Abstract:
:The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the protein map of the whole cell lysate. Its isoelectric point was 6.4 and the molecular weight was 18,000. This specific protein appeared in maps of the precipitate of 1,000 g centrifugation and in the supernatant from treatment with 0.5% Nonidet P-40 (NP-40). But this specific protein was not stained by five lectins, concanavalin A, wheat germ agglutinin, Ulex europeus agglutinin-1, Dolichis biflorus agglutinin, and Ricinus communis agglutinin. Apparently, this high metastatic potential subline has a specific protein in the plasma membrane which has no glycochain.
journal_name
Oncologyjournal_title
Oncologyauthors
Minato K,Manabe T,Okuyama N,Sasaki Y,Nakagawa K,Saijo Ndoi
10.1159/000227028subject
Has Abstractpub_date
1992-01-01 00:00:00pages
143-6issue
2eissn
0030-2414issn
1423-0232journal_volume
49pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients,...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226836
更新日期:1990-01-01 00:00:00
abstract::Twenty-two evaluable patients with metastatic breast cancer were treated with a combination of 4-(acridinylamino)methanesulfon-m-anisidide (AMSA) and doxorubicin. All patients but one had received prior therapy with fluorouracil, cyclophosphamide, and methotrexate. Eight patients had partial responses (36%) with a med...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226365
更新日期:1986-01-01 00:00:00
abstract::A total of 103 patients with lung cancer was treated with CCNU 130 mg/m2 orally every 6 weeks; 65 patients survived at least 6 weeks. Partial responses occurred in 7 patients. Leukopenia, thrombocytopenia, and nausea were frequent toxic effects. CCNU has slight efficacy in advanced lung cancer. No increase in survival...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225035
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000086972
更新日期:2005-01-01 00:00:00
abstract::In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225828
更新日期:1984-01-01 00:00:00
abstract::We developed a new transcutaneous method for breast cancer detection with dogs: 2 dogs were trained to sniff skin secretion samples on compresses that had been worn overnight by women on their breast, and to recognize a breast cancer sample among 4 samples. During the test, the dogs recognized 90.3% of skin secretion ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492895
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). METHODS:Sixty-eight patients who had advanced HCC with invasion to IHLVs were studied. Thirty-two consecutive pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000120996
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000337232
更新日期:2012-01-01 00:00:00
abstract::We evaluated changes in serum albumin concentrations in 15 patients with advanced malignancy who were also receiving cisplatin. All 15 patients had serial measurements of serum albumin. The decrease in serum albumin from the time of the first dose of cisplatin to death correlated with liver platinum levels at autopsy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226100
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000501340
更新日期:2019-01-01 00:00:00
abstract::The efficacy of recombinant interferon-alpha 2 in the treatment of advanced hairy cell leukaemia is investigated in 31 patients. Preliminary results show a complete and partial response rate of 69%. An optimal dose study utilizing maximal stimulation of an interferon-dependent pathway was carried out in 5 patients. Th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226076
更新日期:1985-01-01 00:00:00
abstract::Ifosfamide is one of the best-known alkylating agents. In advanced epithelial ovarian cancer, it has been tested in association with cisplatin, achieving results equal, if not better than cyclophosphamide, with acceptable toxicity. In second-line therapy, it shows remarkable activity, even in patients refractory to ci...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000073361
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000489217
更新日期:2018-01-01 00:00:00
abstract::Eleven postmenopausal patients with advanced breast cancer were assessed for their response and endocrine changes to low-dose aminoglutethimide (250 mg twice a day) therapy without steroid administration. In 7 cases an objective response was registered; 1 patient had a stabilization of the disease lasting for 9 months...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227006
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477405
更新日期:2017-01-01 00:00:00
abstract::Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227317
更新日期:1994-01-01 00:00:00
abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226444
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000322189
更新日期:2010-01-01 00:00:00
abstract::A demonstration multiphasic cancer screening program was conducted in a rural village in Thailand under the coordination of Bangkok's National Cancer Institute. The village's physician, mayor, and other members of the community assumed a variety of volunteer roles in order to provide logistical support. In short, this...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226029
更新日期:1985-01-01 00:00:00
abstract::The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227741
更新日期:1997-01-01 00:00:00
abstract::Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000065064
更新日期:2002-01-01 00:00:00
abstract::An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227559
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000209963
更新日期:2009-01-01 00:00:00
abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011932
更新日期:1999-01-01 00:00:00
abstract::After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cul...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225478
更新日期:1980-01-01 00:00:00
abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227550
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000481241
更新日期:2017-01-01 00:00:00
abstract::Gastric epithelial cells, identified in biopsy specimens from individuals with varying degrees of gastritis and cellular atypia, were classified according to morphology and reactivity with an adult tissue-absorbed rabbit antibody to 2nd trimester human fetal tissue. Sections of stomach from normal individuals and pati...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225796
更新日期:1984-01-01 00:00:00
abstract::Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258494
更新日期:2009-01-01 00:00:00
abstract:AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111097
更新日期:2007-01-01 00:00:00