Abstract:
:Approximately 90% of all cancer deaths arise from metastasis formation. Hence, understanding the molecular mechanisms underlying tumor progression, local invasion, and the formation of tumor metastases represents one of the great challenges in exploratory cancer research. Recent experimental results indicate that changes in cell adhesion play a critical role in tumor progression. Cell adhesion molecules of varying classes and functions, including cadherins, cell adhesion molecules of the immunoglobulin family (Ig-CAMs), CD44, and integrins, can interact with and modulate the signaling function of receptor tyrosine kinases (RTKs). Conversely, signaling by RTKs can directly affect the adhesive function of adhesion molecules. Loss of E-cadherin and gain of mesenchymal cadherin function as well as changes in the expression of Ig-CAMs during the progression of many cancer types exemplify such functional implicatons: cell adhesion molecules not only define a tumor cell's adhesive repertoire, but also directly influence classic signal transduction pathways, thereby modulating the metastatic behavior of tumor cells.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Cavallaro U,Christofori Gdoi
10.1196/annals.1294.006subject
Has Abstractpub_date
2004-04-01 00:00:00pages
58-66eissn
0077-8923issn
1749-6632journal_volume
1014pub_type
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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