Cryptic eco-evolutionary dynamics.

abstract：:A complete amino acid sequence for rat testis P-450 17 alpha was deduced from nucleotide analysis of a cDNA clone isolated from a rat Leydig cell library. This cDNA expressed in COS-1 cells both 17 alpha-hydroxylase and 17,20 lyase activities. Rat P-450 17 alpha exhibited significant similarity to the nucleotide and d...

journal_title：Annals of the New York Academy of Sciences

authors： Dufau ML,Minegishi T,Buczko E,Kitamura M,Delgado C,Namiki M

更新日期：1989-01-01 00:00:00

abstract：:There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wood WG,Eckert GP,Igbavboa U,Müller WE

更新日期：2010-06-01 00:00:00

abstract：:The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...

journal_title：Annals of the New York Academy of Sciences

authors： Klechevsky E,Banchereau J

更新日期：2013-05-01 00:00:00

abstract：:Despite new technological advances in the rehabilitation of audition in profoundly deaf children, auditory training remains a fundamental part of their education. Consequently, it is necessary to learn what kind of stimuli, what kind of auditory tasks, and what kind of learning procedures generate faster and more long...

journal_title：Annals of the New York Academy of Sciences

authors： Rochette F,Bigand E

更新日期：2009-07-01 00:00:00

abstract：:Mouse pheochromocytoma cells (MPCs) provide an excellent model system for investigating the effects of hypoxia on catecholamine enzyme genes and on transcription factors mediating stress responses. RT-PCR detects rapid, transient increases in PNMT mRNA in hypoxic MPC 712 cells. Additionally, elevation of mRNAs encodin...

journal_title：Annals of the New York Academy of Sciences

authors： Evinger MJ,Cikos S,Nwafor-Anene V,Powers JF,Tischler AS

更新日期：2002-10-01 00:00:00

abstract：:Tissue engineering (TE) approaches are being widely investigated for repair of focal defects in articular cartilage. However, the amount and/or type of extracellular matrix (ECM) produced in engineered constructs does not always correlate with the resultant mechanical properties. This could be related to the specifics...

journal_title：Annals of the New York Academy of Sciences

authors： Karchner JP,Querido W,Kandel S,Pleshko N

更新日期：2019-04-01 00:00:00

abstract：:We have used site-directed mutagenesis to investigate the contributions of widely distributed residues in the thymosin beta-4 (Tbeta4) sequence to the formation and stability of the actin-Tbeta4 complex. Equilibrium and kinetic studies of actin binding were performed by monitoring the change in fluorescence of an N-io...

journal_title：Annals of the New York Academy of Sciences

authors： Au JK,De La Cruz EM,Safer D

更新日期：2007-09-01 00:00:00

abstract：:The overarching role of coenzyme Q(10) in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q(10) has a central role acting as a prooxidant in the generation of H(2)O(2). Contrary to the dogma that superoxide and H(2)O(2) formation are highly ...

journal_title：Annals of the New York Academy of Sciences

authors： Linnane AW,Eastwood H

更新日期：2006-05-01 00:00:00

abstract：:This paper describes the experimental results of a pilot-scale application of membrane technologies to textile wastewater advanced treatment, downstream of a biological activated sludge process, aimed at water reuse in textile technology processes. The chosen approach consisted of sand filtration as a pretreatment, a ...

journal_title：Annals of the New York Academy of Sciences

authors： Marcucci M,Ciabatti I,Matteucci A,Vernaglione G

更新日期：2003-03-01 00:00:00

abstract：:The resolution of antibiotic-ribosomal subunit complexes and antibacterial-protein complexes at the atomic level has provided new insights into modifications of clinically relevant antimicrobials and provided new classes that target the protein cellular apparatus. New chemistry platforms that use fragment-based drug d...

journal_title：Annals of the New York Academy of Sciences

authors： Sutcliffe JA

更新日期：2011-12-01 00:00:00

abstract：:In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of ...

journal_title：Annals of the New York Academy of Sciences

authors： Chen BT,Hopf FW,Bonci A

更新日期：2010-02-01 00:00:00

abstract：:The objective of this study was to visualize androgen receptors (ARs) in the testis, epididymis, and prostate of the stallion by means of immunohistochemistry. Nuclear immunostaining was found in all somatic cells in the testis--Leydig, Sertoli, and peritubular myoid cells; in both types of epithelial cells of the epi...

journal_title：Annals of the New York Academy of Sciences

authors： Bilinska B,Hejmej A,Gancarczyk M,Sadowska J

更新日期：2005-04-01 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:Gonad-stimulating substance (GSS) is the first invertebrate gonadotropic neuropeptide hormone identified in a marine invertebrate, the starfish. Here, we show expression and distribution of GSS in various organs of the starfish Asterina pectinifera. Levels of GSS were high in the radial nerves and nerve ring. GSS was ...

journal_title：Annals of the New York Academy of Sciences

authors： Mita M,Ito C,Kubota E,Nagahama Y,Shibata Y

更新日期：2009-04-01 00:00:00

abstract：:There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced...

journal_title：Annals of the New York Academy of Sciences

authors： Rusch HL,Rosario M,Levison LM,Olivera A,Livingston WS,Wu T,Gill JM

更新日期：2019-06-01 00:00:00

abstract：:Learning theory proposes that drug seeking is a synthesis of multiple controllers. Whereas goal-directed drug seeking is determined by the anticipated incentive value of the drug, habitual drug seeking is elicited by stimuli that have formed a direct association with the response. Moreover, drug-paired stimuli can tra...

