Bcl-2 and p53: role in dopamine-induced apoptosis and differentiation.

Abstract:

:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chick sympathetic neurons. Another gene that plays a role in apoptosis and differentiation of neurons, oligodendrocytes and PC12 cells is p53. It is also known that DNA damage increases p53 levels, triggering repair or apoptosis in response to moderate or severe damage, respectively. NMB cells express active and inducible forms of p53, thus being particularly suitable to analyze the role of this gene in dopamine-induced apoptosis and differentiation. The main observation of this work is that low concentrations of dopamine induce differentiation while high concentrations induce apoptosis, and that concentrations of dopamine that induce apoptosis increased p53 levels. There peak increase in p53 was within 3-6 h, before cell death. Thus, treatment with a high dopamine concentration may result in oxidation products and/or free radicals that heavily damage DNA, thus increasing p53 levels and initiating a cascade of events leading to apoptosis. Lower concentrations of dopamine apparently have a milder damaging effect on the DNA and induce growth arrest and differentiation. In various systems Bcl-2 inhibits cell death, being apoptotic or necrotic. Bcl-2, and other members of the family, such as Bax, are located downstream to p53 in the apoptotic pathway, and they contain negative or positive p53 response elements. Bcl-2 also protects cells by acting as antioxidant. Neuronal differentiation may be accompanied with an increase in Bcl-2, though it was suggested that the role of Bcl-2 in differentiation is less critical than in apoptosis. Herein, Bcl-2 was found to inhibit dopamine neurotoxicity. Whether the expression of Bcl-2 is regulated by different dopamine concentrations, or by dibutyryl-cAMP and DMSO, remains to be determined.

journal_name

Ann N Y Acad Sci

authors

Porat S,Simantov R

doi

10.1111/j.1749-6632.1999.tb07858.x

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

372-5

eissn

0077-8923

issn

1749-6632

journal_volume

893

pub_type

杂志文章
  • MHC class I chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families.

    abstract::Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by autoimmune destruction of pancreatic beta cells. Genetic and environmental factors contribute in this disease. There is evidence that MHC class I chain-related gene (MIC-A) plays a role in the susceptibility to this and other autoimmune diseases...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02993.x

    authors: Zake LN,Ghaderi M,Park YS,Babu S,Eisenbarth G,Sanjeevi CB

    更新日期:2002-04-01 00:00:00

  • Cellular resistance to arbovirus infection.

    abstract::When an arbovirus enters an arthropod in an infected blood meal, several mechanisms may interact to affect its life cycle and ultimate transmissibility. Intrinsic absolute failure in the establishment of infection must be contrasted with infection that is successfully established but is variably modulated in its viral...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb35101.x

    authors: Murphy FA

    更新日期:1975-01-01 00:00:00

  • Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus.

    abstract::Mice with experimental neuropsychiatric lupus (NPSLE), induced by anti-ribosomal-P antibodies, developed depression-like behavior and a diminished sense of smell. Manganese-enhanced MRI (MEMRI) allows in vivo mapping of functional neuronal connections in the brain, including the olfactory tract. The aim of this study ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05302.x

    authors: Kivity S,Tsarfaty G,Agmon-Levin N,Blank M,Manor D,Konen E,Chapman J,Reichlin M,Wasson C,Shoenfeld Y,Kushnir T

    更新日期:2010-04-01 00:00:00

  • Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians.

    abstract::Glucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon ge...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2010.05505.x

    authors: Ng SY,Lee LT,Chow BK

    更新日期:2010-07-01 00:00:00

  • The effect of fasting and vitamin E on insulin action in obese type 2 diabetes mellitus.

    abstract::The influence of either short-term fasting or vitamin E administration on insulin action was studied in two groups of obese Type 2 diabetic patients. Twelve patients underwent 7 days of fasting (group A), whereas 600 mg of vitamin E was administered daily during 3 months in 9 diabetic patients (group B). Insulin actio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb51870.x

    authors: Skrha J,Sindelka G,Hilgertová J

    更新日期:1997-09-20 00:00:00

  • Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor.

    abstract::The involvement of the c-Myc transcription factor in neoplastic transformation is well documented. However, which of its numerous target genes are crucial for tumorigenesis remains a frequently contested issue. We have recently established a non-transgenic murine model for B-cell lymphoma based on neoplastic conversio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1339.047

    authors: Yu D,Cozma D,Park A,Thomas-Tikhonenko A

    更新日期:2005-11-01 00:00:00

  • Critically important antibiotics: criteria and approaches for measuring and reducing their use in food animal agriculture.

    abstract::Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all ap...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14058

    authors: Scott HM,Acuff G,Bergeron G,Bourassa MW,Gill J,Graham DW,Kahn LH,Morley PS,Salois MJ,Simjee S,Singer RS,Smith TC,Storrs C,Wittum TE

    更新日期:2019-04-01 00:00:00

  • Calcium entry, calcium redistribution, and exocytosis.

