The effects of low density lipoproteins on uptake of Photofrin II.

Abstract:

:The cellular uptake of Photofrin II (PII) was studied using fluorescence imaging and chemical extraction. The influence of serum and low density lipoproteins (LDL) was examined under a variety of experimental conditions employing cultured human cells of different origins as well as a subcutaneously SMT-F tumor implanted in mice. Results showed that serum inhibited PII uptake. In general, LDL also inhibits PII uptake with the exception of an initial increase in the first 10-30 min when the cellular concentration of PII was measured by fluorescence imaging instead of chemical extraction. Our results suggest a possible de-aggregation process occurring upon internalization or binding of PII to LDL.

journal_name

Photochem Photobiol

authors

Korbelik M,Hung J,Lam S,Palcic B

doi

10.1111/j.1751-1097.1990.tb01702.x

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

191-6

issue

2

eissn

0031-8655

issn

1751-1097

journal_volume

51

pub_type

杂志文章
  • Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures.

    abstract::In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and T98G spheroids as shown by flow cytometry on the single cell level. Moreover, cerco is efficiently...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13257

    authors: Grigalavicius M,Mastrangelopoulou M,Arous D,Juzeniene A,Ménard M,Skarpen E,Berg K,Theodossiou TA

    更新日期:2020-05-01 00:00:00

  • Photosensitized reactions of poly(U) with tris(2,2'-bipyridyl)ruthenium(II) and peroxydisulfate.

    abstract::The reactions of polyuridylic acid [poly(U)] with Ru(bpy)3(3+) [Ru(III)] and SO4.-, following UV and visible light irradiation of Ru(bpy)3(2+) [Ru(II)] in the presence of S2O8(2-), were studied in an argon-saturated aqueous solution using time-resolved absorption and conductivity methods. The kinetics of the Ru(III) c...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb04313.x

    authors: Tossi AB,Görner H,Schulte-Frohlinde D

    更新日期:1989-11-01 00:00:00

  • Proton uptake of rhodobacter capsulatus reaction center mutants modified in the primary quinone environment.

    abstract::Flash-induced absorbance spectroscopy was used to analyze the proton uptake and electron transfer properties of photosynthetic reaction centers (RC) of Rhodobacter capsulatus that have been genetically modified near the primary quinone electron acceptor (Q(A)). M246Ala and M247Ala, which are symmetry-related to the po...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2002)075<0126:puorcr>2.0.co;2

    authors: Tandori J,Miksovska J,Valerio-Lepiniec M,Schiffer M,Maróti P,Hanson DK,Sebban P

    更新日期:2002-02-01 00:00:00

  • Novel water-soluble photosensitizer based on starch and containing porphyrin.

    abstract::Novel water-soluble polymeric photosensitizers (SPO) based on starch and containing porphyrin chromophores were synthesized and studied. The polymers were soluble in water and in dimethyl sulfoxide. Photophysical studies and solubilization of molecular probes proved the formation of hydrophobic, rigid microdomains in ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2005-03-07-RA-455

    authors: Nowakowska M,Sterzel M,Zapotoczny S

    更新日期:2005-09-01 00:00:00

  • Photooxidation of tryptophan leading to 2-aminoacetophenone--a possible reason for the untypical aging off-flavor in wine.

    abstract::2-Aminoacetophenone (AAP) was recognized as the key compound for the so-called untypical aging off-flavor (UTA) in Vitis vinifera wines. In this study, it was shown that AAP can be formed by photooxidation of free and protein-bound tryptophan (TRP) in combination with a subsequent storage in model wine. Solutions of T...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12321

    authors: Horlacher N,Schwack W

    更新日期:2014-11-01 00:00:00

  • 8-methoxypsoralen plus UVA induces the 72 kDa heat shock protein in organ-cultured normal human skin.

    abstract::The proteins induced by heat and other stressors, called heat shock proteins (HSP) or stress proteins, are considered to play a general role in protection from cellular injury. Exposure to UVA (320-400 nm) following application of 8-methoxypsoralen (8-MOP), termed PUVA is commonly used in the field of dermatology. In ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb04974.x

    authors: Muramatsu T,Yamashina Y,Tada H,Kobayashi N,Yamaji M,Ohno H,Shirai T,Takahashi A,Ohnishi T

    更新日期:1993-12-01 00:00:00

  • Theoretical Insight into the Emission Properties of the Luciferin and Oxyluciferin of Latia.

