The policy context for child and adolescent mental health services: implications for systems reform and basic science development.

abstract：:Human immunodeficiency virus type 1 (HIV-1)-positive patients in the late phase of infection develop AIDS dementia complex, an array of neurological complications that include extrapyramidal symptoms, cognitive impairments, and psychiatric disturbances. Brains of these patients exhibit brain injury. The HIV-1 envelope...

journal_title：Annals of the New York Academy of Sciences

authors： Bachis A,Mocchetti I

更新日期：2005-08-01 00:00:00

abstract：:The layered peptide array (LPA) is a recently developed technique designed to measure antibody levels in a multiplex, high-throughput manner. LPAs can assess antibody presence either in fluid samples or from tissues while maintaining the two-dimensional orientation of the life science platform. In this manuscript, we ...

journal_title：Annals of the New York Academy of Sciences

authors： Gannot G,Tangrea MA,Chuaqui RF,Gillespie JW,Emmert-Buck MR

更新日期：2007-03-01 00:00:00

abstract：:Toluene, a volatile hydrocarbon found in a variety of chemical compounds, is misused and abused by inhalation for its euphorigenic effects. Toluene's reinforcing properties may share a common characteristic with other drugs of abuse, namely, activation of the mesolimbic dopamine system. Prior studies in our laboratory...

journal_title：Annals of the New York Academy of Sciences

authors： Riegel AC,Ali SF,Torinese S,French ED

更新日期：2004-10-01 00:00:00

abstract：:Children exposed in utero to cocaine are at risk for long-term neurobehavioral damage not just because of the drug itself, but also because of clustering of other health determinants, including low socioeconomic status, low maternal education, and maternal addiction, to mention a few. One methodologic approach to sepa...

journal_title：Annals of the New York Academy of Sciences

authors： Koren G,Nulman I,Rovet J,Greenbaum R,Loebstein M,Einarson T

更新日期：1998-06-01 00:00:00

abstract：:The Balb/c mice were infected with Coxiella burnetii and samples of blood and major organs from the infected mice were collected on days 1 to 14 after infection. The DNAs extracted from the samples were detected by a developed real-time quantitative PCR specific for C. burnetii and high loads of C. burnetii were found...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang J,Wen B,Chen M,Zhang J,Niu D

更新日期：2005-12-01 00:00:00

abstract：:Left ventricular (LV) wall motion abnormalities reflect regional nonuniform contraction which may be arrhythmogenic. We studied sarcomere mechanics and force development (F) in uniform and nonuniform trabeculae using a model in which half of the muscle can be rendered weak by exposure to low [Ca2+]o. Stretch allowed t...

journal_title：Annals of the New York Academy of Sciences

authors： ter Keurs HE,Diao N,Deis NP

更新日期：2010-02-01 00:00:00

abstract：:Our molecular studies have revealed the existence of a large number of different subunits or subtypes for the NMDA and metabotropic glutamate receptors. The individual receptors show functional variabilities and distinct expression patterns in the CNS. The NMDA receptors belong to the ligand-gated ion channel family a...

journal_title：Annals of the New York Academy of Sciences

authors： Masu M,Nakajima Y,Moriyoshi K,Ishii T,Akazawa C,Nakanashi S

更新日期：1993-12-20 00:00:00

abstract：:Dysregulation of apoptosis is associated with the pathogenesis of organ-specific autoimmune diseases, through altered target organ susceptibility. Apoptosis signaling pathways can be initiated through activation of death receptors such as Fas. A comparative analysis of the expression of Fas and FasL, the antiapoptotic...

journal_title：Annals of the New York Academy of Sciences

authors： Salmaso C,Bagnasco M,Pesce G,Montagna P,Brizzolara R,Altrinetti V,Richiusa P,Galluzzo A,Giordano C

更新日期：2002-06-01 00:00:00

abstract：:Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses af...

