Immunotoxic effects of cis-urocanic acid exposure in C57BL/6N and C3H/HeN mice.


:Exposure to ultraviolet radiation results in increased levels of intradermal cis-urocanic acid (cUCA) and alters cutaneous immunity by interfering with processing and presentation of antigen by Langerhans cells. Reports on effects of systemic immunotoxicity with 30 day cUCA exposure in laboratory rodents include thymic atrophy, thymic hypocellularity and decreased T-cell-mediated immunity; however, immune effects of single exposure or 5 day cUCA administration, which may better mimic human exposures, are poorly defined. The present study initially evaluated immune effects of single, 5 day, and 4 week cUCA exposure in C57BL/6N mice. Single administration of intradermal cUCA resulted in decreased splenocyte phagocytosis that persisted for 30 days after cUCA exposure. Five day consecutive cUCA exposure decreased numbers of phenotypically mature CD4(+)CD8(-) and CD4(-)CD8(+) (single positive) thymocytes, increased CD4(+)CD8(+) (double positive) immature thymocytes and increased splenocyte proliferation. Prolonged cUCA exposure (4 weeks) caused profound thymic hypocellularity and splenic hypercellularity and increased splenic macrophage chemiluminescence. Because of this apparent sensitivity of C57BL/6N mice to cUCA, thymic hypocellularity was compared between C57BL/6N and C3H/HeN mice dosed with cUCA, and was found to be more pronounced in the C57BL/6N strain. These results are an extension of previous conclusions on immune modulation caused by cUCA in the spleen and thymus. Further, the observed variation in sensitivity between the mouse strains is consistent with known genetic susceptibility of these strains to the immunomodulatory effects of exposure to sunlight.


Photochem Photobiol


Prater MR,Gogal RM Jr,De Fabo EC,Longstreth J,Holladay SD




Has Abstract


2003-04-01 00:00:00












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    abstract::A novel continuous-flow photocatalytic reactor was designed to decompose toluene by using porous nickel sheets that were coated with a Fe-doped TiO2 catalyst. While locating the UV lamp at the central axis, the catalyst sheets were located along the inner wall and positioned vertically with an equal space of 50 mm alo...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Dezhi S,Sheng C,Chung JS,Xiaodong D,Zhibin Z

    更新日期:2005-03-01 00:00:00

  • Chronic ultraviolet B radiation-induced biochemical changes in the skin of hairless mice.

    abstract::Skh:HR-1 hairless mice were irradiated chronically with sub-erythemal doses of UVB radiation, and a number of biochemical parameters in the skin were determined after 6, 12, 18, and 24 wk of exposure. The parameters measured were water, collagen, elastin, and glycosaminoglycan content; collagenase and elastase levels;...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Chatterjee R,Benzinger MJ,Ritter JL,Bissett DL

    更新日期:1990-01-01 00:00:00

  • Comparative analysis of GPCR crystal structures.

    abstract::The phototransduction cascade is perhaps the best understood model system for G protein-coupled receptor (GPCR) signaling. Phototransduction links the absorption of a single photon of light to a decrease in cytosolic cGMP. Depletion of the cGMP pool induces closure of cGMP-gated cation channels resulting in the hyperp...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审


    authors: Lodowski DT,Angel TE,Palczewski K

    更新日期:2009-03-01 00:00:00

  • Fluorescence quantum yields and their relation to lifetimes of rhodamine 6G and fluorescein in nine solvents: improved absolute standards for quantum yields.

    abstract::Absolute fluorescence quantum yields are reported for the rhodamine 6G cation and the fluorescein dianion dyes in nine solvents. This information is combined with previously reported fluorescence lifetimes to deduce radiative and nonradiative decay rates. Along the alcohol series from methanol to octanol, rhodamine 6G...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Magde D,Wong R,Seybold PG

    更新日期:2002-04-01 00:00:00

  • Seasonal variation in measured solar ultraviolet radiation exposure of adults in subtropical Australia.

    abstract::Generating accurate population-specific public health messages regarding sun protection requires knowledge about seasonal variation in sun exposure in different environments. To address this issue for a subtropical area of Australia, we used polysulphone badges to measure UVR for the township of Nambour (26 degrees la...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Neale RE,Hamilton AR,Janda M,Gies P,Green AC

