Absence of αβ T cells accelerates disuse bone loss in male mice after spinal cord injury.

Abstract:

:Whether T cells promote bone loss following immobilization after spinal cord injury (SCI) remains undetermined. Therefore, wild-type (WT) and T cell-deficient (Tcrb-/- ) male mice underwent sham or contusion SCI to cause hindlimb paralysis. Femurs were isolated and distal and midshaft regions were evaluated by microcomputed tomography scanning. Bone marrow (BM) levels of bone turnover markers, as well as receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG), were measured by ELISA. At 2 weeks post-SCI, immobilization resulted in marked reduction in trabecular fractional bone volume (55%), thickness (40%), connectivity, and cortical thickness only in the Tcrb-/- animals (interaction with P < 0.05). BM analysis revealed lower bone formation (procollagen type 1 intact N-terminal propeptide), higher bone resorption (tartrate-resistant acid phosphatase-5b), and a higher RANKL/OPG ratio in the Tcrb-/- SCI animals. At 5 weeks post-SCI, while both WT and Tcrb-/- paralyzed animals showed deterioration of all indices of bone structure, they were more severe in Tcrb-/- animals. In summary, unlike other skeletal disorders, loss of αβ T cells compromises, rather than preserves, skeletal integrity under conditions of immobilization.

journal_name

Ann N Y Acad Sci

authors

Sahbani K,Shultz LC,Cardozo CP,Bauman WA,Tawfeek HA

doi

10.1111/nyas.14518

subject

Has Abstract

pub_date

2020-10-26 00:00:00

eissn

0077-8923

issn

1749-6632

pub_type

杂志文章
  • Development of clinical standards for flow cytometry.

    abstract::Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. To transfer this potential to the clinical laboratory, the development and the proper use of standards and calibrators are required to ensure comparability and r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb38760.x

    authors: Schwartz A,Fernández-Repollet E

    更新日期:1993-03-20 00:00:00

  • Differential effects of donepezil on methamphetamine and cocaine dependencies.

    abstract::Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine-conditioned place preference (CPP) and locomotor sensitization to cocaine. In the present study, we investigat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1369.042

    authors: Takamatsu Y,Yamanishi Y,Hagino Y,Yamamoto H,Ikeda K

    更新日期:2006-08-01 00:00:00

  • Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.

    abstract::We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While the mechanism of this protection has largely been thought to be due to their chaperone functions (i.e., preventing abnormal pro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1344.007

    authors: Yenari MA,Liu J,Zheng Z,Vexler ZS,Lee JE,Giffard RG

    更新日期:2005-08-01 00:00:00

  • Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids.

    abstract::Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05621.x

    authors: Kaipparettu BA,Ma Y,Wong LJ

    更新日期:2010-07-01 00:00:00

  • Acid-base interactions during exocrine pancreatic secretion. Primary role for ductal bicarbonate in acinar lumen function.

    abstract::The role of acid-base interactions during coordinated acinar and duct cell secretion in the exocrine pancreas is described. The sequence of acid-base events may be summarized as follows: (1) Sorting of secretory proteins and membrane components into the regulated secretory pathway of pancreatic acinar cells is trigger...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb44066.x

    authors: Freedman SD,Scheele GA

    更新日期:1994-03-23 00:00:00

  • Tuberculosis drug discovery and emerging targets.

    abstract::Current tuberculosis (TB) therapies take too long and the regimens are complex and subject to adverse effects and drug-drug interactions with concomitant medications. The emergence of drug-resistant TB strains exacerbates the situation. Drug discovery for TB has resurged in recent years, generating compounds (hits) wi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12459

    authors: Mdluli K,Kaneko T,Upton A

    更新日期:2014-09-01 00:00:00

  • Early precancerous modifications in the mucus of human and rat distal colon: a comparative immunohistologic study.

    abstract::The M1 antigens, associated with gastric fucomucin, the early oncofetal precancerous marker for the distal colon, were studied using the immunoperoxidase method in the distal colon. We compared human tumoral mucosa with that of rats during DMH-induced carcinogenesis. In both cases we examined histologically normal muc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb32862.x

    authors: Bara J,Decaens C,Burtin P

    更新日期:1983-01-01 00:00:00

  • Antihypertensive compounds that modulate the Na-K pump.

