Inflammation in psychiatric disorders: what comes first?

abstract：:Translin and translin-associated factor X (translin/TRAX) proteins have been implicated in a variety of cellular activities central to nucleic acid metabolism. Accumulating evidence indicates that translin/TRAX complexes participate in processes ensuring the replication of DNA, as well as cell division. Significant pr...

journal_title：Annals of the New York Academy of Sciences

authors： Kasai M,Ishida R,Nakahara K,Okumura K,Aoki K

更新日期：2018-06-01 00:00:00

abstract：:Sensorimotor learning requires knowledge of the relationship between movements and sensory effects: a sensorimotor map. Generally, these mappings are not innate but have to be learned. During learning, the challenge is to build a continuous map from a set of discrete observations, that is, predict locations of novel t...

journal_title：Annals of the New York Academy of Sciences

authors： van Vugt FT,Ostry DJ

更新日期：2018-03-03 00:00:00

abstract：:The hypothesis tested was that mutant tumor DNA shed into plasma would show predictive value for monitoring response to therapy in non-small cell lung carcinoma patients. Pretreatment plasma specimens from 25 patients on a phase I trial were evaluated, 12 with paired posttreatment specimens, and 138 patients on the So...

journal_title：Annals of the New York Academy of Sciences

authors： Kimura T,Holland WS,Kawaguchi T,Williamson SK,Chansky K,Crowley JJ,Doroshow JH,Lenz HJ,Gandara DR,Gumerlock PH

更新日期：2004-06-01 00:00:00

abstract：:We examined the effects of a nonantimicrobial tetracycline analogue, CMT-8, on bone loss and osteoclasts in ovariectomized (OVX) rats. Three-month-old female rats were OVX, and, one week later, distributed into three groups: sham-operated non-OVX controls, untreated OVX controls, and CMT-8-treated OVX rats. After 145 ...

journal_title：Annals of the New York Academy of Sciences

authors： Sasaki T,Ohyori N,Debari K,Ramamurthy NS,Golub LM

更新日期：1999-06-30 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:VH replacement occurs through RAG-mediated recombination between a cryptic recombination signal sequence (cRSS) presented in a rearranged VH gene and a 23-bp RSS from an upstream VH gene. VH replacement renews the entire VH coding region and extends the immunoglobulin heavy-chain (IgH) CDR3 regions preferentially with...

journal_title：Annals of the New York Academy of Sciences

authors： Liu Y,Fan R,Zhou S,Yu Z,Zhang Z

更新日期：2005-12-01 00:00:00

abstract：:Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

journal_title：Annals of the New York Academy of Sciences

authors： Hertzman C

更新日期：1999-01-01 00:00:00

abstract：:Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younge...

journal_title：Annals of the New York Academy of Sciences

authors： Landin-Olsson M

更新日期：2002-04-01 00:00:00

abstract：:Amyloid precursor proteins (APP) are a member of a larger family of proteins that include the amyloid precursor-like proteins (APLP) APLPI and APLP2. We have examined the expression and metabolism of APLP2 and document that APLP2 is expressed at high levels in the nervous system and in peripheral tissues. Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Sisodia SS,Thinakaran G,Slunt HH,Kitt CA,Von Koch CS,Reed RR,Zheng H,Price DL

更新日期：1996-01-17 00:00:00

abstract：:One of the most striking changes in the primary lymphoid organs during human aging is the progressive involution of the thymus. As a consequence, the rate of naïve T cell output dramatically declines with age and the peripheral T cell pool shrinks. These changes lead to increased incidence of severe infections and dec...

journal_title：Annals of the New York Academy of Sciences

authors： Pfister G,Weiskopf D,Lazuardi L,Kovaiou RD,Cioca DP,Keller M,Lorbeg B,Parson W,Grubeck-Loebenstein B

更新日期：2006-05-01 00:00:00

abstract：:The authors report their experience in the surgical treatment of bone deformities in osteogenesis imperfecta, based upon 45 operations in 13 severely affected patients. Three different procedures were used. Fragmentation and temporary fixation by means of a wire does not guarantee a sufficient protection of the bone a...

journal_title：Annals of the New York Academy of Sciences

authors： Brunelli PC,Frediani P

更新日期：1988-01-01 00:00:00

abstract：:A brief description of the information content of the experimental methods that are becoming increasingly useful for probing intracellular processes, a framework for interpreting observations, and an example that combines framework results and 13C NMR observations have been presented. Results in terms of structural cr...

journal_title：Annals of the New York Academy of Sciences

authors： Domach MM,Majewski RA

更新日期：1987-01-01 00:00:00

abstract：:Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a D-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on t...

journal_title：Annals of the New York Academy of Sciences

authors： Patzer JF 2nd,Mazariegos GV,Lopez R,Molmenti E,Gerber D,Riddervold F,Khanna A,Yin WY,Chen Y,Scott VL,Aggarwal S,Kramer DJ,Wagner RA,Zhu Y,Fulmer ML,Block GD,Amiot BP

