Achalasia: what to do in the face of failures of Heller myotomy.

abstract：:The fracture of bone is clearly a major health concern, especially for the elderly. Medical therapies to reduce the possibility of bone fracture to date have principally centered on treating the loss in bone mass (bone mineral density) that accompanies aging (i.e., addressing the loss in bone quantity). However, it is...

journal_title：Annals of the New York Academy of Sciences

authors： Ritchie RO

更新日期：2010-03-01 00:00:00

abstract：:Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...

journal_title：Annals of the New York Academy of Sciences

authors： Gerling IC,Ali C,Lenchik N

更新日期：2003-11-01 00:00:00

abstract：:On the basis of evidence just reviewed, the hormonal requirements during IVM of mammalian oocytes for fertilization and developmental competence may be summarized as follows: 1. Nuclear maturation occurs "spontaneously," without follicular factors or hormones, in all mammalian species. 2. Cumulus cells are necessary d...

journal_title：Annals of the New York Academy of Sciences

authors： Armstrong DT,Zhang X,Vanderhyden BC,Khamsi F

更新日期：1991-01-01 00:00:00

abstract：:Researchers in Utrecht, the Netherlands have studied the effects of different factors, such as oral contraceptives (OCs), on sex hormone binding globulin (SHBG) levels in blood. The SHBG levels in women who continuously used OCs consisting only of .05 mg of ethinyl estradiol (EE2) rose as high as 260% + or - 25% of t...

journal_title：Annals of the New York Academy of Sciences

authors： Thijssen JH

更新日期：1988-01-01 00:00:00

abstract：:Whether T cells promote bone loss following immobilization after spinal cord injury (SCI) remains undetermined. Therefore, wild-type (WT) and T cell-deficient (Tcrb-/- ) male mice underwent sham or contusion SCI to cause hindlimb paralysis. Femurs were isolated and distal and midshaft regions were evaluated by microco...

journal_title：Annals of the New York Academy of Sciences

authors： Sahbani K,Shultz LC,Cardozo CP,Bauman WA,Tawfeek HA

更新日期：2020-10-26 00:00:00

abstract：:Starling's law and the end-systolic pressure-volume relationship (ESPVR) reflect the effect of sarcomere length (SL) on the development of stress (sigma) and shortening by myocytes in the uniform ventricle. We show here that tetanic contractions of rat cardiac trabeculae exhibit a sigma-SL relationship at saturating [...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Shinozaki T,Zhang YM,Wakayama Y,Sugai Y,Kagaya Y,Miura M,Boyden PA,Stuyvers BD,Landesberg A

更新日期：2008-03-01 00:00:00

abstract：:In amphibians, alpha-MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, th...

journal_title：Annals of the New York Academy of Sciences

authors： Vaudry H,Chartrel N,Desrues L,Galas L,Kikuyama S,Mor A,Nicolas P,Tonon MC

更新日期：1999-10-20 00:00:00

abstract：:Judicious selection of new animal models for the study of basic aging processes must combine feasibility and good use of the comparative method with evidence of antiaging adaptations, like the ability to combat oxidative damage to cells and tissues. A number of vertebrate species already in use or being developed as n...

journal_title：Annals of the New York Academy of Sciences

authors： Holmes DJ

更新日期：2004-06-01 00:00:00

abstract：:Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic ph...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HJ,Lee KW,Lee HJ

更新日期：2007-01-01 00:00:00

abstract：:We discussed the bonding of O2 to hemoglobin using results of ab initio calculations of idealized portions of the Hb molecule. The bond between Fe and O2 is formed by coupling a triplet state (intermediate spin state) of Fe to the triplet ground state of O2 (analogous to the bonding of O to O2 in ozone). The coordinat...

journal_title：Annals of the New York Academy of Sciences

authors： Goddard WA 3rd,Olafson BD

更新日期：1981-01-01 00:00:00

abstract：:Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest...

journal_title：Annals of the New York Academy of Sciences

authors： Morara S,Rosina A,Provini L

更新日期：1992-06-30 00:00:00

abstract：:Thalassemia influences individual and family psychosocial functioning. Parental reaction to diagnosis affects the parent-child relationship, parents' roles, and family resources for coping. A child frequently translates parental reactions into personal attitudes of dependency and lowered self-esteem. In coping with on...

journal_title：Annals of the New York Academy of Sciences

authors： Nash KB

更新日期：1990-01-01 00:00:00

abstract：:Although many authors have considered a direct interaction between allergic reactions and behavioral changes, supporting evidence has been elusive. In this series of studies we show that after oral or nasal ovalbumin (OVA) challenge, allergic mice present increased Fos expression in the paraventricular nucleus of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Costa-Pinto FA,Basso AS,De Sá-Rocha LC,Britto LR,Russo M,Palermo-Neto J

更新日期：2006-11-01 00:00:00

abstract：:Regulation of carbohydrate and fat utilization by skeletal muscle at rest and during exercise has been the subject of investigation since the early 1960s when Randle et al. proposed the so-called glucose-fatty acid cycle to explain the reciprocal relationship between carbohydrate and fat metabolism. The suggested mech...

