Ifosfamide in the treatment of malignant epithelial ovarian tumors.

abstract：:The effects of theophylline treatment on mouse B-16 melanoma cell growth, metabolism, and membrane antigen expression in vitro were studied. Theophylline treatment inhibited DNA synthesis and the cell growth rate, and caused an elevation of intracellular cAMP levels. Cells treated with theophylline became elongated an...

journal_title：Oncology

authors： Kolb CA,Mansfield JM

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...

journal_title：Oncology

authors： Nakamura M,Ishida E,Shimada K,Nakase H,Sakaki T,Konishi N

更新日期：2006-01-01 00:00:00

abstract：:Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every 4 weeks (CAP-1). The results after a median follow-up of 62 mon...

journal_title：Oncology

authors： Wils JA

更新日期：1990-01-01 00:00:00

abstract：:Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...

journal_title：Oncology

authors： Hsu CH,Yeh KH,Chen LT,Liu JM,Jan CM,Lin JT,Chen YC,Cheng AL

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：:14 patients developed acute nonlymphocytic leukemia and 1 patient developed Burkitt's leukemia following longterm chemotherapy and/or radiotherapy for other disorders. The main primary disorders included multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma and breast carcinoma. Acute leukemia developed earlier ...

journal_title：Oncology

authors： Brenner B,Carter A,Sharon R,Tatarsky I

更新日期：1984-01-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid mediator and acts by binding to a specific G-protein-coupled receptor. Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the de...

journal_title：Oncology

authors： Kitagawa D,Taketomi A,Kayashima H,Kuroda Y,Itoh S,Yamashita Y,Maehara Y

更新日期：2007-01-01 00:00:00

abstract：:Three lung tumor-associated markers (LTAM), previously identified as a Cohn Fraction IV alpha-globulin (LTAM-1), ferritin (LTAM-2) and lactoferrin (LTAM-3) were separated by a combination of ion exchange, dye-affinity and molecular sieve chromatography. They were further purified by polyacrylamide gel electrophoresis ...

journal_title：Oncology

authors： Maxim PE,Veltri RW,Sprinkle PM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...

journal_title：Oncology

authors： Sobrero A,Ackland S,Clarke S,Perez-Carrión R,Chiara S,Gapski J,Mainwaring P,Langer B,Young S,AVIRI Trial investigators.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...

journal_title：Oncology

authors： González-González L,González-Ramírez R,Flores A,Avelino-Cruz JE,Felix R,Monjaraz E

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...

journal_title：Oncology

authors： Güth U,Elfgen C,Montagna G,Schmid SM

更新日期：2019-01-01 00:00:00

abstract：:Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...

journal_title：Oncology

authors： Ahlbrandt J,Lablans M,Glocker K,Stahl-Toyota S,Maier-Hein K,Maier-Hein L,Ückert F

更新日期：2020-01-01 00:00:00

abstract：:Lonidamine alone or in combination with hyperthermic perfusion, with or without melphalan, was investigated in 12 patients with stage II, III, and IV malignant melanoma. The authors evaluated the most effective methods and sequence of Lonidamine administration. Preliminary results suggest that the highest effectivenes...

journal_title：Oncology

authors： Cavaliere R,Di Filippo F,Varanese A,Carlini S,Calabro A,Aloe L,Piarulli L

更新日期：1984-01-01 00:00:00

abstract：:The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...

journal_title：Oncology

authors： Jelić S,Kovcin V,Jovanović V,Oprić M,Milanović N

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...

journal_title：Oncology

authors： Magné N,Fischel JL,Formento P,Etienne MC,Dubreuil A,Marcié S,Lagrange JL,Milano G

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...

journal_title：Oncology

authors： Tanaka T,Kuzuya T,Ishigami M,Ito T,Ishizu Y,Honda T,Ishikawa T,Fujishiro M

更新日期：2020-01-01 00:00:00

abstract：:In a registry of 24,105 cancers, 15 patients were found to have three primary cancers in different organs. Decreasing time intervals between sequential diagnoses and then death were noted. Occurrence and sequence of cancer sites appeared to be random. Stage of second and third cancers tended, on the average, to be mor...

journal_title：Oncology

authors： Holmes FF,Cole PA Jr

更新日期：1975-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS). METHODS:Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests. RESU...

journal_title：Oncology

authors： Loizzi V,Cormio G,Nestola D,Falagario M,Surgo A,Camporeale A,Putignano G,Selvaggi L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...

journal_title：Oncology

authors： Hess V,Herrmann R,Veelken H,Schwabe M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...

journal_title：Oncology

authors： Ho HS

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...

journal_title：Oncology

authors： Shirono T,Iwamoto H,Niizeki T,Shimose S,Nakano M,Satani M,Okamura S,Noda Y,Kamachi N,Kuromatsu R,Sakai M,Nomiyama M,Kuwano T,Tanaka M,Koga H,Torimura T

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...

journal_title：Oncology

authors： Ogawa C,Morita M,Omura A,Noda T,Kubo A,Matsunaka T,Tamaki H,Shibatoge M,Tsutsui A,Senoh T,Nagano T,Takaguchi K,Tani J,Morishita A,Yoneyama H,Masaki T,Moriya A,Ando M,Deguchi A,Kokudo Y,Minami Y,Ueshima K,Sakur

更新日期：2017-01-01 00:00:00

abstract：:In 12 patients with gastric cancer and in 14 with large bowel neoplasia, classified according to the TNM system, some major blood indices of hemostasis, platelet activation and fibrinolysis were assessed before and for 1 month after surgery, to show whether possible variations of such indices may provide useful clues ...

journal_title：Oncology

authors： Abbasciano V,Guerra S,Reali MG,Guglielmini C

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of th...

journal_title：Oncology

authors： Muindi JR,Modzelewski RA,Peng Y,Trump DL,Johnson CS

更新日期：2004-01-01 00:00:00

abstract：:Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the freq...

journal_title：Oncology

authors： Gundy S,Baki M,Bodrogi I,Czeizel A

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Low body mass index (BMI) and/or low lean body mass have been shown to be risk factors for chemotherapy-related toxicities in a number of different cancers. However, no data are available regarding the role of BMI as a risk factor for developing toxicities related to the novel anticancer agent, trabectedin, ...

journal_title：Oncology

authors： Vincenzi B,Badalamenti G,Armento G,Silletta M,Spalato Ceruso M,Catania G,Napolitano A,Maltese G,Valeri S,Incorvaia L,Santini D,Tonini G

更新日期：2018-01-01 00:00:00

abstract：:This paper presents clinical observations on 130 patients with carcinoma of the pancreas, including 19 with periampullary cancer, the first large study of this disease in Iraq. All of the patients were admitted to the First (one of three) Surgical Unit of the University of Baghdad Teaching Hospital (the Medical City) ...

journal_title：Oncology

authors： Al-Bahrani ZR,Al-Mondhiry HA,Al-Saleem T

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...

journal_title：Oncology

authors： Ahn HK,Uhm JE,Lee J,Lim DH,Seo SW,Sung KS,Lee SJ,Lee DJ,Baek KK,Kim WS,Park JO

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:In order to broaden the possibility for anti-MAGE-3 immune targeting, it is important to identify HLA-A24-restricted epitopes derived from MAGE-3, since HLA-A24 is one of the most common alleles in Japanese and Asian people. In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presente...

journal_title：Oncology

authors： Miyagawa N,Kono K,Mimura K,Omata H,Sugai H,Fujii H

更新日期：2006-01-01 00:00:00