Side effects of ifosfamide.

abstract：OBJECTIVES:To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). METHODS:Sixty-eight patients who had advanced HCC with invasion to IHLVs were studied. Thirty-two consecutive pa...

journal_title：Oncology

authors： Nakazawa T,Adachi S,Kitano M,Isobe Y,Kokubu S,Hidaka H,Ono K,Okuwaki Y,Watanabe M,Shibuya A,Saigenji K

更新日期：2007-01-01 00:00:00

abstract：:The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...

journal_title：Oncology

authors： Al-Awadi FM,Al-Bader AA

更新日期：1987-01-01 00:00:00

abstract：:Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...

journal_title：Oncology

authors： Ikeguchi M,Kondou A,Oka A,Tsujitani S,Maeta M,Kaibara N

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...

journal_title：Oncology

authors： Shiina H,Igawa M,Shigeno K,Yamasaki Y,Urakami S,Yoneda T,Wada Y,Honda S,Nagasaki M

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis in tumor-derived m...

journal_title：Oncology

authors： Flynn G,Chung I,Yu WD,Romano M,Modzelewski RA,Johnson CS,Trump DL

更新日期：2006-01-01 00:00:00

abstract：:This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...

journal_title：Oncology

authors： Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

更新日期：1999-10-01 00:00:00

abstract：:Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...

journal_title：Oncology

authors： Schier S,Wright NA

更新日期：2005-01-01 00:00:00

abstract：:Persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC). One of the characteristics of HCV infection is the unusual augmentation of oxidative stress, which is exacerbated by iron accumulation in the liver, as observed frequently in hepatitis C patients. U...

journal_title：Oncology

authors： Fujinaga H,Tsutsumi T,Yotsuyanagi H,Moriya K,Koike K

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...

journal_title：Oncology

authors： Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

更新日期：2003-01-01 00:00:00

abstract：:An experimental model is introduced for the study of liver metastases using intrasplenically injected EL-4 and Lewis lung tumor cells. Fluorinated pyrimidine derivatives, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil, showed inhibitory effects on the frequencies of liver metastases. Immunosuppressive effects...

journal_title：Oncology

authors： Tsuru S,Shinomiya N,Katsura Y,Gotoh M,Noritake M,Nomoto K

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...

journal_title：Oncology

authors： Kodama H,Aikata H,Uka K,Takaki S,Mori N,Waki K,Jeong SC,Kawakami Y,Shirakawa H,Takahashi S,Toyota N,Ito K,Chayama K

更新日期：2007-01-01 00:00:00

abstract：:From January 1991 to August 1993, 237 women with metastatic breast cancer were recruited into a multicentric phase II clinical trial designed to assess the cardioprotective activity of Cardioxane (ICRF-187). All patients were treated with 5-fluorouracil 500 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2 (FDC)...

journal_title：Oncology

authors： Kolaric K,Bradamante V,Cervek J,Cieslinska A,Cisarz-Filipcak E,Denisov LE,Donat D,Drosik K,Gershanovic M,Hudziec P

更新日期：1995-05-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：:The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...

journal_title：Oncology

authors： Zaglama NE,Rosenblum SL,Sartiano GP,Brady M,Gonzalez MF,Valdivieso JG

更新日期：1986-01-01 00:00:00

abstract：:72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...

journal_title：Oncology

authors： Stolinsky DC,Solomon J,Weiner JM,Bateman JR

更新日期：1976-01-01 00:00:00

abstract：:Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...

journal_title：Oncology

authors： Altavilla G,Carrà L,Alberti S,Corallini A,Cavazzini L,Fabris G,Aleotti A,Barbanti-Brodano G

更新日期：1983-01-01 00:00:00

abstract：:Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...

journal_title：Oncology

authors： Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

journal_title：Oncology

authors： Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

更新日期：2020-01-01 00:00:00

abstract：:Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the freq...

journal_title：Oncology

authors： Gundy S,Baki M,Bodrogi I,Czeizel A

更新日期：1990-01-01 00:00:00

abstract：:Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...

journal_title：Oncology

authors： Mimori K,Matsuyama A,Yoshinaga K,Yamashita K,Masuda T,Inoue H,Ueo H,Mori M

更新日期：2002-01-01 00:00:00

abstract：:In the 2010 version of the Japan Society of Hepatology (JSH) consensus-based treatment algorithm for the management of hepatocellular carcinoma (HCC), transarterial chemoembolization (TACE) failure/refractoriness was defined assuming the use of superselective lipiodol TACE, which has been widely used worldwide and par...

journal_title：Oncology

authors： Kudo M,Matsui O,Izumi N,Kadoya M,Okusaka T,Miyayama S,Yamakado K,Tsuchiya K,Ueshima K,Hiraoka A,Ikeda M,Ogasawara S,Yamashita T,Minami T,Liver Cancer Study Group of Japan.

更新日期：2014-01-01 00:00:00

abstract：:Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...

journal_title：Oncology

authors： Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

更新日期：2017-01-01 00:00:00

abstract：:362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...

journal_title：Oncology

authors： Fountzilas G,Polichronis A,Katsohis K,Gennatas K,Toussis D,Skarlos D,Kosmidis P,Vassilaros S,Semoglou C,Giannakakis T,Fahantidis E,Klouvas G,Tsavaris N,Konstantaras C,Makrantonakis P,Kolotas C,Zamboglou N,Tsiliakos S,

更新日期：1996-03-01 00:00:00

abstract：:To assess the prognostic value of pretreatment serum neuron-specific enolase (NSE) in nonsmall cell lung cancer (NSCLC), levels were measured in 84 NSCLC patients, 40 healthy controls, and 20 patients with benign pulmonary diseases. NSE concentration was higher in NSCLC (11.7 +/- 10.8 ng/ml) (mean +/- SD; median = 9.7...

journal_title：Oncology

authors： Diez M,Torres A,Ortega L,Maestro M,Hernando F,Gomez A,Picardo A,Granell J,Balibrea JL

更新日期：1993-03-01 00:00:00

abstract：:The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...

journal_title：Oncology

authors： Hata H,Hamano M,Watanabe J,Kuramoto H

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...

journal_title：Oncology

authors： Sadahiro S,Suzuki T,Maeda Y,Tanaka A,Ishikawa K,Makuuchi H,Murayama C

更新日期：2009-01-01 00:00:00

abstract：:In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...

journal_title：Oncology

authors： Noberasco C,Bajetta E,Zilembo N,Di Leo A,Cappuzzo F,Bartoli C,Bono A,Bichisao E

更新日期：1995-11-01 00:00:00

abstract：:The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...

journal_title：Oncology

authors： Agúndez JA,Gallardo L,Ledesma MC,Lozano L,Rodriguez-Lescure A,Pontes JC,Iglesias-Moreno MC,Poch J,Ladero JM,Benítez J

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of th...

journal_title：Oncology

authors： Muindi JR,Modzelewski RA,Peng Y,Trump DL,Johnson CS

更新日期：2004-01-01 00:00:00