journal_title：Annals of the New York Academy of Sciences

authors： Jeukendrup AE

更新日期：2002-06-01 00:00:00

abstract：:The dynamics and kinematics of saccades in a patient with severe ocular myasthenia were studied before and after treatment with intravenous immunoglobulin (IVIG). Before therapy, horizontal saccades were hypometric, but faster than similar-sized saccades made by normal subjects. During a 5-minute test period, saccades...

journal_title：Annals of the New York Academy of Sciences

authors： Serra A,Thurtell MJ,Leigh RJ

更新日期：2009-05-01 00:00:00

abstract：:Anaplasma marginale and A. phagocytophylum are intracellular rickettsiae that cause bovine anaplasmosis and human granulocytic anaplasmosis, respectively. The ultimate vaccine for the control of anaplasmosis would be one that reduces infection and transmission of the pathogen by ticks. Effective vaccines for control o...

journal_title：Annals of the New York Academy of Sciences

authors： de la Fuente J,Ayoubi P,Blouin EF,Almazán C,Naranjo V,Kocan KM

更新日期：2006-10-01 00:00:00

abstract：:The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

journal_title：Annals of the New York Academy of Sciences

authors： Ghosn EE,Yang Y

更新日期：2015-12-01 00:00:00

abstract：:Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. To transfer this potential to the clinical laboratory, the development and the proper use of standards and calibrators are required to ensure comparability and r...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz A,Fernández-Repollet E

更新日期：1993-03-20 00:00:00

abstract：:The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

journal_title：Annals of the New York Academy of Sciences

authors： Noble D

更新日期：2008-03-01 00:00:00

abstract：:Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and other organs is usually undetectable at primary diagnosis, even by high resolution imaging technologies. However, ultrasensitive approaches now enable the detection of "occult" tumor cells. Many researchers are currently focusin...

journal_title：Annals of the New York Academy of Sciences

authors： Riethdorf S,Pantel K

更新日期：2010-10-01 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:The nearly neutral theory represents a development of Kimura's neutral theory of molecular evolution that makes testable predictions that go beyond a mere null model. Recent evidence has strongly supported several of these predictions, including the prediction that slightly deleterious variants will accumulate in a sp...

journal_title：Annals of the New York Academy of Sciences

authors： Hughes AL

更新日期：2008-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis. Fractalkine, a CX3C/chemokine (CX3CL1), mediates monocytes-macrophage infiltration in activated endothelium, suggesting its specific role in atherosclerosis-related inflammation. In this study, we evaluate the following in early RA patients: the...

journal_title：Annals of the New York Academy of Sciences

authors： Pingiotti E,Cipriani P,Marrelli A,Liakouli V,Fratini S,Penco M,Giacomelli R

更新日期：2007-06-01 00:00:00

abstract：:The last decade has witnessed a surge in studies on steroid hormones of maternal origin present in avian eggs and affecting offspring development. The value of such studies for the understanding of maternal effects and individual differentiation is endorsed and a series of methodological and conceptual issues in the c...

journal_title：Annals of the New York Academy of Sciences

authors： Groothuis TG,von Engelhardt N

更新日期：2005-06-01 00:00:00

abstract：:The initial phase of vessel formation is the establishment of nascent endothelial tubes from mesodermal precursor cells. Development of the vascular epithelium is examined using the transcription factor TAL1 as a marker of endothelial precursor cells (angioblasts), and a functional assay based on intact, whole-mounted...

journal_title：Annals of the New York Academy of Sciences

authors： Drake CJ,Hungerford JE,Little CD

更新日期：1998-10-23 00:00:00

abstract：:In this chapter, we examine the possibility that negative emotions contribute to the relationship between socioeconomic status (SES) and health. A model of the associations among SES, emotion, and health is presented first. We then review the evidence for this model, showing associations of SES with depression, hopele...

journal_title：Annals of the New York Academy of Sciences

authors： Gallo LC,Matthews KA

更新日期：1999-01-01 00:00:00

abstract：:Males and females rarely have identical evolutionary interests over reproduction, and when the fitness of both sexes is dependent upon paternity outcomes, sexual conflict over fertilization is inevitable. In internal fertilizers, the female tract is a formidable selective force on the number and integrity of sperm tha...

journal_title：Annals of the New York Academy of Sciences

authors： Firman RC

更新日期：2018-06-01 00:00:00

abstract：:We have heard a wide-ranging set of talks on cosmology and high energy astrophysics at this conference. All I can really do in this short talk is to present my subjective impression of an arbitrary selection of highlights. ...

journal_title：Annals of the New York Academy of Sciences

authors： Rees MJ

更新日期：1993-06-01 00:00:00

abstract：:Immunoglobulin 4 (IgG4) is one of four human IgG subclasses and has several unique functional characteristics. It exhibits low affinity for complement and for most Fc receptors. It furthermore has generally high affinity for its antigen, with binding occurring in a monovalent fashion, as IgG4 can exchange Fab-arms wit...

journal_title：Annals of the New York Academy of Sciences

authors： Huijbers MG,Plomp JJ,van der Maarel SM,Verschuuren JJ

更新日期：2018-02-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune, polygenic disease, associated with several genes on different chromosomes. The most important gene is human leukocyte antigen (HLA), also known as major histocompatibility complex (MHC), which is located on chro...

journal_title：Annals of the New York Academy of Sciences

authors： Shtauvere-Brameus A,Ghaderi M,Rumba I,Sanjeevi CB

更新日期：2002-04-01 00:00:00