Translocation of imperiled species under changing climates.

abstract：:Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type 5 17beta-HSD) reduces Delta(4)-androstene-3,17...

journal_title：Annals of the New York Academy of Sciences

authors： Penning TM,Byrns MC

更新日期：2009-02-01 00:00:00

abstract：:In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread ...

journal_title：Annals of the New York Academy of Sciences

authors： Granger DA,Kivlighan KT,el-Sheikh M,Gordis EB,Stroud LR

更新日期：2007-03-01 00:00:00

abstract：:Effective emotion regulation may promote resilience and preschool classroom adjustment by supporting adaptive peer interactions and engagement in learning activities. We investigated how hypothalamus-pituitary-adrenal axis (HPA) regulation, cardiac reactivity, and classroom emotion displays related to adjustment among...

journal_title：Annals of the New York Academy of Sciences

authors： Miller AL,Seifer R,Stroud L,Sheinkopf SJ,Dickstein S

更新日期：2006-12-01 00:00:00

abstract：:Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of ca...

journal_title：Annals of the New York Academy of Sciences

authors： Ganesan K,Xu B

更新日期：2017-08-01 00:00:00

abstract：:Patient privacy is one of the major issues in the development of modern clinical information system networks. Such networks will have to demonstrate an appropriate concern for privacy as a precondition of operation. Regulatory effectiveness analysis is a novel technique for measuring compliance with a technological re...

journal_title：Annals of the New York Academy of Sciences

authors： Brannigan VM

更新日期：1992-12-17 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of the neuromuscular synapse. About half of LEMS patients have an associated small cell lung carcinoma (SCLC), which is usually detected after diagnosis of LEMS. This short review summarizes clinical and serological markers shown to predict the presenc...

journal_title：Annals of the New York Academy of Sciences

authors： Lipka AF,Verschuuren JJ,Titulaer MJ

更新日期：2012-12-01 00:00:00

abstract：:Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As t...

journal_title：Annals of the New York Academy of Sciences

authors： Chinitz JS,Castellano JM,Kovacic JC,Fuster V

更新日期：2012-04-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...

journal_title：Annals of the New York Academy of Sciences

authors： Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

更新日期：2006-07-01 00:00:00

abstract：:In electrical impedance cardiography, Kubicek's formula is often used to measure stroke volume from thoracic impedance variations synchronously to heart activity. To calculate stroke volume from impedance variations, the so-called outflow problem should be adequately solved. This outflow problem refers to the joint ca...

journal_title：Annals of the New York Academy of Sciences

authors： Faes TJ,Raaijmakers E,Meijer JH,Goovaerts HG,Heethaar RM

更新日期：1999-04-20 00:00:00

abstract：:The adrenergic system has long been known to be activated in a situation of stress and thus during opiate withdrawal. A method for detoxification that decreases the stimulation of the sympathetic nervous system will prevent changes of catecholamine levels. Some of such methods have been developed. One of them uses dir...

journal_title：Annals of the New York Academy of Sciences

authors： Macedo TR,Relvas J,Fontes Ribeiro CA,Pacheco F,Morgadinho MT,Pinto CM,Gomes PC,Ventura M,Henriques V,Nunes SV,Ruis GR,Ramalheira C,Boto I,Vale LL

更新日期：2000-09-01 00:00:00

abstract：:Most of the plasma suppressive activity was associated with alpha 2M in both normal subjects and cancer patients. alpha 2M binding to physiological levels of proteases was associated with an increase in the ability to suppress lymphocyte reactivity in the TEEM test. alpha 2M binding to proteases released a peptide tha...

journal_title：Annals of the New York Academy of Sciences

authors： Alomran A,Shenton BK,Donnelly PK,Francis DM,Proud G,Taylor RM

更新日期：1983-01-01 00:00:00

abstract：:The results of a series of experiments aimed at directly comparing the prosodic level of processing in language with the melodic level of processing in music are reported. The first series of experiments was conducted on adults, musicians and nonmusicians, and the second one on 7- to 9-year-old musician and nonmusicia...

journal_title：Annals of the New York Academy of Sciences

authors： Magne C,Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:This study explores the mechanisms dominating the regulation of the biochemical energy consumption and the mechanical output of the actin-myosin motor units, the crossbridges (Xbs), in the cardiac sarcomere. Our analytical model, which couples Xbs cycling dynamics with the kinetics of the free Ca(2+) binding to tropon...

journal_title：Annals of the New York Academy of Sciences

authors： Landesberg A,Levy C,Yaniv Y,Sideman S

更新日期：2004-05-01 00:00:00

abstract：:Cerebrovascular deposition of amyloid is a frequent observation in Alzheimer's disease patients. It can also be detected sporadically in normal aged individuals and is further found in familial diseases linked to specific gene mutations. The source and mechanism of this pathology are still unknown. It has been suggest...

journal_title：Annals of the New York Academy of Sciences

authors： Burgermeister P,Calhoun ME,Winkler DT,Jucker M

更新日期：2000-04-01 00:00:00

abstract：:Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

journal_title：Annals of the New York Academy of Sciences

authors： Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

更新日期：2012-06-01 00:00:00

abstract：:Many cytoplasmic vesicles are observed to move along microtubules. Often, bidirectional movement of particles is observed on a single microtubule. We have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus an...