    abstract::Latia neritoides is a small limpet-like snail that produces a bright green bioluminescence (BL) via a unique light-emitting system. The process, mechanism, and even light emitter of its light emission remain unknown, although this BL has been known for decades. Unlike the other BL systems, neither the luciferin (Luc) ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12876

    authors: Yu M,Ohmiya Y,Naumov P,Liu YJ

    更新日期:2018-05-01 00:00:00

  • Photosensitizers in dermatology.

    abstract::Systemic injection of hematoporphyrin derivative (HpD) in contribution with visible light (red or blue-green) delivered by laser was used to treat a patient with psoriasis. The psoriatic lesions responded vigorously to laser treatments, forming eschars by 1 week post irradiation. In contrast, only minimal erythema was...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1987.tb04739.x

    authors: McCullough JL,Weinstein GD,Douglas JL,Berns MW

    更新日期:1987-07-01 00:00:00

  • Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature.

    abstract::The temperature dependence of the uptake phase of 5-aminolevulinic acid (ALA) and the following production phase of protoporphyrin IX (PpIX) in normal mouse skin was investigated. A cream containing 20% ALA was topically applied on the skin for 10 min. The amount of ALA-induced PpIX was evaluated by measuring the fluo...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Juzenas P,Sørensen R,Iani V,Moan J

    更新日期:1999-04-01 00:00:00

  • Retarded photooxidation of cyamemazine in biomimetic microenvironments.

    abstract::Cyamemazine (CMZ) is a neuroleptic drug that mediates cutaneous phototoxicity in humans. Here, the photobehavior of CMZ has been examined within α1 -acid glycoproteins, β- and γ-cyclodextrins and SDS micelles. In all these microenvironments, CMZ emission was enhanced and blue-shifted, and its lifetime was longer. Irra...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12303

    authors: Limones-Herrero D,Pérez-Ruiz R,Jiménez MC,Miranda MA

    更新日期:2014-09-01 00:00:00

  • Radical cation generation from singlet and triplet excited states of all-trans-lycopene in chloroform.

    abstract::On direct photoexcitation, subpicosecond time-resolved absorption spectroscopy revealed that the 1B(u)-type singlet excited state of all-trans-lycopene in chloroform was about seven times more efficient than all-trans-beta-carotene in generating the radical cation. The time constant of radical cation generation from t...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2004-04-22-RA-147

    authors: Han RM,Wu YS,Feng J,Ai XC,Zhang JP,Skibsted LH

    更新日期:2004-09-01 00:00:00

  • On the Formation of Thymine Photodimers in Thymine Single Strands and Calf Thymus DNA.

    abstract::Solar light leads to thymine dimers that are mutagenic and primary cause of skin cancer. Here, we report absorption and synchrotron radiation circular dichroism (CD) spectra of Tn single strands with different number n of bases (n = 2-7, 10, 11) recorded after various 254 nm irradiation times. From a principal compone...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12183

    authors: Baggesen LM,Hoffmann SV,Nielsen SB

    更新日期:2014-01-01 00:00:00

  • Effects of short- and long-term ultraviolet B irradiation on the immune system of the common carp (Cyprinus carpio).

    abstract::Carp (Cyprinus carpio) were repeatedly exposed to 0, 60, 120 and 240 mJ/cm2 ultraviolet B (UVB) radiation three times in 1 week (short-term exposure) or 12 times in 4 weeks (long-term exposure). The effect of UVB on the functioning of the carp immune system was studied on day 2 after the final irradiation. After short...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2004-07-13-RA-231

    authors: Markkula SE,Salo HM,Immonen AK,Jokinen EI

    更新日期:2005-05-01 00:00:00

  • Spectroscopic properties of potential sensitizers for new photodynamic therapy start mechanisms via two-step excited electronic states.

    abstract::Three substituted tetraazaporphyrins, octa-(4-tert-butylphenyl)-tetrapyrazinoporphyrazine, tetra-(4-tert-butyl)phthalocyanine and tetra-(4-tert-butyl)phthalocyanatomagnesium(t4-PcMg), were spectroscopically checked in solutions and liposomes with respect to suitability as potential sensitizers of a possible new start ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb02320.x

    authors: Teuchner K,Pfarrherr A,Stiel H,Freyer W,Leupold D

    更新日期:1993-03-01 00:00:00

  • The Xanthophyll Carotenoid Astaxanthin has Distinct Biological Effects to Prevent the Photoaging of the Skin Even by its Postirradiation Treatment.

