Abstract:
:This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rates were 55.6% (complete response: 3, partial response: 32, no change: 21, progressive disease: 7/63) and the mean 50% survival was 10.5 months. Most responders died due to the progression of extrahepatic lesions. HAI of the FEM regimen induced a high response rate in patients with hepatic metastases of gastric cancer, and the prognosis-determining factor was the existence of extrahepatic lesions in many patients.
journal_name
Oncologyjournal_title
Oncologyauthors
Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima Kdoi
10.1159/000012034subject
Has Abstractpub_date
1999-10-01 00:00:00pages
216-23issue
3eissn
0030-2414issn
1423-0232pii
12034journal_volume
57pub_type
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