Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications.

Abstract:

:The clinical significance of lymphocytic esophagitis (LyE), which is characterized by the prominence of peripapillary intraepithelial lymphocytes (IELs) without significant granulocytosis, remains poorly understood. During the last few years, plausible clinical correlates and novel approaches for stratification of LyE have started to emerge. Association with Crohn's disease has been established in children, but is not observed in adults. In adults, the form of LyE showing CD4+ -predominant IELs has been recently found to be associated with non-achalasia primary motility abnormalities. GERD is another possible association. The most common clinical manifestations of adult LyE are dysphagia and normal endoscopic appearance of the esophagus. LyE should be reported by pathologists in order to distinguish it from its mimics, such as eosinophilic esophagitis, and to assist in directing the next steps in evaluation for known associated diseases, such as Crohn's disease or motility disorders.

journal_name

Ann N Y Acad Sci

authors

Lisovsky M,Westerhoff M,Zhang X

doi

10.1111/nyas.13260

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

133-138

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1381

pub_type

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