Nicotinic acetylcholine receptors on vagal afferent neurons.

abstract：:The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovari...

journal_title：Annals of the New York Academy of Sciences

authors： Kalantaridou SN,Chrousos GP

更新日期：2000-01-01 00:00:00

abstract：:This paper describes the flight experiment, supporting ground science, and the design rationale for a project on spaceflight holography investigation in a virtual apparatus (SHIVA). SHIVA is a fundamental study of particle dynamics in fluids in microgravity. Gravitation effects and steady Stokes drag often dominate th...

journal_title：Annals of the New York Academy of Sciences

authors： Trolinger JD,L'Esperance D,Rangel RH,Coimbra CF,Witherow WK

更新日期：2004-11-01 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:The first step in cancer initiation is the reaction of chemical carcinogens with DNA to form stable adducts, which remain in DNA unless removed by repair, and depurinating adducts, which detach from DNA following destabilization of the glycosyl bond. Depurinating DNA adducts of polycyclic aromatic hydrocarbons play a ...

journal_title：Annals of the New York Academy of Sciences

authors： Cavalieri EL,Rogan EG

更新日期：2004-12-01 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Hypomethylation signifies one end of a spectrum of DNA methylation states. In most cases hypomethylation refers to a relative state that represents a change from the "normal" methylation level. Hypomethylation, when approached from a topographical perspective, has been used to describe either overall decreases in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Dunn BK

更新日期：2003-03-01 00:00:00

abstract：:We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While the mechanism of this protection has largely been thought to be due to their chaperone functions (i.e., preventing abnormal pro...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Liu J,Zheng Z,Vexler ZS,Lee JE,Giffard RG

更新日期：2005-08-01 00:00:00

abstract：:Gonadal hormones, particularly androgens, direct certain aspects of brain development and exert permanent influences on sex-typical behavior in nonhuman mammals. Androgens also influence human behavioral development, with the most convincing evidence coming from studies of sex-typical play. Girls exposed to unusually ...

journal_title：Annals of the New York Academy of Sciences

authors： Hines M

更新日期：2003-12-01 00:00:00

abstract：:Forests are one of Earth's critical biomes. They have been shown to respond strongly to many of the drivers that are predicted to change natural systems over this century, including climate, introduced species, and other anthropogenic influences. Predicting how different tree species might respond to this complex of f...

journal_title：Annals of the New York Academy of Sciences

authors： McMahon SM,Dietze MC,Hersh MH,Moran EV,Clark JS

更新日期：2009-04-01 00:00:00

abstract：:In type 1 diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 antib...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta M,Graham J,McNeeny B,Zarghami M,Landin-Olsson M,Hagopian WA,Palmer J,Lernmark A,Sanjeevi CB

更新日期：2006-10-01 00:00:00

abstract：:Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...

journal_title：Annals of the New York Academy of Sciences

authors： Stokbro K,Taylor J,Brandbyge M,Ordejón P

更新日期：2003-12-01 00:00:00

abstract：:Mitochondrial dysfunction is implicated in many forms of cell death, particularly in the central nervous system. The mitochondria are required at the same time to generate adenosine 5'-triphosphate (ATP) for the cell, sequester excess cytoplasmic Ca(2+), and both produce and detoxify superoxide free radicals. The elec...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholls DG

更新日期：2008-12-01 00:00:00

abstract：:Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

journal_title：Annals of the New York Academy of Sciences

authors： Surh YJ,Lee JY,Choi KJ,Ko SR

更新日期：2002-11-01 00:00:00

abstract：:Apolipoprotein E is a plasma cholesterol and phospholipid transporter which plays a central role in lipoprotein metabolism in the brain. Apolipoprotein E is a polymorphic protein with three common alleles in the general population, designated epsilon 2, epsilon 3 and epsilon 4 coding for proteins ApoE2, ApoE3 and ApoE...

journal_title：Annals of the New York Academy of Sciences

authors： Beffert U,Poirier J

更新日期：1996-01-17 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is a multifactorial disease. Besides a genetic predisposition environmental factors have been implicated in the pathogenesis of beta cell destruction. Among these environmental factors viruses have been the focus of many studies. Some viruses are diabetogenic in animals, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Jaeckel E,Manns M,Von Herrath M

更新日期：2002-04-01 00:00:00

abstract：:Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose. The effect partly wanes with time. There is reduced islet inflammation. Similar protective effects can be demonstrated in quasi-experimental interventions in humans--both diabetes related and unrelated deemed at risk of ...

journal_title：Annals of the New York Academy of Sciences

authors： Elliott RB,Pilcher CC,Stewart A,Fergusson D,McGregor MA

更新日期：1993-11-30 00:00:00

abstract：:Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types. It is well established that some of the catabolic effects of the proinflammatory cytokines interleukin-1beta (IL-1beta) and ...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze-Tanzil G,Mobasheri A,Sendzik J,John T,Shakibaei M