journal_title：Annals of the New York Academy of Sciences

authors： Cantley LC,Whitman M,Chahwala S,Fleischman L,Kaplan DR,Schaffhausen BS,Roberts TM

更新日期：1986-01-01 00:00:00

abstract：:The following on molecular aspects of esophageal development contains commentaries on esophageal striated myogenesis and transdifferentiation; conversion from columnar into stratified squamous epithelium in the mouse esophagus; the roles for BMP signaling in the developing esophagus and forestomach; and evidence of a ...

journal_title：Annals of the New York Academy of Sciences

authors： Rishniw M,Rodriguez P,Que J,Burke ZD,Tosh D,Chen H,Chen X

更新日期：2011-09-01 00:00:00

abstract：:The present study was designed to immunochemically identify a coronin-like protein in Babesia bovis, B. bigemina, B. divergens, and B. canis. A 2-kbp cDNA insert of B. bovis carried by plasmid BvN9 was sequenced by the dideoxichain-termination method on both strands. The cDNA insert contained a 1719-bp long open readi...

journal_title：Annals of the New York Academy of Sciences

authors： Figueroa JV,Precigout E,Carcy B,Gorenflot A

更新日期：2004-10-01 00:00:00

abstract：:Mounting evidence indicates increased susceptibility to cell death and increased oxidative damage as common features in neurons from sporadic Alzheimer's disease (AD) patients but also from familial AD (FAD) cases. Autosomal dominant forms of FAD are caused by mutations of the amyloid precursor protein (APP) gene and ...

journal_title：Annals of the New York Academy of Sciences

authors： Eckert A,Marques CA,Keil U,Schüssel K,Müller WE

更新日期：2003-12-01 00:00:00

abstract：:Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess ...

journal_title：Annals of the New York Academy of Sciences

authors： Kletsas D,Pratsinis H,Gioni V,Pilichos K,Yiacoumettis AM,Tsagarakis S

更新日期：2007-04-01 00:00:00

abstract：:The same retinal image motion can be produced by a variety of combinations of eye and target motion. In natural conditions, extraretinal information disambiguates retinal information for motion perception. By controlling the timing of visual motion with respect to saccades, it was possible to appraise the roles for mo...

journal_title：Annals of the New York Academy of Sciences

authors： Lee C,Lee J

更新日期：2005-04-01 00:00:00

abstract：:A major challenge in systems biology is to evaluate the feasibility of a biological research project prior to its realization. Since experiments are animals-, cost- and time-consuming, approaches allowing researchers to discriminate alternative hypotheses with a minimal set of experiments are highly desirable. Given a...

journal_title：Annals of the New York Academy of Sciences

authors： Maiwald T,Kreutz C,Pfeifer AC,Bohl S,Klingmüller U,Timmer J

更新日期：2007-12-01 00:00:00

abstract：:During their development, mononuclear phagocytes express a changing profile of proteinases that may participate in the degradation of elastin and other extracellular matrix components. Neutrophil elastase is produced and stored in azurophil-like granules in immature mononuclear phagocytes. Monocytes contain small amou...

journal_title：Annals of the New York Academy of Sciences

authors： Shapiro SD,Campbell EJ,Welgus HG,Senior RM

更新日期：1991-01-01 00:00:00

abstract：:The Guillain Barré syndromes (GBS) are the world's leading cause of acute autoimmune neuromuscular paralysis. Understanding the pathophysiological events of GBS, and improving immunotherapies are fundamental to improving the clinical outcome. Recent research into GBS and the Miller Fisher syndrome (MFS) variant has fo...

journal_title：Annals of the New York Academy of Sciences

authors： Willison HJ,Plomp JJ

更新日期：2008-01-01 00:00:00

abstract：:The paper describes an algorithm and computational system used to estimate the spatial chaos of magnetic resonance images of patients with gastric cancer and the quantum chaos of mechanoemission in blood. ...

