Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?

abstract：:Emerging evidence suggests that individuals who receive morphine while hospitalized demonstrate a decrease in symptoms of posttraumatic stress disorder (PTSD). However, the mechanisms of effects are not yet well understood. The goal of the current study was to examine three possible mediators for this effect. Sixty-on...

journal_title：Annals of the New York Academy of Sciences

authors： Saxe G,Geary M,Bedard K,Bosquet M,Miller A,Koenen K,Stoddard F,Moulton S

更新日期：2006-07-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:Our cumulative experience continues to validate the fetal nucleated erythrocyte as the target fetal cell type of choice, primarily because it reflects the cytogenetic status of the current pregnancy. Additional cell types, such as the granulocyte, await further study. Quantitative PCR is a sensitive and useful new met...

journal_title：Annals of the New York Academy of Sciences

authors： Bianchi DW

更新日期：1994-09-07 00:00:00

abstract：:Maize (Zea mays), also called corn, is believed to have originated in central Mexico 7000 years ago from a wild grass, and Native Americans transformed maize into a better source of food. Maize contains approximately 72% starch, 10% protein, and 4% fat, supplying an energy density of 365 Kcal/100 g and is grown throug...

journal_title：Annals of the New York Academy of Sciences

authors： Ranum P,Peña-Rosas JP,Garcia-Casal MN

更新日期：2014-04-01 00:00:00

abstract：:Despite intense efforts, little is known about the etiology of prostate cancer, and treatment of advanced forms of the disease has had limited success. Nonetheless, epidemiologic studies combined with animal model and in vitro experiments indicate that natural components of the diet, including n-3 PUFA, the carotenoid...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen LA

更新日期：2002-06-01 00:00:00

abstract：:This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

journal_title：Annals of the New York Academy of Sciences

authors： Azimov D,Bishop R

更新日期：2005-12-01 00:00:00

abstract：:To test whether the development of emotional resilience is a function of sensitive caregiving and child negative affect, we tested the joint contributions of 7-month maternal sensitivity and infant negative affect to the prediction of 33-month emotional resilience across the first 3 years of life. The aims of this stu...

journal_title：Annals of the New York Academy of Sciences

authors： Conway AM,McDonough SC

更新日期：2006-12-01 00:00:00

abstract：:We showed the presence of glucocorticoid (GR) and mineralocorticoid (MR) receptors in different populations of Xenopus laevis melanotrope cells and revealed their downregulation (MR) and upregulation (GR) during dark background adaptation. Corticosterone did not affect short-term intracellular calcium dynamics and alp...

journal_title：Annals of the New York Academy of Sciences

authors： Roubos EW,Kuribara M,Kuipers-Kwant FJ,Coenen TA,Meijer KH,Cruijsen PM,Denver RJ

更新日期：2009-04-01 00:00:00

abstract：:According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heav...

journal_title：Annals of the New York Academy of Sciences

authors： Song W,Barth JL,Lu K,Yu Y,Huang Y,Gittinger CK,Argraves WS,Lyons TJ

更新日期：2005-06-01 00:00:00

abstract：:The essential trace element selenium is of fundamental importance to human biology. Information on the membrane-bound selenoproteins was obtained by labeling of rats in vivo with (75)Se-selenite, subcellular fractionation of the tissue homogenates, separation of the proteins by SDS-PAGE, two-dimensional electrophoresi...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bertelsmann H,Graebert A,Hoppe B,Kuhbacher M,Behne D

更新日期：2002-11-01 00:00:00

abstract：:The present study investigates the impact of emotional deficits on implicit and explicit memory for musical stimuli in patients with Alzheimer's disease and elderly depressed patients. Results showed that unlike Alzheimer's patients, depressed patients were unable to develop a positive affective bias of judgment for p...

journal_title：Annals of the New York Academy of Sciences

authors： Quoniam N,Ergis AM,Fossati P,Peretz I,Samson S,Sarazin M,Allilaire JF

更新日期：2003-11-01 00:00:00

abstract：:The availability of new food composition carotenoid values for fruits and vegetables increases our ability to test hypotheses concerning the role of antioxidant nutrients and cancer risk. To estimate the usual carotenoid intakes, a quantitative diet history covering a one-year period is recommended for epidemiologic s...

journal_title：Annals of the New York Academy of Sciences

authors： Hankin JH,Le Marchand L,Kolonel LN,Wilkens LR

更新日期：1993-12-31 00:00:00

abstract：:The clinical, epidemiological, and therapeutic aspects of 15 patients with Mediterranean spotted fever (MSF), admitted to the Internal Medicine Department of the General Hospital of Sitia (southeastern Crete, Greece) between December 2000 and July 2003, were studied. Diagnosis was made on the basis of clinical signs a...

journal_title：Annals of the New York Academy of Sciences

authors： Germanakis A,Psaroulaki A,Gikas A,Tselentis Y

更新日期：2006-10-01 00:00:00

abstract：:Certain livestock diseases in sub-Saharan Africa, such as foot-and-mouth disease are difficult to control because of the large numbers of infected wildlife hosts. These wildlife disease reservoirs form a continuous hazard of transmittal of the diseases to domestic livestock, which limits the access of livestock produc...

journal_title：Annals of the New York Academy of Sciences

authors： Sutmoller P

更新日期：2002-10-01 00:00:00

abstract：:These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...

