Soluble HLA class I and class II molecules in relapsing-remitting multiple sclerosis: acute response to interferon-beta1a treatment and their use as markers of disease activity.

abstract：:Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell-to-cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the dige...

journal_title：Annals of the New York Academy of Sciences

authors： Hamzaoui N,Pringault E

更新日期：1998-11-17 00:00:00

abstract：:An MRI-pathological correlation study was performed to determine the pathological background of white matter lesions depicted on MR images. The pathological findings were various combinations of myelin loss, axonal loss, scattered microinfarcts, astrogliosis, dilatation of perivascular space, and relative preservation...

journal_title：Annals of the New York Academy of Sciences

authors： Udaka F,Sawada H,Kameyama M

更新日期：2002-11-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of typ...

journal_title：Annals of the New York Academy of Sciences

authors： Lande R,Gilliet M

更新日期：2010-01-01 00:00:00

abstract：:The possible role of the cerebellum for the control of saccades and gaze holding is reconsidered using a computational modeling approach. As suggested by previous research, control of gaze holding is assumed to be enhanced by the floccular lobe, whereas control of the saccadic pulse is governed by the oculomotor vermi...

journal_title：Annals of the New York Academy of Sciences

authors： Glasauer S

更新日期：2003-10-01 00:00:00

abstract：:We created a toolbox of recombinant, microbial lipases, which allows us in combination with a lipase database to choose among the overexpressed lipases the most appropriate for a specific application and to improve it further via mutagenesis. By systematic comparison of geometry and properties of the scissile fatty ac...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt-Dannert C,Pleiss J,Schmid RD

更新日期：1998-12-13 00:00:00

abstract：:Peripheral sympathetic nerve terminals in many tissues, but not all, are endowed with beta-adrenoceptors. Activation of these result in an enhancement of noradrenaline release evoked by electrical nerve stimulation. These so-called presynaptic beta-adrenoceptors are possibly located on the outer surface of the varicos...

journal_title：Annals of the New York Academy of Sciences

authors： Nedergaard OA,Abrahamsen J

更新日期：1990-01-01 00:00:00

abstract：:Basal phagocytosis of neutrophils, a crucial component of non-specific immunity, is an eminently circadian parameter. In mice and rats, rates of phagocytosis peak in the second half of the dark span. A lipopolysaccharide-induced phagocytic response challenged in this period appears the most significant in amplitude an...

journal_title：Annals of the New York Academy of Sciences

authors： Hriscu ML

更新日期：2005-12-01 00:00:00

abstract：:Inflammation plays a key role in excessive bone loss in conditions such as rheumatoid arthritis and periodontitis. An important paradigm in immunology is that inflammatory factors activate feedback inhibition mechanisms to restrain inflammation and limit associated tissue damage. We hypothesized that inflammatory fact...

journal_title：Annals of the New York Academy of Sciences

authors： Ivashkiv LB,Zhao B,Park-Min KH,Takami M

更新日期：2011-11-01 00:00:00

abstract：:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

journal_title：Annals of the New York Academy of Sciences

authors： Porat S,Simantov R

更新日期：1999-01-01 00:00:00

abstract：:Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...

journal_title：Annals of the New York Academy of Sciences

authors： Márka S

更新日期：2012-07-01 00:00:00

abstract：:Insulin resistance has been recognized as the fundamental underlying metabolic defect in the pathogenesis of metabolic syndrome, a clustering of cardiovascular risk factors such as diabetes, hypertension, dyslipidemia, and obesity. Recent studies established that mitochondrial dysfunction is involved in insulin resist...

journal_title：Annals of the New York Academy of Sciences

authors： Lee HK,Park KS,Cho YM,Lee YY,Pak YK

更新日期：2005-05-01 00:00:00

abstract：:Calcitonin gene-related peptide has been identified by immunocytochemistry within the thymus of fetal through aged adult mice. Calcitonin gene-related peptide positive nerves are observed from embryonic day 17 throughout the lifespan of the mouse. A sparse cell population positive for CGRP is first observed during the...

journal_title：Annals of the New York Academy of Sciences

authors： Bulloch K,McEwen BS,Diwa A,Radojcic T,Hausman J,Baird S

更新日期：1994-11-25 00:00:00

abstract：:The levels of cellular glutathione (GSH) and reactive oxygen species (ROS) simultaneously determined by fluorometric measurement, may provide important information on pro-oxidative and antioxidative balance. The dual effect of quercetin antioxidant and pro-oxidant activity was proposed from different studies. Our stud...

journal_title：Annals of the New York Academy of Sciences

authors： Kim GN,Jang HD

更新日期：2009-08-01 00:00:00

abstract：:Isolation of Coxiella Burnetii in the standard laboratory setting is hazardous; therefore most diagnoses are based on retrospective detection of a rising antibody titer to C. burnetti. As a result, this disease is usually undiagnosed or misdiagnosed. Methods for the rapid detection of C. burnetti have now been develop...

journal_title：Annals of the New York Academy of Sciences

authors： Frazier ME,Mallavia LP,Samuel JE,Baca OG

更新日期：1990-01-01 00:00:00

abstract：:After a complete spinal cord injury (SCI) at the lowest thoracic level (T13), adult cats trained to walk on a treadmill can recover hindlimb locomotion within 2-3 weeks, resulting from the activity of a spinal circuitry termed the central pattern generator (CPG). The role of this spinal circuitry in the recovery of lo...

