechanism of action remains largely unknown, resulting in limited treatment options. In our study, the effects ...

journal_title：Annals of the New York Academy of Sciences

authors： Tuet WY,Racine MC,Jennings L,Pierce SA,Tressler J,McCranor BJ,Wong B

更新日期：2020-11-01 00:00:00

abstract：:Cells derived from human trabecular bones have been shown to have multipotential differentiation ability along osteogenic, chondrogenic, and adipogenic lineages. In this study, we have derived two clonal sublines of human trabecular bone cells by means of stable transduction with human papilloma virus E6/E7 genes. Our...

journal_title：Annals of the New York Academy of Sciences

authors： Osyczka AM,Nöth U,Danielson KG,Tuan RS

更新日期：2002-06-01 00:00:00

abstract：:An apparently macromolecular factor is isolated from aqueous skin extracts which inhibits DNA synthesis in vivo and in vitro with high efficacy (ID50 in vivo 0.2 pmol/g, in vitro 0.2 pM) and in a highly specific manner showing a point of attack in the late G1-phase of the cell cycle (epidermal G1-chalone). Preliminary...

journal_title：Annals of the New York Academy of Sciences

authors： Richter KH,Clauss M,Höfle W,Schnapke R,Marks F

更新日期：1988-01-01 00:00:00

abstract：:Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Stirban A,Negrean M,Götting C,Uribarri J,Gawlowski T,Stratmann B,Kleesiek K,Koschinsky T,Vlassara H,Tschoepe D

更新日期：2008-04-01 00:00:00

abstract：:This study measured on-road driving behavior in subjects with bilateral vestibular loss (BVL). Data included point-of-regard (what the driver is looking at and attending to), gaze stability (the performance of the vestibulo-ocular reflex), and head movement, during complex maneuvers such as changing lanes, cornering, ...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Moore ST,Black RA,Jolly N,Curthoys IS

更新日期：2009-05-01 00:00:00

abstract：:Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

journal_title：Annals of the New York Academy of Sciences

authors： Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T(reg)) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of T(reg) function, has been the discovery th...

journal_title：Annals of the New York Academy of Sciences

authors： Pino-Lagos K,Benson MJ,Noelle RJ

更新日期：2008-11-01 00:00:00

abstract：:Three patients with the clinical diagnosis of Wallenberg's syndrome caused by acute unilateral ischemic infarctions, which included the vestibular nucleus in the medullary brain stem and afferent vestibular pathways, were examined by positron emission tomography (PET) during caloric vestibular stimulation. They all ha...

journal_title：Annals of the New York Academy of Sciences

authors： Dieterich M,Bense S,Stephan T,Brandt T,Schwaiger M,Bartenstein P

更新日期：2005-04-01 00:00:00

abstract：:Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cong Y,Liu C,Weaver CT,Elson CO

更新日期：2004-12-01 00:00:00

abstract：:Previous studies showed that exposure of experimental animals to immobilization stress increases colonic motility and that these effects are mediated by release of corticotropin-releasing factor (CRF), Studies from our laboratory showed that 30-min immobilization stress of rats caused several not previously described ...

journal_title：Annals of the New York Academy of Sciences

authors： Pothoulakis C,Castagliuolo I,Leeman SE

更新日期：1998-05-01 00:00:00

abstract：:For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the in vitro combination of elements judged necessary for in vivo impla...

journal_title：Annals of the New York Academy of Sciences

authors： Arakelian L,Kanai N,Dua K,Durand M,Cattan P,Ohki T

更新日期：2018-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stress than do normal c...

journal_title：Annals of the New York Academy of Sciences

authors： Suh DH,Kim MK,Kim HS,Chung HH,Song YS

更新日期：2012-10-01 00:00:00

abstract：:In the current study, we examined the effects of minocycline on the osteopenia of ovariectomized (OVX) aged rats using the marrow ablation model. This injury induces rapid bone formation followed by bone resorption in the marrow cavity. Old female rats were randomly divided into five groups: sham, OVX, OVX + minocycli...