journal_title：Annals of the New York Academy of Sciences

authors： Hogarth L,Balleine BW,Corbit LH,Killcross S

更新日期：2013-04-01 00:00:00

abstract：:The control of expression of human class II MHC genes has been studied in lymphoid and melanoma cells. Specific unmethylation of all restriction sites nearby the promoter regions has been detected in all cell lines and tissues studied, irrespective of their ability to express class II MHC products. The main functional...

journal_title：Annals of the New York Academy of Sciences

authors： Gambari R,Barbieri R,Piva R,Tecce R,Fisher PB,Giacomini P,Natali PG

更新日期：1987-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) have been defined by their ability to establish long-term hematopoiesis in myelo-ablated hosts. Prospective isolation using combinations of cell-surface markers and/or dye exclusion can yield highly purified and nearly homogeneous phenotypically defined cells that repopulate irradiated h...

journal_title：Annals of the New York Academy of Sciences

authors： Schaniel C,Moore KA

更新日期：2009-09-01 00:00:00

abstract：:The 65-kDa isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes, and most patients have serum antibodies reactive with conformational epitopes on the GAD65 molecule. The aims of this study were to prepare mutants of GAD65 to further localize the type 1 diabetes epitope in the region...

journal_title：Annals of the New York Academy of Sciences

authors： Myers MA,Fenalti G,Gray R,Scealy M,Tong JC,El-Kabbani O,Rowley MJ

更新日期：2003-11-01 00:00:00

abstract：:In this paper, we provide macromolecular comparisons utilizing the 5S ribosomal RNA structure to suggest extant bacteria that are the likely descendants of chloroplast and mitochondria endosymbionts. The genetic stability and near universality of the 5S ribosomal gene allows for a useful means to study ancient evolut...

journal_title：Annals of the New York Academy of Sciences

authors： Delihas N,Fox GE

更新日期：1987-01-01 00:00:00

abstract：:Heart disease is the leading cause of death in the industrialized world. This is partially attributed to the inability of cardiomyocytes to divide in a significant manner, and therefore the heart responds to injury through scar formation. One of the challenges of modern medicine is to develop novel therapeutic strateg...

journal_title：Annals of the New York Academy of Sciences

authors： Bolli P,Chaudhry HW

更新日期：2010-11-01 00:00:00

abstract：:The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

journal_title：Annals of the New York Academy of Sciences

authors： Farries MA

更新日期：2004-06-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:The hypothesis tested was that mutant tumor DNA shed into plasma would show predictive value for monitoring response to therapy in non-small cell lung carcinoma patients. Pretreatment plasma specimens from 25 patients on a phase I trial were evaluated, 12 with paired posttreatment specimens, and 138 patients on the So...

journal_title：Annals of the New York Academy of Sciences

authors： Kimura T,Holland WS,Kawaguchi T,Williamson SK,Chansky K,Crowley JJ,Doroshow JH,Lenz HJ,Gandara DR,Gumerlock PH

更新日期：2004-06-01 00:00:00

abstract：:Clinical and experimental gerontologists are extremely interested in lipoproteins as well as in new methods for investigating and probing the apolipoprotein pattern. Using immunofixation electrophoresis, we separated free apolipoprotein A-1 from the apo A-1 associated with high-density lipoproteins. Free apolipoprotei...

journal_title：Annals of the New York Academy of Sciences

authors： Giunta S,Maddalena-Peruzzi A,Gaudio MR,Semprini A

更新日期：1992-12-26 00:00:00

abstract：:Vestibular stimulation by head accelerations always involves multisensory activation of the vestibular, somatosensory, and visual systems. Over the past few years, galvanic vestibular stimulation (GVS) has become increasingly popular for testing vestibular function for clinical and research purposes. Although GVS prov...

journal_title：Annals of the New York Academy of Sciences

authors： Jahn K,Naessl A,Strupp M,Schneider E,Brandt T,Dieterich M

更新日期：2003-10-01 00:00:00

abstract：:Molecular dynamics (MD) are performed in all-atom simulations of two polymer species based on polythiophene. In one case the amphiphilic polymer forms a monolayer interface between a vacuum and an aqueous layer containing ions. The electroactive nature of the polymer is invoked by conferring a negative charge on it to...

journal_title：Annals of the New York Academy of Sciences

authors： Morton-Blake DA,Leith D

更新日期：2009-04-01 00:00:00

abstract：:Although the evidence for oxidative stress for air pollution in the human lung is fragmentary, the hypothesis that oxidative stress is an important, if not the sole, mechanism of toxicity of oxidizing air pollutants and tobacco smoke is compelling and growing. First, biochemical mechanisms have been worked out for oxi...

journal_title：Annals of the New York Academy of Sciences

authors： Menzel DB

更新日期：1992-09-30 00:00:00

abstract：:The primate orbitofrontal cortex (OFC) is often treated as a single entity, but architectonic and connectional neuroanatomy indicate that it has distinguishable parts. Nevertheless, few studies have attempted to dissociate the functions of its subregions. Here we review findings from recent neuropsychological and neur...

journal_title：Annals of the New York Academy of Sciences

authors： Rudebeck PH,Murray EA

更新日期：2011-12-01 00:00:00

abstract：:Persorption of large, hard, insoluble, solid particles in micrometer size range is observed with regularity. It is a normal biological effect on the food passage through the intestine. Persorbability of particles is determined by the size of the particles and by their consistency and hardness. PVC particles in microme...

journal_title：Annals of the New York Academy of Sciences

authors： Volkheimer G

更新日期：1975-01-31 00:00:00