Dopamine uptake blockers nullify methamphetamine-induced decrease in dopamine uptake and plasma membrane potential in rat striatal synaptosomes.

Abstract:

:Rat striatal synaptosomes showed a reduced capacity to generate a membrane potential after being exposed to methamphetamine (METH) for 1 h. As a consequence, the dopamine (DA) synaptosomes were impeded in their electrogenic-dependent reuptake of dopamine. The capacity for METH-exposed nerve terminals to generate a membrane potential may contribute to the ability of METH to destroy dopaminergic neurons. DA uptake inhibitors (DAUIs) were found to counteract the METH-induced decrease in synaptosomal [3H]DA Vmax by stablizing METH-induced reductions in PMP. Because DAUIs showed the same effects as a Na+-channel blocker, DAUIs may prevent METH-induced destruction of dopaminergic neurons by raising plasma membrane potential.

journal_name

Ann N Y Acad Sci

authors

Westphalen RI,Stadlin A

doi

10.1111/j.1749-6632.2000.tb05195.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

187-93

eissn

0077-8923

issn

1749-6632

journal_volume

914

pub_type

杂志文章
  • Antiproliferative effects of retinoids related to the cell cycle-specific inhibition of ornithine decarboxylase.

    abstract::The induction of ornithine decarboxylase (ODC) during G1 phase of the cell cycle appears to be universal and essential for cell cycle progression. This induction has been demonstrated in at least 23 cell types in response to various growth stimuli. Further, specific inhibitors of ODC added to several of these cell lin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1981.tb12754.x

    authors: Russell DH,Haddox MK

    更新日期:1981-02-27 00:00:00

  • ACE inhibitor captopril reduces ecdysteroids and oviposition in moths.

    abstract::By using the selective ACE inhibitor captopril, we studied the effect of the angiotensin converting enzyme (ACE) on larval growth, metamorphosis, and reproduction in a lepidopteran species, the cotton leafworm, Spodoptera littoralis. Captopril was detrimental to adult formation and oviposition, and in female moths it ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1327.102

    authors: Vercruysse L,Gelman D,van de Velde S,Raes E,Hooghe B,Vermeirssen V,van Camp J,Smagghe G

    更新日期:2005-04-01 00:00:00

  • Structure/function studies of the gamma subunit of the Na,K-ATPase.

    abstract::The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07224.x

    authors: Blostein R,Pu HX,Scanzano R,Zouzoulas A

    更新日期:2003-04-01 00:00:00

  • Evaluation of a novel line-blot immunoassay for the detection of antibodies to extractable nuclear antigens.

    abstract::We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1313.036

    authors: Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

    更新日期:2005-06-01 00:00:00

  • Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment.

    abstract::We evaluated immune and endocrine status following antituberculosis treatment in HIV-negative patients with newly diagnosed tuberculosis (TB). Treatment led to a decrease in IL-6, IL-1β, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after 4 months, but changes ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2012.06643.x

    authors: Bongiovanni B,Díaz A,D'Attilio L,Santucci N,Dídoli G,Lioi S,Nannini LJ,Gardeñez W,Bogue C,Besedovsky H,del Rey A,Bottasso O,Bay ML

    更新日期:2012-07-01 00:00:00

  • Effect of resveratrol on fat mobilization.

    abstract::Higher levels of body fat are associated with increased risk for development of numerous adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing adipose tissue mass. Resveratrol decrea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05845.x

    authors: Baile CA,Yang JY,Rayalam S,Hartzell DL,Lai CY,Andersen C,Della-Fera MA

    更新日期:2011-01-01 00:00:00

  • Visual skills and cross-modal plasticity in deaf readers: possible implications for acquiring meaning from print.

    abstract::Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1416.013

    authors: Dye MW,Hauser PC,Bavelier D

    更新日期:2008-12-01 00:00:00

  • Lumbar spine bone mineral density changes in patients with primary hyperparathyroidism according to age and gender.

    abstract::Primary hyperparathyroidism (PHPT) results from excessive secretion of parathyroid hormone (PTH), and catabolic and anabolic effects of PTH on bone may lead to overall deleterious effects on skeleton. The aim of this study was to analyze the changes in lumbar spine bone mineral density (BMD) in patients with PHPT who ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1402.031

    authors: Lumachi F,Camozzi V,Ermani M,Nardi A,Luisetto G

    更新日期:2007-11-01 00:00:00

  • Saliva testing for drugs of abuse.