    abstract::A primary impairment of the kidney sodium excretion has been documented both in hypertensive patients (EH) and genetic animal models (Milan hypertensive rat [MHS]) carrying mutations of the cytoskeletal protein adducin and/or increased plasma levels of endogenous ouabain (EO). Ouabain (OU) itself induces hypertension ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07284.x

    authors: Ferrari P,Ferrandi M,Torielli L,Barassi P,Tripodi G,Minotti E,Molinari I,Melloni P,Bianchi G

    更新日期:2003-04-01 00:00:00

  • A method for characterization of total circulating DNA.

    abstract::Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1448.031

    authors: van der Vaart M,Pretorius PJ

    更新日期:2008-08-01 00:00:00

  • Influence of mycoplasma contamination on the concentration and composition of extracellular RNA.

    abstract::Kinetics of extracellular RNA accumulation in culture medium and at the cell surface along with their composition and distribution among cell-free and cell-surface-bound fractions were investigated in mycoplasma-contaminated and mycoplasma-free HeLa cells. It was shown that the mycoplasma infection influenced the conc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1368.046

    authors: Morozkin ES,Rykova EY,Vlassov VV,Laktionov PP

    更新日期:2006-09-01 00:00:00

  • Immunomodulatory roles of the carcinoembryonic antigen family of glycoproteins.

    abstract::One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1326.037

    authors: Shao L,Allez M,Park MS,Mayer L

    更新日期:2006-08-01 00:00:00

  • Interaction of ascorbate and alpha-tocopherol.

    abstract::Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb23761.x

    authors: Niki E

    更新日期:1987-01-01 00:00:00

  • Human dendritic cells subsets as targets and vectors for therapy.

    abstract::The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12113

    authors: Klechevsky E,Banchereau J

    更新日期:2013-05-01 00:00:00

  • Deficient protein kinase a in systemic lupus erythematosus: a disorder of T lymphocyte signal transduction.

    abstract::Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease characterized by impaired T lymphocyte immune effector functions. We have identified a disorder of signal transduction in SLE T cells involving the cyclic AMP/protein kinase A (cAMP/PKA) pathway. Cyclic AMP-stimulated PKA-catalyzed protein phosphor...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04329.x

    authors: Kammer GM

    更新日期:2002-06-01 00:00:00

  • IgG4-mediated autoimmune diseases: a niche of antibody-mediated disorders.

    abstract::Immunoglobulin 4 (IgG4) is one of four human IgG subclasses and has several unique functional characteristics. It exhibits low affinity for complement and for most Fc receptors. It furthermore has generally high affinity for its antigen, with binding occurring in a monovalent fashion, as IgG4 can exchange Fab-arms wit...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13561

    authors: Huijbers MG,Plomp JJ,van der Maarel SM,Verschuuren JJ

    更新日期:2018-02-01 00:00:00

  • On assessment of skin reactivity using electrical impedance.

    abstract::Pathophysiological events in biological tissue are characterized by a shift in electrical impedance spectra of the tissue under study. In this paper, techniques based on electrical impedance are reviewed with emphasis on their possible role in evaluating the skin reactivity of an individual, including results from imp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb09469.x

    authors: Nyrén M,Hagströmer L,Emtestam L

    更新日期:1999-04-20 00:00:00

  • Multi-scale model of O2 transport and metabolism: response to exercise.

    abstract::Regulation of pulmonary oxygen uptake (VO2p) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.021

    authors: Zhou H,Lai N,Saidel GM,Cabrera ME

    更新日期:2008-03-01 00:00:00

  • Processing of precursor proteins by preparations of oviduct microsomes.

    abstract::The signal peptidases from both chicken oviduct and dog pancreas microsomes have been detected by a post-translational assay and, in the case of dog microsomes, by a cotranslational assay. This proteolytic activity is not sensitive to a variety of conventional protease inhibitors under the conditions used in these ass...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb47251.x

    authors: Thibodeau SN,Walsh KA

    更新日期:1980-01-01 00:00:00

  • Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats.

    abstract::The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb51860.x

    authors: Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

    更新日期:1997-09-20 00:00:00

  • Severe hyperthyroidism without symptoms due to nonthyroidal illness in a child with acute hepatitis: case report and literature review.

    abstract::While liver enzyme changes are frequently reported in hyperthyroidism, liver dysfunction itself can lead to alterations in thyroid hormone metabolism. However, the exact relationship between hyperthyroidism and liver dysfunction is unclear. We report an 11-year-old boy presenting with acute hepatitis of unknown etiolo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14493

    authors: Yeliosof O,Marshall I

    更新日期:2020-09-23 00:00:00

  • Are rapists differentially aroused by coercive sex in phallometric assessments?

