Photosensitization with a chlorin-thiobarbiturate conjugate.

Abstract:

:The photobiologic properties of a chlorin-thiobarbiturate conjugate were examined. In addition to the characteristic 670 nm chlorin absorbance, the conjugate exhibited new absorbance bands at 517 and 743 nm, but these were not a part of the fluorescence emission spectra, nor was fluorescence observed at wavelengths > 670 nm. The action spectrum indicated that the long-wavelength absorbance of the conjugate was not involved in phototoxicity in cell culture, and that only irradiation at wavelengths associated with the chlorin moiety yielded a cytotoxic effect. In vivo cytotoxicity elicited by 745 nm irradiation is attributed to thermal effects.

journal_name

Photochem Photobiol

authors

Kessel D,Morgan A

doi

10.1111/j.1751-1097.1994.tb02981.x

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

547-9

issue

5

eissn

0031-8655

issn

1751-1097

journal_volume

59

pub_type

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