Acquired enamel pellicle and its potential role in oral diagnostics.

Abstract:

:The acquired enamel pellicle (AEP) is a protein film with unique composition and properties, which is formed by the selective adsorption of a variety of oral fluid-derived proteins onto tooth enamel surfaces. Since events leading to caries and periodontal disease occur in close proximity to the tooth surface, pellicle constituents are likely to contain biomarkers valuable for diagnostic applications. Despite the importance of this oral structure, progress in understanding its formation and composition has been slow because of difficulties in efficient pellicle collection methods and limitations of biochemical techniques for the characterization of microgram amounts of proteins/peptides. Recent developments in both pellicle collection methods and nanoscale sensing technologies have brought the exploitation of pellicle analysis into the realm of point-of-care oral diagnostics.

journal_name

Ann N Y Acad Sci

authors

Siqueira WL,Helmerhorst EJ,Zhang W,Salih E,Oppenheim FG

doi

10.1196/annals.1384.023

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

504-9

eissn

0077-8923

issn

1749-6632

pii

1098/1/504

journal_volume

1098

pub_type

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