Abstract:
:The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands from males of Boophilus microplus were PCR amplified, and the expressed sequence tags (EST) of random clones were mass sequenced. So far, more than 1,344 EST have been generated for these tissues, with approximately 30% novelty, depending on the the tissue studied. To date approximately 760 nucleotide sequences from B. microplus are deposited in the NCBI database. Mass sequencing of partial cDNAs of parasite genes can build up this scant database and rapidly generate a large quantity of useful information about potential targets for immunobiological or chemical control.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Santos IK,Valenzuela JG,Ribeiro JM,de Castro M,Costa JN,Costa AM,da Silva ER,Neto OB,Rocha C,Daffre S,Ferreira BR,da Silva JS,Szabó MP,Bechara GHdoi
10.1196/annals.1307.037subject
Has Abstractpub_date
2004-10-01 00:00:00pages
242-6eissn
0077-8923issn
1749-6632pii
1026/1/242journal_volume
1026pub_type
杂志文章abstract::Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders that cause individuals to be prone to a variety of clinical manifestations, such as infections, autoimmunity, and malignancies. Early diagnosis and adequate treatment of these disorders can reduce morbidity and mortality and prov...
journal_title:Annals of the New York Academy of Sciences
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