    abstract::At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca(2+) concentration, [Ca(2+)](c), depend on at least three efficient regulatory mechanisms: (1) the plasmalemmal Ca(2+) channels; (2) the endoplasmic reticulum (ER); and (3) the mitochondria. High-voltage activated Ca(2+) channels of the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04444.x

    authors: Cuchillo-Ibanez I,Albillos A,Aldea M,Arroyo G,Fuentealba J,Garcia AG

    更新日期:2002-10-01 00:00:00

  • Cell-free synthesis of watermelon glyoxysomal malate dehydrogenase: a comparison with the mitochondrial isoenzyme.

    abstract::Cotyledons of dark-grown watermelon seedlings contain during the first period of germination, 4 and later 5 MDH isoenzymes. Whereas isoenzymes I, II, and IV belong to the cytosol, isoenzyme III is confined to the mitochondria (mMDH) and isoenzyme V to the glyoxysomes (gMDH). The organelle-bound MDHs were purified to h...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb21427.x

    authors: Hock B,Gietl C

    更新日期:1982-01-01 00:00:00

  • Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E.

    abstract::Accelerated atherosclerosis occurs in patients with type III hyperlipoproteinemia and familial hypercholesterolemia. These genetic disorders focus attention on specific types of lipoproteins as being responsible for the development of accelerated coronary artery heart disease. The accumulation of chylomicron remnants ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb42274.x

    authors: Weisgraber KH,Innerarity TL,Rall SC Jr,Mahley RW

    更新日期:1990-01-01 00:00:00

  • New trends in astrodynamics and applications: optimal trajectories for space guidance.

    abstract::This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.002

    authors: Azimov D,Bishop R

    更新日期:2005-12-01 00:00:00

  • The role of arginine vasopressin on peripheral cardiac parasympathetic nerve function in the rat.

    abstract::In rats, arginine vasopressin augments bradycardia associated with baroreflex activation. We investigated whether modulation of peripheral cardiac parasympathetic nerve function by AVP may play a role in this effect. To accomplish this we utilized an in vivo model with which we previously demonstrated both adrenergic ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb55560.x

    authors: Pardini BJ,Lund DD,Schmid PG

    更新日期:1993-07-22 00:00:00

  • Inactive form of carbonic anhydrase I in erythrocytes from primary aldosteronism.

    abstract::An inactive form of erythrocyte CA I was found in patients with primary aldosteronism. The levels of CA I in the patients were within the normal range: however, the specific esterase activity of CA I from three patients was in the range of 0.12-0.26 u/mg CA I (normal control: 0.66 +/- 0.1 u/mg CA I). In one subject, w...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1984.tb12353.x

    authors: Kondo T,Taniguchi N,Hirano T,Kawakami Y

    更新日期:1984-01-01 00:00:00

  • The estimation of probable maximum precipitation: the case of Catalonia.

    abstract::A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1446.003

    authors: Casas MC,Rodríguez R,Nieto R,Redaño A

    更新日期:2008-12-01 00:00:00

  • The design of orally active iron chelators.

    abstract::It is now generally accepted that it is not possible to design iron(III)-selective hexadentate chelators with high oral bioavailability. In order to achieve suitable levels of oral activity for the treatment of systemic iron overload either tridentate or bidentate molecules need to be investigated. There are a number ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1345.017

    authors: Hider RC,Zhou T

    更新日期:2005-01-01 00:00:00

  • Vitamin E in preeclampsia.

    abstract::Preeclampsia is the disorder of pregnancy with the highest rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by oxidative stress and activation of the vascular endothelium that may originate from placental release of lipid peroxidation products, cytokines, and micropart...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1331.024

    authors: Poston L,Raijmakers M,Kelly F

    更新日期:2004-12-01 00:00:00

  • Neurophysiology and new techniques to assess esophageal sensory function: an update.

    abstract::This review aims to discuss the neurophysiology of the esophagus and new methods to assess esophageal nociception. Pain and other symptoms can be caused by diseases in the mucosa or muscular or sphincter dysfunction, together with abnormal pain processing, either in the peripheral or central nervous systems. Therefore...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13175

    authors: Brock C,McCallum RW,Gyawali CP,Farmer AD,Frøkjaer JB,McMahon BP,Drewes AM

    更新日期:2016-09-01 00:00:00

  • Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players.

    abstract::Obesity and Type 2 diabetes are now major public health issues in developed nations and have reached epidemic proportions in many developing nations, as well as disadvantaged groups in developed countries, e.g., Mexican-Americans, African-Americans, and Australian Aborigines. These groups all show hyperinsulinemia and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07783.x

    authors: Zimmet P,Boyko EJ,Collier GR,de Courten M

    更新日期:1999-11-18 00:00:00

  • Statistical learning of speech, not music, in congenital amusia.