    abstract::Saliva testing for drugs of abuse can provide both qualitative and quantitative information on the drug status of an individual undergoing testing. Self-administration by the oral, intranasal, and smoking routes often produces "shallow depots" of drug that contaminate the oral cavity. This depot produces elevated drug...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb18346.x

    authors: Cone EJ

    更新日期:1993-09-20 00:00:00

  • Mechanisms of matrix degradation in rheumatoid arthritis.

    abstract::In the inflammatory synovium production of collagenase is probably responsible for the degradation of collagen in the extracellular matrix and distortion of the architecture and function of the joints. Major collagenase-producing cells are mesenchymal cells such as fibroblasts and chondrocytes, which synthesize and se...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb17943.x

    authors: Krane SM,Conca W,Stephenson ML,Amento EP,Goldring MB

    更新日期:1990-01-01 00:00:00

  • Monoclonal antibodies to desmin: evidence for stage-dependent intermediate filament immunoreactivity during cardiac and skeletal muscle development.

    abstract::Monoclonal antibodies reactive with desmin (D3 and D76) have been generated and their specificities validated by immunoblots, RIAs, and immunocytochemistry. No cross-reaction with other IFPs has been observed. The McAbs recognized different epitopes but both reside in the amino-terminal rod domain of desmin. Whereas M...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb50411.x

    authors: Fischman DA,Danto SI

    更新日期:1985-01-01 00:00:00

  • Regulatory B cells in autoimmune diseases: how do they work?

    abstract::B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04651.x

    authors: Lemoine S,Morva A,Youinou P,Jamin C

    更新日期:2009-09-01 00:00:00

  • Ecology of avian influenza viruses in a changing world.

    abstract::Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza vir...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05451.x

    authors: Vandegrift KJ,Sokolow SH,Daszak P,Kilpatrick AM

    更新日期:2010-05-01 00:00:00

  • Stress, leukocyte trafficking, and the augmentation of skin immune function.

    abstract::Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb03151.x

    authors: Dhabhar FS

    更新日期:2003-05-01 00:00:00

  • Abnormalities of energy metabolism in Alzheimer's disease studied with PET.

    abstract::Positron emission tomography (PET) is currently the only technology affording three-dimensional measurement of the brain's energy metabolism which is closely coupled to brain function. Studies of glucose metabolism by PET of (18F)-2-fluoro-2-deoxy-D-glucose are therefore widely applied to show the contribution of vari...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb00192.x

    authors: Heiss WD,Szelies B,Kessler J,Herholz K

    更新日期:1991-01-01 00:00:00

  • Scientific aspects that justify the benefits of the Mediterranean diet: mild-to-moderate versus heavy drinking.

    abstract::The Mediterranean diet is now recognized as being both limited in toxicity and abundant in nutrient and non-nutrient protective factors. A large body of basic, clinical and epidemiological studies have been developed in recent years to provide evidence of the benefits of the Mediterranean diet or its components on hea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb02914.x

    authors: Covas MI,Marrugat J,Fitó M,Elosua R,de la Torre-Boronat C

    更新日期:2002-05-01 00:00:00

  • A systematic-heuristic approach for space trajectory design.

    abstract::In this paper a novel algorithm is proposed for space trajectory design that combines a systematic and a heuristic method for global optimization. For the systematic part of the algorithm a branching technique is used, whereas a particular implementation of evolution programming forms the core of the heuristic part. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1311.014

    authors: Vasile M

    更新日期:2004-05-01 00:00:00

  • Basal ganglia mechanisms of reward-oriented eye movement.

    abstract::Expectation of reward facilitates motor behaviors that enable the animal to approach a location in space where the reward is expected. It is now known that the same expectation of reward profoundly modifies sensory, motor, and cognitive information processing in the brain. However, it is still unclear which brain regi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1390.012

    authors: Hikosaka O

    更新日期:2007-05-01 00:00:00

  • Innovative ways of studying the effect of migration on obesity and diabetes beyond the common designs: lessons from the RODAM study.

    abstract::Type 2 diabetes and obesity are major global public health problems, with migrant populations in high-income countries being particularly affected. Type 2 diabetes and obesity are also major threats in low- and middle-income countries, from which most migrant populations originate. Transitioning of societies and the r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13204

    authors: Agyemang C,Beune E,Meeks K,Addo J,Aikins AD,Bahendeka S,Danquah I,Mockenhaupt FP,Schulze MB,Klipstein-Grobusch K,Smeeth L,Stronks K

    更新日期:2017-03-01 00:00:00

  • Taste. Robust across the age span?