    abstract::Exposure of human skin to ultraviolet (UV) radiation causes significant damage to that tissue. The effects of UV on the skin mainly include acute inflammation (erythema/edema) and abnormal keratinization wherein prostaglandin E2 (produced by cyclooxygenase-2), interleukin-8 and transglutaminase 1 (a major regulatory f...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/php.13039

    authors: Imokawa G

    更新日期:2019-03-01 00:00:00

  • Constraints of opsin structure on the ligand-binding site: studies with ring-fused retinals.

    abstract::Ring-fused retinal analogs were designed to examine the hula-twist mode of the photoisomerization of the 9-cis retinylidene chromophore. Two 9-cis retinal analogs, the C11-C13 five-membered ring-fused and the C12-C14 five-membered ring-fused retinal derivatives, formed the pigments with opsin. The C11-C13 ring-fused a...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2002)076<0606:coosot>2.0.co;2

    authors: Hirano T,Lim IT,Kim DM,Zheng XG,Yoshihara K,Oyama Y,Imai H,Shichida Y,Ishiguro M

    更新日期:2002-12-01 00:00:00

  • The role of urocanic acid in UV-induced immunosuppression: recent advances (1992-1994).

    abstract::Cis-urocanic acid (UCA), formed in the epidermis by UV irradiation of trans-UCA, has been implicated as a mediator of the immunosuppression induced by UV exposure of the skin. This review covers recent work in which the wavelength dependence of cis-UCA formation, the interaction of UCA isomers with DNA, the effects of...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.1995.tb05261.x

    authors: Norval M,Gibbs NK,Gilmour J

    更新日期:1995-08-01 00:00:00

  • Correlations between reported and measured ultraviolet radiation exposure of mothers and young children.

    abstract::Cumulative and intermittent sun exposure are risk factors for skin cancer, highlighting the need to monitor exposure during childhood. There is currently very little available information concerning the accuracy of self-reported levels of sun exposure, particularly for very young children. In this study, UV radiation ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2000)071<0060:cbramu>2.0.co;2

    authors: O'Riordan DL,Stanton WR,Eyeson-Annan M,Gies P,Roy C

    更新日期:2000-01-01 00:00:00

  • Solvothermal Synthesis of Cs0.33 WO3 /LDHs Composite as a Novel Visible-Light-Driven Photocatalyst.

    abstract::A novel Cs0.33 WO3 /LDHs (CWLDH) composite was synthesized by simple two steps solvothermal method and first investigated as the photocatalyst for tetracycline (TC) and Congo red (CR) degradation under visible light irradiation. The CWLDH heterostructures catalysts were characterized by XRD, UV-Vis, SEM, XPS and BET. ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12838

    authors: Zhang D,Ji T,Yu J,Jiang X,Jiao F

    更新日期:2018-03-01 00:00:00

  • The photochemistry of the retinoids as studied by steady-state and pulsed methods.

    abstract::The retina and retinal pigment epithelium contain a number of retinoids in a metabolic pathway that eventually forms the visual pigments. This study investigates the photochemistry of those retinoids that may contribute to light-induced damage to the retina. These include retinal (RAL), retinol (ROL), retinylpalmitate...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1996.tb05673.x

    authors: Dillon J,Gaillard ER,Bilski P,Chignell CF,Reszka KJ

    更新日期:1996-05-01 00:00:00

  • Effect of oxygen on photoautotrophic and heterotrophic growth of Chlamydomonas reinhardtii in an anoxic atmosphere.

    abstract::Photoautotrophic growth of Chlamydomonas reinhardtii was shown to be independent of the presence of atmospheric oxygen. Under constant light and photoautotrophic conditions, C. reinhardtii grew equally well in either air or 367 PPM CO2-in-He. During 12-h light-dark cycles, the cells in air grew substantially faster th...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1990.tb01803.x

    authors: Graves DA,Spradlin GM,Greenbaum E

    更新日期:1990-09-01 00:00:00

  • Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin.

    abstract::Identification of natural products capable of affording protection against UVB radiation-induced inflammatory responses and generation of oxidative stress may have important human health implications. The UVB exposure-induced skin injury and oxidative stress has been associated with a variety of skin disease condition...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:

    authors: Katiyar SK,Matsui MS,Elmets CA,Mukhtar H

    更新日期:1999-02-01 00:00:00

  • Chronic low-dose UVA irradiation induces local suppression of contact hypersensitivity, Langerhans cell depletion and suppressor cell activation in C3H/HeJ mice.

