Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: the role of glucocorticoids.

Abstract:

:The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.

journal_name

Ann N Y Acad Sci

authors

Priego T,Ibañez De Cáceres I,Martín AI,Villanúa MA,López-Calderón A

doi

10.1111/j.1749-6632.2002.tb04612.x

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

88-90

eissn

0077-8923

issn

1749-6632

journal_volume

973

pub_type

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