Acute leukemia following chemotherapy and radiation therapy--a report of 15 cases.

abstract：OBJECTIVES:The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS:Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer ...

journal_title：Oncology

authors： Kitamura S,Tanahashi T,Aoyagi E,Nakagawa T,Okamoto K,Kimura T,Miyamoto H,Mitsui Y,Rokutan K,Muguruma N,Takayama T

更新日期：2017-01-01 00:00:00

abstract：:Eleven postmenopausal patients with advanced breast cancer were assessed for their response and endocrine changes to low-dose aminoglutethimide (250 mg twice a day) therapy without steroid administration. In 7 cases an objective response was registered; 1 patient had a stabilization of the disease lasting for 9 months...

journal_title：Oncology

authors： Kahán Z,Tóth I,Vecsernyés M

更新日期：1992-01-01 00:00:00

abstract：:Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...

journal_title：Oncology

authors： Mimori K,Matsuyama A,Yoshinaga K,Yamashita K,Masuda T,Inoue H,Ueo H,Mori M

更新日期：2002-01-01 00:00:00

abstract：:362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...

journal_title：Oncology

authors： Fountzilas G,Polichronis A,Katsohis K,Gennatas K,Toussis D,Skarlos D,Kosmidis P,Vassilaros S,Semoglou C,Giannakakis T,Fahantidis E,Klouvas G,Tsavaris N,Konstantaras C,Makrantonakis P,Kolotas C,Zamboglou N,Tsiliakos S,

更新日期：1996-03-01 00:00:00

abstract：:Aromatase inhibitor (AI) is widely used as an endocrine treatment in postmenopausal patients with hormone receptor-positive breast cancer. To identify useful prognostic factors for patients with metastatic breast cancer treated with AI therapy, we investigated the association between several hormone receptor-related f...

journal_title：Oncology

authors： Motomura K,Ishitobi M,Komoike Y,Koyama H,Nagase H,Inaji H,Noguchi S

更新日期：2010-01-01 00:00:00

abstract：:Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...

journal_title：Oncology

authors： Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：:Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the comp...

journal_title：Oncology

authors： Sur B,Chatterjee SP,Sur P,Maity T,Roychoudhury S

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...

journal_title：Oncology

authors： Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

更新日期：2003-01-01 00:00:00

abstract：:This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions an...

journal_title：Oncology

authors： Sone S,Ogura T

更新日期：1994-03-01 00:00:00

abstract：:Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...

journal_title：Oncology

authors： Amadori A,Rossi E,Zamarchi R,Carli P,Pastorelli D,Jirillo A

更新日期：2009-01-01 00:00:00

abstract：:The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic ac...

journal_title：Oncology

authors： Kudo M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

journal_title：Oncology

authors： Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：:Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...

journal_title：Oncology

authors： Klastersky J

更新日期：2003-01-01 00:00:00

abstract：:Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...

journal_title：Oncology

authors： Latner AL,Turner GA,Lamin MM

更新日期：1976-01-01 00:00:00

abstract：:6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...

journal_title：Oncology

authors： Sikorowa L,Morawski A,Piatkowski Z

更新日期：1979-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix. In the majority of cases, HPV proteins E6 and E7 are continuously expressed and bind a variety of cellular proteins. The precise mechanism of HPV-induced carcinogenesis has not been fully elucidated; there...

journal_title：Oncology

authors： Yaginuma Y,Yoda K,Ogawa K

更新日期：2010-01-01 00:00:00

abstract：:The chemosensitivities of 62 human colon cancer tissues, 67 rectal cancer tissues and 31 tumor-adjacent normal mucosal tissues were determined using the in vitro succinate dehydrogenase inhibition (SDI) test. These tissues obtained at the time of surgery were exposed to carboquone (CQ), adriamycin (ADM), mitomycin C (...

journal_title：Oncology

authors： Ueo H,Maehara Y,Saito A,Sakaguchi Y,Kohnoe S,Sugimachi K

更新日期：1991-01-01 00:00:00

abstract：:A sulfur-containing amino acid compound, S-allyl cysteine (SAC), derived from garlic extract inhibited proliferation of nine human and murine melanoma cell line in a dose-dependent manner (1.2-10 mM) assessed by a [3H]thymidine incorporation assay. Three control human lymphoblastoid cell lines were not inhibited by SA...

journal_title：Oncology

authors： Takeyama H,Hoon DS,Saxton RE,Morton DL,Irie RF

更新日期：1993-01-01 00:00:00

abstract：:Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients,...

journal_title：Oncology

authors： Benedetti Panici P,Scambia G,Greggi S,Salerno G,Cento R,Mancuso S

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...

journal_title：Oncology

authors： Saridaki Z,Bozionelou V,Kentepozidis N,Kotsakis A,Vardakis N,Kalykaki A,Gioulbasanis I,Karampeazis A,Vamvakas L,Georgoulias V,Mavroudis D

更新日期：2007-01-01 00:00:00

abstract：:Nicotinamide, the amide derivative of vitamin B(3), cooperates with retinoic acid (RA), a form of vitamin A, and 1,25-dihydroxyvitamin D(3) (D3), to regulate cell differentiation and proliferation of human myeloblastic leukemia cells. In human myeloblastic leukemia cells, RA or D3 are known to cause MAPK signaling lea...

journal_title：Oncology

authors： Shen M,Yen A

更新日期：2009-01-01 00:00:00

abstract：:Small quantities of carcinogens, dl-ethionine, thiotepa, actinomycin D, and 1-(2-chloroethyl-3-cyclohexyl)-1-nitrosourea (CCNU) stimulated in vitro deoxyribonucleic acid (DNA) synthesis of the slime mutant of Neurospora crassa, while there was practically no effect on the DNA from the normal wild type 74A strain. All ...

journal_title：Oncology

authors： Beljanski M,Dutta SK

更新日期：1987-01-01 00:00:00

abstract：:Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...

journal_title：Oncology

authors： Lee HC

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...

journal_title：Oncology

authors： Zhang X,Deng HX,Zhao X,Su D,Chen XC,Chen LJ,Wei YQ,Zhong Q,Li ZY,He X,Yi T

更新日期：2009-01-01 00:00:00

abstract：:Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...

journal_title：Oncology

authors： Eek R,Falkson G

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND/AIMS:The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP...

journal_title：Oncology

authors： Ulusoy G,Adali O,Tumer TB,Sahin G,Gozdasoglu S,Arinç E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:It is well recognized that distinguishing benign from malignant papillary lesions of the breast may pose challenging diagnostic problems. To prospectively evaluate the potential role of mammography, ultrasound and image-guided core biopsy in the diagnosis of papillary lesions of the breast. METHODS:1,442 wo...

journal_title：Oncology

authors： Puglisi F,Zuiani C,Bazzocchi M,Valent F,Aprile G,Pertoldi B,Minisini AM,Cedolini C,Londero V,Piga A,Di Loreto C

更新日期：2003-01-01 00:00:00

abstract：:The immunodepressive effect of a single, carcinogenic dose of dimethylnitrosamine was tested in a potent model of renal cancer induction using two antigens which differ in their cellular processing. Responsiveness to sheep red blood cells (SRBC), an antigen requiring the collaboration of both thymus-dependent (T) and ...

journal_title：Oncology

authors： Hard GC

更新日期：1981-01-01 00:00:00