journal_title：Annals of the New York Academy of Sciences

authors： Orel VE,Romanov AV,Dzyatkovskaya NN,Mel'Nik YI

更新日期：2002-10-01 00:00:00

abstract：:A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-K...

journal_title：Annals of the New York Academy of Sciences

authors： Maruyama N,Ishigami A,Kuramoto M,Handa S,Kubo S,Imasawa T,Seyama K,Shimosawa T,Kasahara Y

更新日期：2004-06-01 00:00:00

abstract：:A generation of research in cognitive psychology has given rise to many tasks that tap at various aspects of attention. It is now widely agreed that attention is not a single thing and that its measurement needs a strategy to study each of its various aspects. While there is no widely agreed taxonomy of attentional op...

journal_title：Annals of the New York Academy of Sciences

authors： Posner MI

更新日期：2008-01-01 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

journal_title：Annals of the New York Academy of Sciences

authors： Lambert EH,Lindstrom JM,Lennon VA

更新日期：1976-01-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types. It is well established that some of the catabolic effects of the proinflammatory cytokines interleukin-1beta (IL-1beta) and ...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze-Tanzil G,Mobasheri A,Sendzik J,John T,Shakibaei M

更新日期：2004-12-01 00:00:00

abstract：:Kinetics of extracellular RNA accumulation in culture medium and at the cell surface along with their composition and distribution among cell-free and cell-surface-bound fractions were investigated in mycoplasma-contaminated and mycoplasma-free HeLa cells. It was shown that the mycoplasma infection influenced the conc...

journal_title：Annals of the New York Academy of Sciences

authors： Morozkin ES,Rykova EY,Vlassov VV,Laktionov PP

更新日期：2006-09-01 00:00:00

abstract：:Smooth septate junctions (sSJs) are cell-cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ-sp...

journal_title：Annals of the New York Academy of Sciences

authors： Furuse M,Izumi Y

更新日期：2017-06-01 00:00:00

abstract：:In this chapter, we will review how signal transduction pathways have been assembled in the past, bringing us to our present understanding of this area of research. The methods employed have relied heavily upon the genetics of yeast, worms, flies, mice, and humans. The use of second site suppressors and epistasis has ...

journal_title：Annals of the New York Academy of Sciences

authors： Levine AJ,Hu W,Feng Z,Gil G

更新日期：2007-12-01 00:00:00

abstract：:Tissue engineering (TE) approaches are being widely investigated for repair of focal defects in articular cartilage. However, the amount and/or type of extracellular matrix (ECM) produced in engineered constructs does not always correlate with the resultant mechanical properties. This could be related to the specifics...

journal_title：Annals of the New York Academy of Sciences

authors： Karchner JP,Querido W,Kandel S,Pleshko N

更新日期：2019-04-01 00:00:00

abstract：:In this paper, the topic of laminar to turbulent flow transition, as applied to the design of gas turbines, is discussed. Transition comes about when a flow becomes sufficiently unstable that the orderly vorticity structure of the laminar layer becomes randomly oriented. Vorticity with a streamwise component leads to ...

journal_title：Annals of the New York Academy of Sciences

authors： Simon TW,Kaszeta RW

更新日期：2001-05-01 00:00:00

abstract：:Reactive oxygen species have been known to cause DNA damage and induce apoptosis. During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis. Recent reports have shown that NF-kappaB plays a critica...

journal_title：Annals of the New York Academy of Sciences

authors： Song JY,Lim JW,Kim H,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:The mechanism by which neurons and neurosecretory cells govern the expression and the exocytic discharge of their clear and dense-core vesicles had remained unclear until recently when studies in the neurosecretory cell model PC12 revealed these processes to be orchestrated by the transcriptional repressor neuron rest...

journal_title：Annals of the New York Academy of Sciences

authors： D'Alessandro R,Klajn A,Meldolesi J

更新日期：2009-01-01 00:00:00