Abstract:
:It has previously been demonstrated that chronic low-dose solar-simulated UV radiation could induce both local and systemic immunosuppression as well as tolerance to a topically applied hapten. In this study, we have used a chronic low-dose UV-irradiation protocol to investigate the effects of UVA on the skin immune system of C3H/ HeJ mice. Irradiation with UVA + B significantly suppressed the local and systemic primary contact hypersensitivity (CHS) response to the hapten 2,4,6-trinitrochlorobenzene. Furthermore UVA + B reduced Langerhans cell (LC) and dendritic epidermal T cell (DETC) densities in chronically UV-irradiated mice. Ultraviolet A irradiation induced local, but not systemic, immunosuppression and reduced LC (32%) but not DETC from the epidermis compared to the shaved control animals. Treatment of mice with both UVA + B and UVA radiation also induced an impaired secondary CHS response, and this tolerance was transferable with spleen cells. These results suggest that depletion of LC, but not DETC, may be involved in UVA-induced local immunosuppression in our model, and that tolerance was induced in the presence of normal numbers of DETC. Hence exposure of C3H/HeJ mice 5 days per week for 4 weeks with UVA can induce local immunosuppression and tolerance.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Bestak R,Halliday GMdoi
10.1111/j.1751-1097.1996.tb01863.xsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
969-74issue
6eissn
0031-8655issn
1751-1097journal_volume
64pub_type
杂志文章abstract::The binding interactions of three naphthalimide derivatives with heteropoly nucleic acids have been evaluated using fluorescence, absorption and circular dichroism spectroscopies. Mono- and bifunctionalized naphthalimides exhibit sequence-dependent variations in their affinity toward DNA. The heteropoly nucleic acids,...
journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/php.12478
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pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
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journal_title:Photochemistry and photobiology
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pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1994.tb02981.x
更新日期:1994-05-01 00:00:00