更新日期：1999-06-18 00:00:00

abstract：:Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects. We found five RXFP2 mutations in five bilateral ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferlin A,Zuccarello D,Garolla A,Selice R,Vinanzi C,Ganz F,Zanon GF,Zuccarello B,Foresta C

更新日期：2009-04-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stress than do normal c...

journal_title：Annals of the New York Academy of Sciences

authors： Suh DH,Kim MK,Kim HS,Chung HH,Song YS

更新日期：2012-10-01 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

journal_title：Annals of the New York Academy of Sciences

authors： Abe Y

更新日期：2006-09-01 00:00:00

abstract：:In the popular and widely used Atkins diet, the body burns fat as its main fuel. This process produces ketosis and hence increased levels of beta-hydroxybutyrate (BOB) acetoacetate (AcAc) and its by-products acetone and acetol. These products are potential precursors of the glycotoxin methylglyoxal. Since methylglyoxa...

journal_title：Annals of the New York Academy of Sciences

authors： Beisswenger BG,Delucia EM,Lapoint N,Sanford RJ,Beisswenger PJ

更新日期：2005-06-01 00:00:00

abstract：:Substantial evidence suggests that stress can alter the general toxicological properties of the substituted amphetamines (AMPs) as well as their psychostimulant properties. Research concerning the interactions between stress and the neurotoxicity associated with the AMPs is, however, limited. Our previous work demonst...

journal_title：Annals of the New York Academy of Sciences

authors： Miller DB,O'Callaghan JP

更新日期：1996-10-31 00:00:00

abstract：:Gene expression regulation, in particular at the level of transcription, has been demonstrated to play a key role in the development of human diseases, including cancer, and in bacteria it is crucial for proliferation as well as for pathogenicity. Transcriptional regulation is based on complex networks of interactions...

journal_title：Annals of the New York Academy of Sciences

authors： Zorrilla S,Lillo MP,Chaix D,Margeat E,Royer CA,Declerck N

更新日期：2008-01-01 00:00:00

abstract：:Visual motion is sensed by low-level (energy-based) and high-level (feature-based) mechanisms. Our interest is in the motion detectors underlying the initial ocular following responses (OFR) that are elicited at ultrashort latencies by sudden motions of large images. OFR were elicited in humans by applying horizontal ...

journal_title：Annals of the New York Academy of Sciences

authors： Chen KJ,Sheliga BM,Fitzgibbon EJ,Miles FA

更新日期：2005-04-01 00:00:00

abstract：:Ginkgo biloba extract EGb 761 has been used for many years to treat age-related cognitive disorders including Alzheimer's disease. EGb 761 given shortly after initiating mitochondrial damage by sodium nitroprusside (nitric oxide donor) improved the mitochondrial membrane potential of PC12 cells significantly and dose ...

journal_title：Annals of the New York Academy of Sciences

authors： Eckert A,Keil U,Scherping I,Hauptmann S,Müller WE

更新日期：2005-11-01 00:00:00

abstract：:In response to infection or effective vaccination, naive antigen-specific CD8+ T cells undergo a dramatic highly orchestrated activation process. Initial encounter with an appropriately activated antigen-presenting cell leads to blastogenesis and an exponential increase in antigen-specific CD8+ T cell numbers. Simulta...

journal_title：Annals of the New York Academy of Sciences

authors： Obar JJ,Lefrançois L

更新日期：2010-01-01 00:00:00

abstract：:These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...

journal_title：Annals of the New York Academy of Sciences

authors： Ferris CF,Brewer J

更新日期：1996-09-20 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of ...

journal_title：Annals of the New York Academy of Sciences

authors： Chen BT,Hopf FW,Bonci A

更新日期：2010-02-01 00:00:00

abstract：:The aim of this study is to identify immune correlates of protection against tuberculosis induced by the current vaccine, Bacille Calmette Guerin (BCG). This knowledge should be valuable for developing and testing novel tuberculosis vaccines. Blood from 5675 10-week-old South African infants, routinely vaccinated with...

journal_title：Annals of the New York Academy of Sciences

authors： Hanekom WA

更新日期：2005-12-01 00:00:00

abstract：:Tick burdens cause direct damage to hosts and transmit several disease agents, the majority of which are secreted into feeding lesions through tick salivary glands. Reduced incidence of naturally transmitted tick-borne diseases was recently observed among cattle immunized with tick salivary gland extracts (TSGE). The ...

journal_title：Annals of the New York Academy of Sciences

authors： Jittapalapong S,Phichitrasilp T,Chanphao H,Rerkamnuychoke W,Stich RW

更新日期：2008-12-01 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:Long-term repopulating hematopoietic stem cells can be separated from cells which provided radioprotection (short-term repopulating cells) on the basis of size. This might be a result of the quiescent nature of long-term repopulating cells. To define the activity of these populations we utilized a dye, PKH26, which in...

journal_title：Annals of the New York Academy of Sciences

authors： Lanzkron SM,Collector MI,Sharkis SJ

更新日期：1999-04-30 00:00:00