更新日期：2004-12-01 00:00:00

abstract：:A total of 1,098 serum samples were analyzed against Anaplasma phagocytophilum by immunofluorescent antibody (IFA) test. These serum samples belonged to four different populations distributed throughout two provinces of Galicia (Ourense and Pontevedra) located in northwestern Spain: bovine population (456 samples); ov...

journal_title：Annals of the New York Academy of Sciences

authors： Amusategui I,Sainz A,Tesouro MA

更新日期：2006-10-01 00:00:00

abstract：:The aim of the study was to investigate the effect of functional polymorphisms in promoters of the MMP-2 (-1306 C > T), MMP-3 (-1171 5A > 6A), MMP-9 (-1562 C > T), MMP-12 (-82 A > G), TIMP-1 (-372 C > T), and PAI-1 (-675 4G > 5G and -847 A > G) genes on the growth rate of small abdominal aortic aneurysms. The patients...

journal_title：Annals of the New York Academy of Sciences

authors： Powell JT

更新日期：2006-11-01 00:00:00

abstract：:Patients with vascular dementia are frequently encountered in Japan reaching nearly 50% of those with senile dementia, which is equal to or even slightly higher than patients with Alzheimer's disease. This contrasts with a much lower ratio of patients with vascular dementia in the United States. The majority of vascul...

journal_title：Annals of the New York Academy of Sciences

authors： Yanagihara T

更新日期：2002-11-01 00:00:00

abstract：:The therapeutic value of thymectomy for myasthenia is still questioned although it retains an important place among management modalities that strive for sustained remission. Questions derive from uncertainty as to appropriate timing, variable extent of resection and quantitation of response. Forty-seven patients, fol...

journal_title：Annals of the New York Academy of Sciences

authors： Penn AS,Jaretzki A 3rd,Wolff M,Chang HW,Tennyson V

更新日期：1981-01-01 00:00:00

abstract：:The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distrib...

journal_title：Annals of the New York Academy of Sciences

authors： Marcos Z,Bodegas ME,Sesma MP,Guembe L

更新日期：2005-04-01 00:00:00

abstract：:Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

journal_title：Annals of the New York Academy of Sciences

authors： Haaga J,O'Connor K,Weinstein M,Wise P

更新日期：2010-08-01 00:00:00

abstract：:In response to tissue injury elicited by trauma or infection, the inflammatory response, as a complex network of molecular and cellular interactions, sets an answer directed to facilitate a return to physiological homeostasis and tissue repair. The role of the genetic background and the subsequent predisposition towar...

journal_title：Annals of the New York Academy of Sciences

authors： Grimaldi MP,Vasto S,Balistreri CR,di Carlo D,Caruso M,Incalcaterra E,Lio D,Caruso C,Candore G

更新日期：2007-04-01 00:00:00

abstract：:Release of the amyloid precursor protein (APP) of Alzheimer's disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate. In fibroblasts overexpressing protein kinase C alpha (PKC alpha), the EC50 for this response was 7 nM, while in control cells the EC50 ...

journal_title：Annals of the New York Academy of Sciences

authors： Slack BE,Nitsch RM,Livneh E,Kunz GM Jr,Eldar H,Wurtman RJ

更新日期：1993-09-24 00:00:00

abstract：:Researchers in Utrecht, the Netherlands have studied the effects of different factors, such as oral contraceptives (OCs), on sex hormone binding globulin (SHBG) levels in blood. The SHBG levels in women who continuously used OCs consisting only of .05 mg of ethinyl estradiol (EE2) rose as high as 260% + or - 25% of t...

journal_title：Annals of the New York Academy of Sciences

authors： Thijssen JH

更新日期：1988-01-01 00:00:00

abstract：:We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HL...

journal_title：Annals of the New York Academy of Sciences

authors： Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello SS,Fernandes AP,Deghaide NN,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2006-10-01 00:00:00

abstract：:The contemporary world faces an unprecedented environmental challenge. Past international research has amply shown that we cannot afford to wait for a "development path" that automatically takes us on a sustainable future. Whether we look at global or local problems, the international debate increasingly points to the...

journal_title：Annals of the New York Academy of Sciences

authors： Magnani E

更新日期：2011-02-01 00:00:00

abstract：:Chronic hypoxic stimulation in mammals can induce several phenotypic changes, such as polycythemia, pulmonary vascular changes, pulmonary hypertension, and carotid body (CB) enlargement. These phenotypic alterations provide a tool to test whether an oxygen sensor candidate is involved in an organism's response to envi...

journal_title：Annals of the New York Academy of Sciences

authors： Baysal BE

更新日期：2006-08-01 00:00:00

abstract：:Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic...

journal_title：Annals of the New York Academy of Sciences

authors： Van Loon GR,Sole MJ,Kamble A,Kim C,Green S

更新日期：1977-10-28 00:00:00