解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000510691
更新日期:2020-10-14 00:00:00
abstract:PURPOSE:Preclinical studies indicated that imatinib may have single-agent activity in glioblastoma through inhibition of tyrosine kinase activity and also that it might enhance the efficacy of radiotherapy. We therefore sought to investigate clinical efficacy in patients with newly diagnosed and recurrent glioblastoma ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502483
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000506135
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The Oncotype DX Breast Cancer Assay is a 21-gene assay used to predict the likelihood of distant recurrence and the benefit of chemotherapy in patients with node-negative, tamoxifen-treated breast cancer. Prior studies demonstrated 7-19% discordance, or a difference between the recurrence score (RS) and tumo...
journal_title:Oncology
pub_type: 新闻
doi:10.1159/000504965
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508688
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Anthracycline is used to treat various types of cancer; however, cardiotoxicity negatively affects patient prognosis. OBJECTIVES:The aim of the present study was to investigate serial changes in levels of cardiac troponin I (TnI) and B-type natriuretic peptide (BNP) in patients treated with anthracycline-co...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507585
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502910
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS:We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at...
journal_title:Oncology
pub_type: 新闻
doi:10.1159/000509434
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507051
更新日期:2020-01-01 00:00:00
abstract::Information technology (IT) can enhance or change many scenarios in cancer research for the better. In this paper, we introduce several examples, starting with clinical data reuse and collaboration including data sharing in research networks. Key challenges are semantic interoperability and data access (including data...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000493638
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Circulating tumor cells (CTCs) have been identified and shown to have prognostic and predictive roles in several types of carcinoma. More recently, aneuploid CTCs have become subject of a growing interest, as aneuploidy is considered a hallmark of cancer often associated with poor prognosis. Here, we aimed t...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000509326
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507118
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate clinicopathological responses and oncological outcome in patients receiving short- or long-course chemoradiotherapy (CRT) and to assess the predictive factor for recurrence in each treatment. METHODS:A total of 118 rectal cancer patients receiving preoperative CRT were enrolle...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492617
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492822
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500885
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The survival rate of patients with lung cancer has increased significantly over the years, but there has been no further progress in third- or fourth-line therapy. We investigated the efficacy and tolerability of monotherapy with weekly vinorelbine, a semi-synthetic vinca alkaloid, in advanced non-small-cell...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502343
更新日期:2019-01-01 00:00:00
abstract::We developed a new transcutaneous method for breast cancer detection with dogs: 2 dogs were trained to sniff skin secretion samples on compresses that had been worn overnight by women on their breast, and to recognize a breast cancer sample among 4 samples. During the test, the dogs recognized 90.3% of skin secretion ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492895
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000501802
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). METHODS:Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyz...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492597
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000493427
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000497184
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000501340
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500298
更新日期:2019-01-01 00:00:00
abstract::Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combinatio...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000488861
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Low body mass index (BMI) and/or low lean body mass have been shown to be risk factors for chemotherapy-related toxicities in a number of different cancers. However, no data are available regarding the role of BMI as a risk factor for developing toxicities related to the novel anticancer agent, trabectedin, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487266
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487081
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease after cytoreduction. M...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000486788
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply in...
journal_title:Oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000486338
更新日期:2018-01-01 00:00:00
abstract::Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000485322
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000489217
更新日期:2018-01-01 00:00:00
abstract::We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478660
更新日期:2017-01-01 00:00:00
abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000478703
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477405
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477173
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS:NAC prior to curative treatmen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000455128
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS:Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000464329
更新日期:2017-01-01 00:00:00
abstract::Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit c...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000454953
更新日期:2017-01-01 00:00:00
abstract::Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was performed in a patient with unresectable pancreatic cancer who developed pancreatitis. In this case, EUS-PD was useful as salvage therapy for pancreatitis as the transpapillary approach was difficult. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000481238
更新日期:2017-01-01 00:00:00