    abstract::The acquisition of both speech and music uses general principles: learners extract statistical regularities present in the environment. Yet, individuals who suffer from congenital amusia (commonly called tone-deafness) have experienced lifelong difficulties in acquiring basic musical skills, while their language abili...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06429.x

    authors: Peretz I,Saffran J,Schön D,Gosselin N

    更新日期:2012-04-01 00:00:00

  • Proteomic method for the quantification of methionine sulfoxide.

    abstract::Glycoxidation and lipoxidation reactions contribute to the chemical modification of proteins during the Maillard reaction. Reactive oxygen species, produced during the oxidation of sugars and lipids in these processes, irreversibly oxidize proteins. Methionine is particularly susceptible to oxidation, yielding the oxi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1333.035

    authors: Brock JW,Cotham WC,Ames JM,Thorpe SR,Baynes JW

    更新日期:2005-06-01 00:00:00

  • Flexible neural representations of value in the primate brain.

    abstract::The amygdala and orbitofrontal cortex (OFC) are often thought of as components of a neural circuit that assigns affective significance--or value--to sensory stimuli so as to anticipate future events and adjust behavioral and physiological responses. Much recent work has been aimed at understanding the distinct contrib...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1401.034

    authors: Salzman CD,Paton JJ,Belova MA,Morrison SE

    更新日期:2007-12-01 00:00:00

  • Interactions of vitamin C with lead and mercury.

    abstract::Ascorbic acid has been found to interact with several elements in such a manner as to render them less available for animals. This property of the vitamin has a negative effect on the animals fed a copper-deficient diet, but a positive effect on those fed toxic levels of copper, selenium, vanadium, and cobalt. The eff...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb21344.x

    authors: Hill CH

    更新日期:1980-01-01 00:00:00

  • Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.

    abstract::This study investigates the effects of agmatine on naloxone-precipitated withdrawal syndrome in morphine-dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1304.016

    authors: Aricioglu F,Ercil E,Dulger G

    更新日期:2003-12-01 00:00:00

  • Emission of polycyclic aromatic hydrocarbons from indoor straw burning and emission inventory updating in China.

    abstract::The emission factors for indoor straw combustion are a major data gap for estimating the polycyclic aromatic hydrocarbon (PAH) emissions in China. The emission factors for open-fire straw burning were borrowed from our previous study and a rough estimate was developed. As one of the most important emission sources in ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1454.006

    authors: Zhang Y,Dou H,Chang B,Wei Z,Qiu W,Liu S,Liu W,Tao S

    更新日期:2008-10-01 00:00:00

  • Effect of microgravity and magnetic field on the metallic and crystalline structure of magnetostrictive SmFe2 synthesized by unidirectional solidification.

    abstract::The Sm-2Fe molten alloy with 1:2 molar ratio was unidirectionally solidified in both microgravity and normal gravity in concurrence with a magnetic flux (0-0.12 T). The compound SmFe2 was produced by the unidirectional solidification in microgravity with a magnetic flux of 0T and exhibited a lamellar microstructure. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1362.004

    authors: Okutani T,Nagai H,Mamiya M,Shibuya M,Castillo M

    更新日期:2006-09-01 00:00:00

  • Impact of vertigo and spatial disorientation on concurrent cognitive tasks.

    abstract::Disorientation may draw attention from other activities and its impact on cognition may cause pilot error and problems of concentration in dizzy patients. Tasks used to study the impact of disorientation include number processing, intelligence scales and Brookes matrices (reproduction of 2xD patterns of numbers vs. no...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03744.x

    authors: Gresty MA,Golding JF

    更新日期:2009-05-01 00:00:00

  • Nutrient supplementation during the first 1000 days and growth of infants born to pregnant adolescents.

    abstract::Few studies have evaluated the impact of nutritional supplementation among pregnant adolescents. We examined the effects of the Rang Din Nutrition Study (RDNS) interventions on children born to mothers <20 years of age. The RDNS was a cluster-randomized effectiveness trial with four arms: (1) women and children both r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/nyas.14191

    authors: Dewey KG,Matias SL,Mridha MK,Arnold CD

    更新日期:2020-05-01 00:00:00

  • The music instinct: the evolutionary basis of musicality.

    abstract::Why does music pervade our lives and those of all known human beings living today and in the recent past? Why do we feel compelled to engage in musical activity, or at least simply enjoy listening to music even if we choose not to actively participate? I argue that this is because musicality--communication using varia...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04590.x

    authors: Mithen S

    更新日期:2009-07-01 00:00:00

  • T-cell receptor V-region usage and antigen specificity. The cytochrome c model system.

    abstract::Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1995.tb44477.x

    authors: Davis MM,McHeyzer-Williams M,Chien YH

    更新日期:1995-07-07 00:00:00

  • Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions.

    abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. The 5-year survival rate is still relatively low due to few symptoms presenting with the early disease, diagnosis at middle to late stage, and high risk of recurrence after therapy. Novel protein biomarkers for early detec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13863

    authors: Wang M,Smith JS,Wei WQ

    更新日期:2018-12-01 00:00:00