    abstract::The prevalence of taste loss over a discrete area of the tongue or palate is unknown; however, we have identified discrete losses in three etiological groups: head trauma, upper respiratory infection, and bulimia. We have now identified discrete losses in elderly subjects. To summarize, elderly subjects show elevated ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1989.tb20970.x

    authors: Bartoshuk LM

    更新日期:1989-01-01 00:00:00

  • Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism.

    abstract::Tocopherols are known to undergo metabolism to phytyl chain-shortened metabolites excreted in urine. We sought to characterize the pathway, including associated enzymes, involved in this biotransformation. We previously found that human hepatoblastoma (HepG2) cultures metabolized tocopherols to their corresponding sho...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1331.002

    authors: Parker RS,Sontag TJ,Swanson JE,McCormick CC

    更新日期:2004-12-01 00:00:00

  • A summary of the contributions of the VA cooperative studies on abdominal aortic aneurysms.

    abstract::The Department of Veterans Affairs Cooperative Studies Program has completed two studies on abdominal aortic aneurysm (AAA) and is currently conducting a third. The first, the Aneurysm Detection and Management (ADAM) Study, consisted of both a screening program, which provided information on the prevalence and associa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1383.039

    authors: Lederle FA

    更新日期:2006-11-01 00:00:00

  • What does the head impulse test versus caloric dissociation reveal about vestibular dysfunction in Ménière's disease?

    abstract::In patients with Ménière's disease (MD), caloric testing can show, depending on the stage and activity of the disease, a variety of results. Between attacks, many, or perhaps even most, patients with unilateral early or mild MD have normal caloric tests; late MD can show abnormalities ranging from mild to severe unila...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.12687

    authors: McGarvie LA,Curthoys IS,MacDougall HG,Halmagyi GM

    更新日期:2015-04-01 00:00:00

  • C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies.

    abstract::Recent findings indicate that complement activation--involving specifically C3 and C5--contributes to antiphospholipid (aPL)-mediated thrombosis. Two complement effector pathways are initiated by the cleavage of C5, C5a and C5b, which leads to the formation of the C5b-9 membrane attack complex. To delineate and distin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1422.058

    authors: Romay-Penabad Z,Liu XX,Montiel-Manzano G,Papalardo De Martínez E,Pierangeli SS

    更新日期:2007-06-01 00:00:00

  • An attempt to do without dark matter.

    abstract::The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb05627.x

    authors: Kinney WH,Brisudova M

    更新日期:2001-06-01 00:00:00

  • Trends in private insurance, Medicaid/State Children's Health Insurance Program, and the Healthcare Safety Net: implications for vulnerable populations and health disparities.

    abstract::This chapter examines trends in private and public health coverage, as well as implications for vulnerable populations and health disparities. We find that there has been erosion in employment-based health benefits. Both the percentage of employers offering coverage and the percentage of workers with coverage declined...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1425.029

    authors: Shields AE,McGinn-Shapiro M,Fronstin P

    更新日期:2008-01-01 00:00:00

  • Humanized mice for the study of type 1 and type 2 diabetes.

    abstract::The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06318.x

    authors: Greiner DL,Brehm MA,Hosur V,Harlan DM,Powers AC,Shultz LD

    更新日期:2011-12-01 00:00:00

  • The carcinogenicity of chrysotile asbestos.

    abstract::In in vitro test systems, chrysotile is markedly toxic, causes chromosomal aberrations, and is capable of inducing morphological and preneoplastic transformation. In carefully designed animal experiments, chrysotile produces lung cancer and mesothelioma as effectively as do the amphiboles tested. Human population stud...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1991.tb24496.x

    authors: Harington JS

    更新日期:1991-12-31 00:00:00

  • Micronutrients and their influence on mutagenicity and malignant transformation.

    abstract::Many studies have now indicated that micronutrients, such as the carotenoids, tocopherols, and ascorbic acid, can prevent mutagenesis, genotoxic effects, or malignant transformation in bacteria and mammalian tissue, either in cell culture or in organ culture. In addition, multiple papers report that some of these micr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb39180.x

    authors: Krinsky NI

    更新日期:1993-05-28 00:00:00

  • What and how do we communicate?

    abstract::The rapid, inexpensive transmission of words and data, brought about by the internet and cheap computers, is changing the world faster than anything mankind has ever experienced, reaching into nearly every aspect of our lives, public and private, commercial and governmental. We are in an Information Age with an essent...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05267.x

    authors: Hugh-Jones M

    更新日期:2000-01-01 00:00:00