Catecholaminergic pathways, chromaffin cells, and human disease.

Abstract:

:Recent studies demonstrate major effects of adrenal medullary and catecholaminergic pathways on a wide variety of normal physiologic and regulatory events. Alterations in these pathways, involving changes in catecholamines or in proteins and peptides costored and coreleased with catecholamines, may lead to profound changes in autonomic, cardiovascular, neuroendocrine, metabolic, nociceptive, and immune function. These findings have important implications for a variety of human disease states. In addition, molecules associated with catecholaminergic function may provide novel diagnostic and therapeutic strategies for human disease and suggest specific genetic loci as important and fruitful targets for further genetic and pharmacogenetic studies.

journal_name

Ann N Y Acad Sci

authors

Parmer RJ,Zinder O

doi

10.1111/j.1749-6632.2002.tb04514.x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

497-505

eissn

0077-8923

issn

1749-6632

journal_volume

971

pub_type

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