    更新日期:2010-03-01 00:00:00

  • Interaction between human alpha1-acid glycoprotein (orosomucoid) and 2-p-toluidinylnaphthalene-6-sulfonate.

    abstract::The interaction between human alpha1-acid glycoprotein (orosomucoid) and the fluorescent probe, 2-p-toluidinylnaphthalene-6-sulfonate (TNS) has been studied. An association constant of 16.7 (+/- 3) x 10(3) M-1 was obtained for the complex at 20 degrees C with a stoichiometry of 1:1. From the effect of temperature on t...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


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  • Photosensitization with bacteriochlorins.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


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  • Relation of Photochemical Internalization to Heat, pH and Ca2+ Ions.

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    pub_type: 杂志文章


    authors: Soe TH,Nanjo T,Watanabe K,Ohtsuki T

    更新日期:2019-11-01 00:00:00

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


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    更新日期:1999-12-01 00:00:00

  • Time-resolved and steady-state fluorescence spectroscopy of eumelanin and indolic polymers.

    abstract::Eumelanin plays a variety of important physiological roles in human skin. However, its structure and fundamental properties still remain poorly understood. Although the absorbance of eumelanin is broad and reveals little about its structure, a variety of techniques have revealed the presence of a disordered array of c...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Nighswander-Rempel SP,Mahadevan IB,Rubinsztein-Dunlop H,Meredith P

    更新日期:2007-11-01 00:00:00

  • Correlations between reported and measured ultraviolet radiation exposure of mothers and young children.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: O'Riordan DL,Stanton WR,Eyeson-Annan M,Gies P,Roy C

    更新日期:2000-01-01 00:00:00

  • The effects of low density lipoproteins on uptake of Photofrin II.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


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    更新日期:1990-02-01 00:00:00

  • New triruthenium clusters as photoinduced DNA-binding and cleaving agents.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Hwu JR,Kuang-Lieh L,Yu SF,Yu LJ,Kumaresan S,Lin KJ,Tsay SC

    更新日期:2002-05-01 00:00:00

  • Germ Cell Testicular Cancer Incidence, Latitude and Sunlight Associations in the United States and Australia.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Biggar RJ,Baade PD,Sun J,Brandon LE,Kimlin M

    更新日期:2016-09-01 00:00:00

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Ilík P,Kotabová E,Spundová M,Novák O,Kana R,Strzałka K

    更新日期:2010-05-01 00:00:00

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Potter WR,Henderson BW,Bellnier DA,Pandey RK,Vaughan LA,Weishaupt KR,Dougherty TJ

    更新日期:1999-11-01 00:00:00

  • A Photoprotective Effect by Cation-π-Interaction? Quenching of Singlet Oxygen by an Indole Cation-π Model System.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Arevalo GE,Cagan DA,Monsour CG,Garcia AC,McCurdy A,Selke M

    更新日期:2020-11-01 00:00:00

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Alvarez L,Levin CH,Merola F,Bizouarn T,Pasquier H,Baciou L,Rusconi F,Erard M

    更新日期:2010-01-01 00:00:00

  • Somatic-cell mutation induced by UVA and monochromatic UV radiation in repair-proficient and -deficient Drosophila melanogaster.

    abstract::Near-ultraviolet light (UVA: 320-400 nm) constitutes a major part of sunlight UV. It is important to know the effect of UVA on the biological activities of organisms on the earth. We have previously reported that black light induces somatic-cell mutation in Drosophila larvae. To investigate which wavelength of the UVA...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Negishi T,Nagaoka C,Hayatsu H,Suzuki K,Hara T,Kubota M,Watanabe M,Hieda K

    更新日期:2001-05-01 00:00:00

  • Measurements of personal UV exposure on different parts of the body during various activities.

    abstract::Within this study, the erythemal ultraviolet (UV) exposure received by different parts of the body during four different activities is determined. Optoelectronic devices were used to measure the erythemal UV exposure at 10 different positions of the body. The measuring devices were fixed on the forehead, on the should...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Weihs P,Schmalwieser A,Reinisch C,Meraner E,Walisch S,Harald M

    更新日期:2013-07-01 00:00:00

  • Hypocrellin A photosensitization involves an intracellular pH decrease in 3T3 cells.

