Peripheral factors in the metabolic syndrome: the pivotal role of adiponectin.

abstract：:Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Reifsnyder PC,Ryzhov S,Flurkey K,Anunciado-Koza RP,Mills I,Harrison DE,Koza RA

更新日期：2018-04-01 00:00:00

abstract：:Septic shock is a systemic response to severe bacterial infections, generally caused by Gram-negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi-organ failure. All these effects, are induced by the generation of pro-inflammat...

journal_title：Annals of the New York Academy of Sciences

authors： Martínez C,Arranz A,Juarranz Y,Abad C,García-Gómez M,Rosignoli F,Leceta J,Gomariz RP

更新日期：2006-07-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative process characterized by progressive degeneration of the substantia nigra and concurrent loss of neuromelanin in these structures. The present hypothesis suggests that progression of Parkinson's disease may be reduced by enhancing the regional levels of neuroprotective factor...

journal_title：Annals of the New York Academy of Sciences

authors： Halabe Bucay A

更新日期：2008-11-01 00:00:00

abstract：:Drug addiction is a chronic relapsing brain disorder characterized by neurobiological changes that lead to a compulsion to take a drug with loss of control over drug intake. The hypothesis outlined here is that knowledge of the neurochemical systems involved in the transition from drug use to the compulsive use of add...

journal_title：Annals of the New York Academy of Sciences

authors： Koob GF

更新日期：2000-01-01 00:00:00

abstract：:The anesthetic effect of certain steroids in vertebrate systems is well documented, but it is not known if these compounds can cause anesthesia in simpler organisms. To answer this question, ether, short-chain alkanols, and pregnanolone were tested for their ability to induce anesthesia in 20 aquatic species from 7 ph...

journal_title：Annals of the New York Academy of Sciences

authors： Oliver AE,Deamer DW,Akeson M

更新日期：1991-01-01 00:00:00

abstract：:At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at lea...

journal_title：Annals of the New York Academy of Sciences

authors： Berger MR,Tsoneva I,Konstantinov SM,Eibl H

更新日期：2003-12-01 00:00:00

abstract：:Policy and program implementers require evidence on whether integrated psychosocial stimulation and nutrition interventions can be effectively delivered at-scale, how, and at what cost? To address some of these issues, a comprehensive evaluation of implementation was designed for a trial in Pakistan that integrated ps...

journal_title：Annals of the New York Academy of Sciences

authors： Yousafzai AK,Rasheed MA,Siyal S

更新日期：2018-05-01 00:00:00

abstract：:The essential trace element selenium is of fundamental importance to human biology. Information on the membrane-bound selenoproteins was obtained by labeling of rats in vivo with (75)Se-selenite, subcellular fractionation of the tissue homogenates, separation of the proteins by SDS-PAGE, two-dimensional electrophoresi...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bertelsmann H,Graebert A,Hoppe B,Kuhbacher M,Behne D

更新日期：2002-11-01 00:00:00

abstract：:We report here the two first cases of human ehrlichiosis described in Italy. One patient presented symptoms indicative of ehrlichiosis, such as fever, conjunctivitis, and increase of hepatic enzymes; HGE was confirmed by fourfold seroconversion for HGE antigen. The second patient, a forest worker, was affected by Lyme...

journal_title：Annals of the New York Academy of Sciences

authors： Ruscio M,Cinco M

更新日期：2003-06-01 00:00:00

abstract：:A beneficial effect of dimethyl sulfoxide (DMSO) in the treatment of acute focal cerebral ischemia has not been proven. In the present study, two established experimental models of acute focal cerebral ischemia were treated with DMSO. Twenty adult cats lightly anesthetized with ketamine hydrochloride underwent right m...

journal_title：Annals of the New York Academy of Sciences

authors： Little JR,Spetzler RF,Roski RA,Selman WR,Zabramski J,Lesser RP

更新日期：1983-01-01 00:00:00

abstract：:We have presented a perspective of progress in three areas of simulations of complex molecules: the development of force fields for molecular simulation; the application of computer graphics, molecular mechanics and molecular dynamics in simulations of DNA and DNA-drug complexes and the application of computer graphic...

journal_title：Annals of the New York Academy of Sciences

authors： Kollman PA,Weiner S,Seibel G,Lybrand T,Singh UC,Caldwell J,Rao SN

更新日期：1986-01-01 00:00:00

abstract：:CYP21A2 genotyping remains an important element in the diagnosis and management of congenital adrenal hyperplasia, and establishing accurate genotype-phenotype correlations has facillitated adequate genetic counseling and prenatal management for at-risk families. Despite extensive efforts to establish a clear genotype...

journal_title：Annals of the New York Academy of Sciences

authors： Elmougy F,Sharaf S,Hafez M,Khattab A,Abou-Yousef H,Elsharkawy M,Baz H,Ekladious S,Sherif B,Musa N,Elshiwy Y,Afif A,Abdullatif M,Thabet G,Rady N,Ibrahim A,Soliman H

更新日期：2018-03-01 00:00:00

abstract：:Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone. However, the mechanisms that control the differentiation of osteoblasts into osteocytes embedded in bone matrix are not well understood. With the recent developments of transgenic models for manipulating gene expression in osteocytes an...

journal_title：Annals of the New York Academy of Sciences

authors： Dallas SL,Bonewald LF

更新日期：2010-03-01 00:00:00

abstract：:This paper is a progress report on our present understanding of iron nutrition in man, particularly in developing countries. We will be concerned with the quantitative aspects of iron balance and in particular with the availability of dietary iron, the recognition of iron deficiency and its prevalence, the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Finch CA