journal_title：Annals of the New York Academy of Sciences

authors： Martinez M,Rossignol S

更新日期：2013-03-01 00:00:00

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:The genomic era has fueled a rapid emergence of new information at the molecular level with a great potential for developing innovative approaches to detection, risk assessment, and management of oral cancers and premalignant disease. As yet, however, little research has been done on complementary approaches that woul...

journal_title：Annals of the New York Academy of Sciences

authors： Rosin MP,Poh CF,Guillard M,Williams PM,Zhang L,MacaUlay C

更新日期：2007-03-01 00:00:00

abstract：:Bone marrow cells of various animal species and the human produce a group of bioregulatory peptides called myelopeptides (MPs). A highly purified myelopeptide (MP) fraction and some individual molecules have been isolated from the supernatant of the porcine bone marrow cell culture by successive gel chromatography and...

journal_title：Annals of the New York Academy of Sciences

authors： Petrov RV

更新日期：1993-06-23 00:00:00

abstract：:Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to treat ADs, but they place HCV-infected patients at...

journal_title：Annals of the New York Academy of Sciences

authors： Galeazzi M,Bellisai F,Giannitti C,Manganelli S,Morozzi G,Sebastiani GD

更新日期：2007-09-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is primarily a motor disorder, and its pathogenesis is multifactorial. As a consequence, treatment should be able to address the underlying pathophysiology. Proton pump inhibitors (PPIs) are the mainstay of medical therapy for GERD, but these drugs only provide the control of sym...

journal_title：Annals of the New York Academy of Sciences

authors： Scarpignato C,Sloan JA,Wang DH,Hunt RH

更新日期：2020-12-01 00:00:00

abstract：:The sense of smell shows a diminution with age as measured by the University of Pennsylvania Smell Identification Test (UPSIT). To ascertain whether the volumes of the olfactory bulbs and tracts (OBTs) and the temporal lobes (TL) declined in parallel to smell function, we examined 36 individuals from ages 22 to 78 who...

journal_title：Annals of the New York Academy of Sciences

authors： Yousem DM,Geckle RJ,Bilker WB,Doty RL

更新日期：1998-11-30 00:00:00

abstract：:Key elements of tumor development include proliferation, migration, invasiveness, and angiogenesis. Activation of the volume-sensitive organic osmolyte/anion channel (VSOAC) has been suggested to play a role in all of these processes. VSOACs may therefore represent an important therapeutic target in the etiology of ca...

journal_title：Annals of the New York Academy of Sciences

authors： Davies AR,Belsey MJ,Kozlowski RZ

更新日期：2004-12-01 00:00:00

abstract：:R-Apomorphine (APO) the catechol-derived dopamine D1-D2 receptor agonist has been shown to be highly potent iron chelator and radical scavenger and inhibitor of membrane lipid peroxidation in vitro, in vivo and in cell culture employing PC12 cells. Its potency has been compared to the prototype iron chelator desferrio...

journal_title：Annals of the New York Academy of Sciences

authors： Youdim MB,Grünblatt E,Mandel S

更新日期：1999-01-01 00:00:00

abstract：:A human T-T hybridoma was produced, which was a fusion product between and HGPRT-deficient T-cell line, Jurkat 3, and an OKT4+ activated peripheral blood T-cell. The hybrid expressed a receptor for IgM Fc and was negative for IgA Fc. It was shown to produce a factor capable of specifically enhancing IgA production and...

journal_title：Annals of the New York Academy of Sciences

authors： Mayer L,Fu SM,Kunkel HG

更新日期：1983-06-30 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:Whole and nonadherent Peyer's patch cells were shown to present antigen to cloned antigen specific T-cells, albeit less efficiently than spleen cells. Unlike spleen cells, adherent PP cells did not present antigen, and PP lacked cells with classical dendritic morphology. The antigen presenting and MLR-stimulating cell...

journal_title：Annals of the New York Academy of Sciences

authors： Tomasi TB,Barr WG,Challacombe SJ,Curran G

更新日期：1983-06-30 00:00:00

abstract：:Conservation translocation of species varies from restoring historic populations to managing the relocation of imperiled species to new locations. We review the literature in three areas--translocation, managed relocation, and conservation decision making--to inform conservation translocation under changing climates. ...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz MW,Martin TG

更新日期：2013-05-01 00:00:00

abstract：:The effects of rhythmic auditory stimulation (RAS) on gait in adolescents with acquired brain injury (ABI) were investigated. A total of 14 adolescents with ABI were initially recruited, and 12 were included in the final analysis (n = 6 each). They were randomly assigned to the experimental (RAS) or the control (conve...

journal_title：Annals of the New York Academy of Sciences

authors： Kim SJ,Shin YK,Yoo GE,Chong HJ,Cho SR

更新日期：2016-12-01 00:00:00

abstract：:The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the animal reflux-inflammation models for Barrett's esophagus and esophageal adenocarcinoma; genomic/epigenomic analyses; eflornithine-based combinations; the molecular derangements that promote neoplastic transforma...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama J,Alexandre L,Baruah A,Buttar N,Chandra R,Clark AB,Hart AR,Hawk E,Kandioler D,Kappel S,Krishnadath SK,Sharma A,Singh I,Straub D,Triadafilopoulos G,Umar A,Wolf B

更新日期：2014-09-01 00:00:00

abstract：:The epidemiologic features are described of cases of human monocytic ehrlichiosis and human granulocytic anaplasmosis in the United States. ...

journal_title：Annals of the New York Academy of Sciences

authors： Demma LJ,Holman RC,McQuiston JH,Krebs JW,Swerdlow DL

更新日期：2006-10-01 00:00:00