journal_title：Annals of the New York Academy of Sciences

authors： Ferris CF,Brewer J

更新日期：1996-09-20 00:00:00

abstract：:The discovery of RNA interference (RNAi) in C. elegans and in plants has revolutionized current approaches to biology and medicine. RNAi silences genes in a sequence-specific manner through the actions of small pieces of double-stranded RNAs (siRNAs and miRNAs). RNAi has been found as a widespread natural phenomenon i...

journal_title：Annals of the New York Academy of Sciences

authors： Zheng ZM,Tang S,Tao M

更新日期：2005-11-01 00:00:00

abstract：:Effects of sunlight have fascinated researchers for decades because nearly every living thing on earth is likely to be exposed to sunlight and the ultraviolet (UV) fraction of it. In addition to detrimental long-term effects such as immunosuppression and skin cancer, premature aging of the skin (photoaging) is a well-...

journal_title：Annals of the New York Academy of Sciences

authors： Brenneisen P,Sies H,Scharffetter-Kochanek K

更新日期：2002-11-01 00:00:00

abstract：:Moderated by Lisa Miller from Newsweek, evolutionary biologist Kenneth Miller (Brown University) and theologians John Haught (Georgetown University) and Nancey Murphy (Fuller Theological Seminary) discuss the questions Are we immortal? Do our souls exist beyond our bodies? and What scientific evidence is there for mys...

journal_title：Annals of the New York Academy of Sciences

authors： Miller L,Miller K,Haught J,Murphy N

更新日期：2011-10-01 00:00:00

abstract：:The study of music perception and cognition is one of the oldest topics in experimental psychology. The last 20 years have seen an increased interest in understanding the functional neuroanatomy of music processing in humans, using a variety of technologies including fMRI, PET, ERP, MEG, and lesion studies. We review ...

journal_title：Annals of the New York Academy of Sciences

authors： Levitin DJ,Tirovolas AK

更新日期：2009-03-01 00:00:00

abstract：:Human alpha 2-antiplasmin (alpha 2AP) is the primary inhibitor of plasmin-mediated fibrinolysis and is an efficient substrate of activated factor XIII (FXIIIa). Among 452 amino acid residues in alpha 2AP, Gln2 is believed to be the sole FXIIIa-reactive site that participates in crosslinking alpha 2AP to fibrin. We stu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee KN,Lee CS,Tae WC,Jackson KW,Christiansen VJ,McKee PA

更新日期：2001-01-01 00:00:00

abstract：:Immunoglobulin 4 (IgG4) is one of four human IgG subclasses and has several unique functional characteristics. It exhibits low affinity for complement and for most Fc receptors. It furthermore has generally high affinity for its antigen, with binding occurring in a monovalent fashion, as IgG4 can exchange Fab-arms wit...

journal_title：Annals of the New York Academy of Sciences

authors： Huijbers MG,Plomp JJ,van der Maarel SM,Verschuuren JJ

更新日期：2018-02-01 00:00:00

abstract：:Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

journal_title：Annals of the New York Academy of Sciences

authors： Anji A,Shaik KA,Kumari M

更新日期：2003-05-01 00:00:00

abstract：:This paper discusses the repatriation of human remains to indigenous peoples in Australia and the United States and the role anthropologists play in the construction of past, present, and future identities for contemporary indigenous peoples. Using examples from both countries, I suggest that many of the participants ...

journal_title：Annals of the New York Academy of Sciences

authors： Cantwell AM

更新日期：2000-01-01 00:00:00

abstract：:Though several studies show that genetic factors influence individual differences in musical engagement, aptitude, and achievement, no study to date has investigated whether specialization among musically active individuals in terms of choice of instrument and genre is heritable. Using a large twin cohort, we explored...

journal_title：Annals of the New York Academy of Sciences

authors： Mosing MA,Ullén F

更新日期：2018-05-09 00:00:00

abstract：:Clostridium difficile infection, also known as C. difficile-associated diarrhea (CDAD), is the most common cause of nosocomial diarrhea, typically initiated by the use of broad-spectrum antibiotics that disrupt gut flora, thereby allowing C. difficile to proliferate. It is an increasing cause of morbidity and mortalit...

journal_title：Annals of the New York Academy of Sciences

authors： Sears P,Ichikawa Y,Ruiz N,Gorbach S

更新日期：2013-07-01 00:00:00

abstract：:Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

journal_title：Annals of the New York Academy of Sciences

authors： Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

更新日期：2005-06-01 00:00:00

abstract：:Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut perme...

journal_title：Annals of the New York Academy of Sciences

authors： Sung MK,Yeon JY,Park SY,Park JH,Choi MS

更新日期：2011-07-01 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:Fifty-eight contributors from 12 European and 2 American sarcoidosis centers have collaborated in a survey to define many questions concerning the use of 67Ga lung scan in sarcoidosis. The new quantitative scoring methods based on digital evaluation seem better in detecting lung activity. In 20.1% of untreated patient...

journal_title：Annals of the New York Academy of Sciences

authors： Rizzato G,Blasi A

更新日期：1986-01-01 00:00:00

abstract：:Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selective delivery of therapeutic agents to the central nervous system. Primary cultures of brain microvessel endothelial cells offer a ...

journal_title：Annals of the New York Academy of Sciences

authors： Audus KL,Borchardt RT

更新日期：1987-01-01 00:00:00