更新日期：1977-11-30 00:00:00

abstract：:Accumulating evidence indicates that regulatory T cells play a crucial role in preventing autoimmunity. To examine the processes by which regulatory CD4(+) T cells are produced during immune repertoire formation, we have developed transgenic mice that express the influenza virus hemagglutinin (HA) and coexpress major ...

journal_title：Annals of the New York Academy of Sciences

authors： Caton AJ,Cozzo C,Larkin J 3rd,Lerman MA,Boesteanu A,Jordan MS

更新日期：2004-12-01 00:00:00

abstract：:Access to experimental X-ray diffraction image data is important for validation and reproduction of macromolecular models and indispensable for the development of structural biology processing methods. In response to the evolving needs of the structural biology community, we recently established a diffraction data pub...

journal_title：Annals of the New York Academy of Sciences

authors： McKinney B,Meyer PA,Crosas M,Sliz P

更新日期：2017-01-01 00:00:00

abstract：:Like many other transcription factors, the tumor suppressor protein p53 is bound to the nuclear matrix (NM). To study the interaction of p53 with the NM in more detail, we used alkaline and acidic extractions of NM proteins. It was found that there are two forms of p53, alkali- and acid-soluble, in NM of HEK293 cells ...

journal_title：Annals of the New York Academy of Sciences

authors： Lapshina MA,Parkhomenko II,Terentiev AA

更新日期：2006-12-01 00:00:00

abstract：:The arterial baroreflex has two important functions. First, the arterial baroreflex is a negative feedback reflex that regulates arterial pressure around a preset value called a set or operating point. Second, the arterial baroreflex also establishes the prevailing systemic arterial pressure when the operating point i...

journal_title：Annals of the New York Academy of Sciences

authors： DiCarlo SE,Bishop VS

更新日期：2001-06-01 00:00:00

abstract：:This paper reports CFD-simulations of the turbulent flow, pressure loss and heat transfer occurring in ribbed passages. The channel section is rectangular, with an aspect ratio of 2.04. Ribs are square cross-section, their height is 10% of the channel height, and their inclination is varied from 90 degrees to 33 degre...

journal_title：Annals of the New York Academy of Sciences

authors： Hermanson K,Parneix S,von Wolfersdorf J,Semmler K

更新日期：2001-05-01 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:Birds, the most species-rich monophyletic group of land vertebrates, have been subject to some of the most intense sequencing efforts to date, making them an ideal case study for recent developments in genomics research. Here, we review how our understanding of bird genomes has changed with the recent sequencing of mo...

journal_title：Annals of the New York Academy of Sciences

authors： Kapusta A,Suh A

更新日期：2017-02-01 00:00:00

abstract：:The aim of our work was to detect minor loci acting as Alzheimer's disease (AD) genetic markers. We divided 206 AD patients and 186 individuals as controls into six age at onset/age-dependent groups. We studied polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, ...

journal_title：Annals of the New York Academy of Sciences

authors： Beyer K,Lao JI,Latorre P,Ariza A

更新日期：2005-12-01 00:00:00

abstract：:We recently isolated a novel bHLH/PAS protein, CLIF (cycle like factor), by yeast two-hybrid screening of human umbilical endothelial cell cDNA library. CLIF is preferentially expressed in endothelial and neuronal cells. Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK, the ke...

journal_title：Annals of the New York Academy of Sciences

authors： Maemura K,Layne MD,Watanabe M,Perrell MA,Nagai R,Lee ME

更新日期：2001-12-01 00:00:00

abstract：:Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo...

journal_title：Annals of the New York Academy of Sciences

authors： Hatting M,Tavares CDJ,Sharabi K,Rines AK,Puigserver P

更新日期：2018-01-01 00:00:00

abstract：:Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s,...

journal_title：Annals of the New York Academy of Sciences

authors： Harbuz MS,Chover-Gonzalez AJ,Jessop DS

更新日期：2003-05-01 00:00:00

abstract：:New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL...

journal_title：Annals of the New York Academy of Sciences

authors： Paré D,Royer S,Smith Y,Lang EJ

更新日期：2003-04-01 00:00:00

abstract：:Sleep deprivation severely compromises the ability of human beings to respond to stimuli in a timely fashion. These deficits have been attributed in large part to failures of vigilant attention, which many theorists believe forms the bedrock of the other more complex components of cognition. One of the leading paradig...

journal_title：Annals of the New York Academy of Sciences

authors： Lim J,Dinges DF

更新日期：2008-01-01 00:00:00

abstract：:Choir singing is positively associated with well-being and quality of life, and requires the coordination of physiological systems within and across individuals. Informed by models of interpersonal action coordination, we delineate the network topography of choir singing by analyzing cross-frequency couplings and with...

journal_title：Annals of the New York Academy of Sciences

authors： Müller V,Delius JAM,Lindenberger U

更新日期：2018-11-01 00:00:00

abstract：:It is believed that HDL exerts its anti-atherogenic effects through the process of delivering cholesterol from peripheral tissues back to the liver for removal from the body (i.e., reverse cholesterol transport). The metabolic life cycle of HDL lipid and apolipoproteins during reverse cholesterol transport involves bo...

journal_title：Annals of the New York Academy of Sciences

authors： Silver DL,Jiang XC,Arai T,Bruce C,Tall AR

更新日期：2000-05-01 00:00:00