    abstract::In this chapter we examine whether rapists are sexually aroused by coercive, nonconsensual sex. This question is theoretically important because it speaks to a potential sexual motivation underlying rape. It is also clinically important in that it may reveal an important assessment and treatment target. We first revis...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07307.x

    authors: Lalumière ML,Quinsey VL,Harris GT,Rice ME,Trautrimas C

    更新日期:2003-06-01 00:00:00

  • Phase space transport in noisy Hamiltonian systems.

    abstract::This paper analyzes the effect of low amplitude friction and noise in accelerating phase space transport in time-independent Hamiltonian systems that exhibit global stochasticity. Numerical experiments reveal that even very weak non-Hamiltonian perturbations can dramatically increase the rate at which an ensemble of o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11267.x

    authors: Kandrup HE

    更新日期:1998-12-30 00:00:00

  • Evidence of infection in humans with Rickettsia typhi and Rickettsia felis in Catalonia in the Northeast of Spain.

    abstract::Murine typhus is a cause of fever of intermediate duration in the south of Spain, where antibodies against Rickettsia typhi and Rickettsia felis were observed in humans. This study presents the first report from the northeast of Spain. Human serum samples were tested by serological test. R. typhi and R. felis seroprev...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1374.028

    authors: Nogueras MM,Cardeñosa N,Sanfeliu I,Muñoz T,Font B,Segura F

    更新日期:2006-10-01 00:00:00

  • Xenobiotic-induced recruitment of autoantigens to nuclear proteasomes suggests a role for altered antigen processing in scleroderma.

    abstract::The cell nucleus is a prominent target of autoantibodies in systemic autoimmune disorders. Approximately 2% of the population in Europe and North America suffers from systemic rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and scleroderma. The molecular mechanisms of systemic aut...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1361.080

    authors: Chen M,von Mikecz A

    更新日期:2005-06-01 00:00:00

  • Tumor necrosis factor family receptors regulating bone turnover: new observations in osteoblastic and osteoclastic cell lines.

    abstract::While the tumor necrosis factor (TNF) family members RANKL and TNF-alpha are critical regulators of osteoclast formation, functions of other TNFs in bone are poorly understood. Here we consider the roles in regulating bone turnover of TNF receptors (TNF-R) also expressed by osteoblasts and osteoblast precursors. TNF r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1402.025

    authors: Robinson LJ,Borysenko CW,Blair HC

    更新日期:2007-11-01 00:00:00

  • Amygdala automaticity in emotional processing.

    abstract::The question addressed in this paper is whether the human amygdala processes threat-related stimuli independent of selective attention. This is considered from a functional neuroimaging perspective, describing studies in normal volunteers and patients with brain lesions. The conclusion is that the evidence for such au...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07093.x

    authors: Dolan RJ,Vuilleumier P

    更新日期:2003-04-01 00:00:00

  • Current status of immunotherapies for addiction.

    abstract::The treatment of substance use disorders has always been challenging because multiple neurotransmitters mediate addiction. However, with smoking being the leading cause of preventable death and the recent opioid epidemic in the United States, the search for novel solutions becomes more imperative. In this review, we d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14329

    authors: Xu A,Kosten TR

    更新日期:2020-03-08 00:00:00

  • C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies.

    abstract::Recent findings indicate that complement activation--involving specifically C3 and C5--contributes to antiphospholipid (aPL)-mediated thrombosis. Two complement effector pathways are initiated by the cleavage of C5, C5a and C5b, which leads to the formation of the C5b-9 membrane attack complex. To delineate and distin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1422.058

    authors: Romay-Penabad Z,Liu XX,Montiel-Manzano G,Papalardo De Martínez E,Pierangeli SS

    更新日期:2007-06-01 00:00:00

  • Hematopoietic stem cell-independent B-1a lineage.

    abstract::The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12881

    authors: Ghosn EE,Yang Y

    更新日期:2015-12-01 00:00:00

  • Atrial fibrillation, stroke, and quality of life.

    abstract::Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06494.x

    authors: Chinitz JS,Castellano JM,Kovacic JC,Fuster V

    更新日期:2012-04-01 00:00:00