journal_title：Annals of the New York Academy of Sciences

authors： Sheetz MP,Vale R,Schnapp B,Schroer T,Reese T

更新日期：1987-01-01 00:00:00

abstract：:To summarize (Fig. 10), the structural consequences of monocular deprivation include the following changes: the relay cells in the binocular segments of the deprived geniculate layers shrink and contain less of the possible neurotransmitter NAAG. These changes appear to be secondary to a loss of terminal synaptic arbo...

journal_title：Annals of the New York Academy of Sciences

authors： Tieman SB

更新日期：1991-01-01 00:00:00

abstract：:Our recent work shows that in addition to pumping ions, Na/K-ATPase acts as a signal transducer. Binding of ouabain to Na/K-ATPase changes the interaction of the enzyme with neighboring membrane proteins and induces the formation of multiple signaling modules, resulting in activation of Src, transactivation of the EGF...

journal_title：Annals of the New York Academy of Sciences

authors： Xie Z

更新日期：2003-04-01 00:00:00

abstract：:Gene therapy as an immunomodulatory approach has the potential to treat various inherited and acquired immune-based human diseases. However, its clinical application has several challenges, varying from the efficiency of gene transfer, control of gene expression, cell and tissue targeting, and safety concerns associat...

journal_title：Annals of the New York Academy of Sciences

authors： Singh NP,Yolcu ES,Askenasy N,Shirwan H

更新日期：2005-11-01 00:00:00

abstract：:To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were amino...

journal_title：Annals of the New York Academy of Sciences

authors： Huang MJ,Regunathan S,Botta M,Lee K,McClendon E,Yi GB,Pedersen ML,Berkowitz DB,Wang G,Travagli M,Piletz JE

更新日期：2003-12-01 00:00:00

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:A lactocrine mechanism for delivery of maternally derived relaxin (RLX) into the neonatal circulation as a consequence of nursing has been proposed for the pig. Consistently, immunoreactive porcine RLX was detected in colostrum as well as in the serum of nursing pigs. Concentrations of porcine RLX in milk are highest ...

journal_title：Annals of the New York Academy of Sciences

authors： Frankshun AL,Ho TY,Steinetz BG,Bartol FF,Bagnell CA

更新日期：2009-04-01 00:00:00

abstract：:A variety of different isoforms of mammalian voltage-gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart. All of these channels have been expressed in exogenous systems, and all o...

journal_title：Annals of the New York Academy of Sciences

authors： Goldin AL

更新日期：1999-04-30 00:00:00

abstract：:Aging is the outcome of the contest between chemistry and biology in living systems. Chronic, cumulative chemical modifications compromise the structure and function of biomolecules throughout the body. Proteins with long life spans serve as cumulators of exposure to chemical damage, which is detectable in the form of...

journal_title：Annals of the New York Academy of Sciences

authors： Baynes JW

更新日期：2002-04-01 00:00:00

abstract：:The number of physiologic and metabolic phenomena amenable to analysis using magnetic resonance (MR) techniques is increasing every year. MR techniques can now evaluate tissue parameters relevant to TCA cyclemetabolism, anerobic glycolysis, ATP levels, blood-brain barrier permeability, macrophage infiltration, cytotox...

journal_title：Annals of the New York Academy of Sciences

authors： Jenkins BG,Chen YI,Kuestermann E,Makris NM,Nguyen TV,Kraft E,Brownell AL,Rosas HD,Kennedy DN,Rosen BR,Koroshetz WJ,Beal MF

更新日期：1999-01-01 00:00:00

abstract：:Malignancies have developed several strategies to evade immune surveillance. We have investigated pancreatic cancer cell lines and pancreatic cancer surgical specimens to evaluate possibilities of tumor escape in the Fas system, and local immune suppression. Despite Fas expression the majority of cell lines was resist...

journal_title：Annals of the New York Academy of Sciences

authors： Ungefroren H,Voss M,Bernstorff WV,Schmid A,Kremer B,Kalthoff H

更新日期：1999-06-30 00:00:00

abstract：:Especially since the (re-)discovery of T cell subpopulations with specialized regulatory activities, mechanisms of anti-inflammatory T cell regulation are studied very actively and are expected to lead to the development of novel immunotherapeutic approaches, especially in chronic inflammatory diseases. Heat shock pro...

journal_title：Annals of the New York Academy of Sciences

authors： Van Eden W,Wick G,Albani S,Cohen I

更新日期：2007-10-01 00:00:00

abstract：:After fertilization, the next major hurdle for human reproduction is trophoblast differentiation, which is required for implantation, followed in lockstep by rapid assembly of these embryonic cells into a functional placenta. During this process, cytotrophoblast stem cells invade the uterus, anchoring the conceptus to...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou Y,Genbacev O,Fisher SJ

更新日期：2003-05-01 00:00:00

abstract：:Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...

journal_title：Annals of the New York Academy of Sciences

authors： Manheimer-Lory A,Irigoyen M,Gaynor B,Monhian R,Splaver A,Diamond B

更新日期：1995-09-29 00:00:00