    abstract::It has previously been demonstrated that chronic low-dose solar-simulated UV radiation could induce both local and systemic immunosuppression as well as tolerance to a topically applied hapten. In this study, we have used a chronic low-dose UV-irradiation protocol to investigate the effects of UVA on the skin immune s...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1996.tb01863.x

    authors: Bestak R,Halliday GM

    更新日期:1996-12-01 00:00:00

  • Development of an in vitro system for the analysis of ultraviolet radiation-induced suppression of natural killer cell activity.

    abstract::Previous studies have shown that natural killer (NK) cell activity was suppressed in volunteer subjects exposed to ultraviolet radiation (UVR) from solarium lamps. The present studies were carried out to determine the spectrum of UVR responsible for suppression of NK activity and to develop in vitro methods to analyze...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb02287.x

    authors: Hersey P,Magrath H,Wilkinson F

    更新日期:1993-02-01 00:00:00

  • The hairless mouse model of photoaging: evaluation of the relationship between dermal elastin, collagen, skin thickness and wrinkles.

    abstract::Quantitative and qualitative changes in dermal collagen and elastin occur in response to chronic ultraviolet (UV) irradiation. These changes have been implicated in the genesis of the wrinkling seen in chronically irradiated, or photoaged skin. We examined the relationship between wrinkle formation and changes in derm...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1992.tb02194.x

    authors: Moloney SJ,Edmonds SH,Giddens LD,Learn DB

    更新日期:1992-10-01 00:00:00

  • Comparative study of photodynamic properties of 13,15-N-cycloimide derivatives of chlorin p6.

    abstract::Comparative study of 13,15-[N-(2-hydroxyethyl)]cycloimide chlorin p6 (2), 13,15-(N-acetoxy)cycloimide chlorin p6 (3), 13,15-(N-hydroxy)cycloimide chlorin p6 methyl ester (4) and 13,15-(N-methoxy)cycloimide chlorin p6 methyl ester (5) together with the previously investigated 13,15-[N-(3-hydroxypropyl)]cycloimide chlor...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2004)079<0172:csoppo>2.0.co;2

    authors: Feofanov A,Sharonov G,Grichine A,Karmakova T,Pljutinskaya A,Lebedeva V,Ruziyev R,Yakubovskaya R,Mironov A,Refregier M,Maurizot JC,Vigny P

    更新日期:2004-02-01 00:00:00

  • Activation of the General Stress Response of Bacillus subtilis by Visible Light.

    abstract::A key challenge for microbiology is to understand how evolution has shaped the wiring of regulatory networks. This is amplified by the paucity of information of power-spectra of physicochemical stimuli to which microorganisms are exposed. Future studies of genome evolution, driven by altered stimulus regimes, will the...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/php.12499

    authors: van der Steen JB,Hellingwerf KJ

    更新日期:2015-09-01 00:00:00

  • Electron transfer quenching of the rose bengal triplet state.

    abstract::The potential for electron transfer quenching of rose bengal triplet (3RB2-) to compete with energy transfer quenching by oxygen was evaluated. Rate constants for oxidative and reductive quenching were measured in buffered aqueous solution, acetonitrile and in small unilamellar liposomes using laser flash photolysis. ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb03133.x

    authors: Lambert CR,Kochevar IE

    更新日期:1997-07-01 00:00:00

  • In vitro photodynamic activity of kryptocyanine.

    abstract::The photophysical properties of 1,1'-diethyl-4,4'-carbocyanine chloride (kryptocyanine) have been measured in methanol solution and for the dye bound to human serum albumin, incorporated in neutral micelles and after incubation with leukemia cells. In all cases, it is found that formation of the triplet state of the d...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1990.tb08674.x

    authors: Harriman A,Luengo G,Gulliya KS

    更新日期:1990-10-01 00:00:00

  • Enhanced UV-B radiation increases glyphosate resistance in velvetleaf (Abutilon theophrasti).

    abstract::Depletion of the ozone layer leads to increasing UV-B radiation on the earth's surface, which may affect weeds and their responses to herbicides. However, the effect of increased UV-B radiation on weeds and the interaction of weeds and herbicides are still obscure. The objective of this study was to compare glyphosate...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01234.x

    authors: Yin L,Zhang M,Li Z,Duan L,Wang S

    更新日期:2012-11-01 00:00:00