    abstract::The fluorescent pH probe carboxy-seminaphtorhodafluor-1 (C-Snarf-1) has been used for laser microspectro-fluorometric assays of intracellular pH in 3T3 mouse fibroblasts treated with hypocrellin A. These results are compared to those previously obtained with the structurally related hydroxylated polycyclic quinone, hy...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Chaloupka R,Sureau F,Kocisova E,Petrich JW

    更新日期:1998-07-01 00:00:00

  • Synthesis, spectra and photophysics of some free base tetrafluoroalkyl and tetrafluoroaryl porphyrins with potential applications in imaging.

    abstract::The synthesis, characterization and photophysical properties of two perfluoroalkyl (5,10,15,20-tetrakis-[trifluoromethyl]- and [heptafluoropropyl]-porphyrin) and two perfluoroaryl (5,10,15,20-tetrakis-[2,6-difluorophenyl]- and [pentafluorophenyl]-porphyrin) are described, with reference to their potential in both phot...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Grancho JC,Pereira MM,Miguel Mda G,Rocha GA,Burrows HD

    更新日期:2002-03-01 00:00:00

  • Optical properties of fluorescein-labeled organoclay.

    abstract::We report the preparation of aminopropyl-functionalized magnesium phyllosilicate (Mg-organoclay) conjugated to fluorescein isothiocyanate (FITC) functionality (FITC-organoclay) by one-pot sol-gel synthesis. The physical characteristics of the Mg- and FITC-organoclays were examined by scanning electron microscopy (SEM)...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Lee YC,Lee TH,Han HK,Go WJ,Yang JW,Shin HJ

    更新日期:2010-05-01 00:00:00

  • The crystal structure of the L1 intermediate of halorhodopsin at 1.9 angstroms resolution.

    abstract::The mutant T203V of the light driven chloride pump halorhodopsin from Halobacterium salinarum was crystallized and the X-ray structure was solved at 1.6 angstroms resolution. The T203V structure turned out to be nearly identical to the wild type protein with a root mean square deviation of 0.43 angstroms for the carbo...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Gmelin W,Zeth K,Efremov R,Heberle J,Tittor J,Oesterhelt D

    更新日期:2007-03-01 00:00:00

  • Mutagenesis mediated by triple helix-forming oligonucleotides conjugated to psoralen: effects of linker arm length and sequence context.

    abstract::Targeted mutagenesis and gene knock-out can be mediated by triple helix-forming oligonucleotides (TFO) linked to mutagenic agents, such as psoralen. However, this strategy is limited by the availability of homopurine/homopyrimidine stretches at or near the target site because such sequences are required for high-affin...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Raha M,Lacroix L,Glazer PM

    更新日期:1998-03-01 00:00:00

  • Theoretical investigation of the excited states of 2-nitrobenzyl and 4,5-methylendioxy-2-nitrobenzyl caging groups.

    abstract::The photochemistry of caged compounds of the o-nitrobenzyl type has been investigated thoroughly in the past. However, even recently new side reactions have been discovered. Earlier, we reported [Bley, F., K. Schaper, and H. Görner (2008), Photochem. Photobiol.84 162-171] that we found long-lived triplet states which ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Schaper K,Etinski M,Fleig T

    更新日期:2009-09-01 00:00:00

  • The Anthocyanins, Oenin and Callistephin, Protect RPE Cells Against Oxidative Stress.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Yacout SM,Gaillard ER

    更新日期:2017-03-01 00:00:00

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Vargas F,Canudas N,Miranda MA,Boscá F

    更新日期:1993-10-01 00:00:00

  • Autofluorescence spectroscopy of optically trapped cells.

    abstract::Cellular autofluorescence spectra were monitored in a single-beam gradient force optical trap ("optical tweezers") in order to probe the physiological effects of near infrared and UVA (320-400 nm) microirradiation. Prior to trapping, Chinese hamster ovary cells exhibited weak UVA-excited autofluorescence with maxima a...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: König K,Liu Y,Sonek GJ,Berns MW,Tromberg BJ

    更新日期:1995-11-01 00:00:00

  • Solar UVB and plant damage irradiances for different Argentinean regions.

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    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章


    authors: Micheletti MI,Piacentini RD

    更新日期:2002-09-01 00:00:00