journal_title：Annals of the New York Academy of Sciences

authors： Williams S,Barnes J,Wakisaka A,Ogasa H,Liang CT

更新日期：1999-06-30 00:00:00

abstract：:The mechanism of action of tocopherol transfer protein (TTP) and its role in the intracellular processing of vitamin E were investigated using confocal fluorescence microscopy. The results from this work suggest that TTP functions by transporting vitamin E from endocytic organelles to other locations in the cell. ...

journal_title：Annals of the New York Academy of Sciences

authors： Qian J,Wilson K,Nava P,Morley S,Atkinson J,Manor D

更新日期：2004-12-01 00:00:00

abstract：:We previously showed that pituitary adenylate cyclase-activating polypeptide (PACAP) potently stimulates insulin secretion in vivo in mice without altering glucose disposal. Such a combination of results would be explained if epinephrine released by PACAP counteracts the action of insulin and, therefore, that the gluc...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B,Filipsson K

更新日期：2000-01-01 00:00:00

abstract：:The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction ...

journal_title：Annals of the New York Academy of Sciences

authors： Datta SK,Gavalchin J

更新日期：1986-01-01 00:00:00

abstract：:Nicergoline (NE)--a cerebral vasodilator with nicotinic acid esterified in its molecule--and Antagonic-Stress (AS) composition--a neurometabolic nootropic, also containing nicotinic acid but with fast and prolonged release--were evaluated in senile dementia of Alzheimer's type (SDAT), mild to moderate intensity (DSM-I...

journal_title：Annals of the New York Academy of Sciences

authors： Schneider F,Popa R,Mihalas G,Stefanigă P,Mihalas IG,Măties R,Mateescu R

更新日期：1994-06-30 00:00:00

abstract：:Since the late sixties, several new antifungal drugs have become available. Initially, they were all intended for topical use, and, consequently, animal and human pharmacology always primarily aimed at confirming therapeutic efficacy. With the new tendency for the development of orally active antifungal drugs, human a...

journal_title：Annals of the New York Academy of Sciences

authors： Cauwenbergh G,Van Cutsem J

更新日期：1988-01-01 00:00:00

abstract：:In spite of increasing incidence of esophageal adenocarcinoma in the last few decades, esophageal squamous cell carcinoma (SCC) still remains the dominant subtype of esophageal cancer worldwide. Apart from conventional SCC, some rare unconventional tumors of esophageal squamous mucosa are also well known. This study p...

journal_title：Annals of the New York Academy of Sciences

authors： Tripathi M,Swanson PE

更新日期：2016-10-01 00:00:00

abstract：:The xynA gene encoding a major xylanase of Clostridium stercorarium F-9 was sequenced. The structural gene consists of an open reading frame of 1533 bp encoding a protein of 511 amino acids with an M(r) of 56,519. XynA consists of a catalytic domain belonging to family G at the NH2-terminus and two direct repeats of a...

journal_title：Annals of the New York Academy of Sciences

authors： Sakka K,Takada G,Karita S,Ohmiya K

更新日期：1996-05-15 00:00:00

abstract：:Advanced glycation end products (AGEs) are the result of a nonenzymatic reaction of reducing sugars with primary amino groups of proteins (Maillard reaction). They accumulate in various tissues in the course of aging. Because AGEs induce protein cross-links and oxidative stress (radicals) within cells and tissues, the...

journal_title：Annals of the New York Academy of Sciences

authors： Simm A,Bartling B,Silber RE

更新日期：2004-06-01 00:00:00

abstract：:It is believed that HDL exerts its anti-atherogenic effects through the process of delivering cholesterol from peripheral tissues back to the liver for removal from the body (i.e., reverse cholesterol transport). The metabolic life cycle of HDL lipid and apolipoproteins during reverse cholesterol transport involves bo...

journal_title：Annals of the New York Academy of Sciences

authors： Silver DL,Jiang XC,Arai T,Bruce C,Tall AR

更新日期：2000-05-01 00:00:00