Abstract:
:The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histological types (n = 12) were all negative for proGRP. In addition, serum proGRP levels were elevated in patients with primary or recurrent MTC (n = 3), and they changed in parallel with serum calcitonin (CT), and carcinoembryonic antigen (CEA). These results show that proGRP, which is considered to be a specific marker for small-cell lung carcinoma, may be also a potential tumor marker for MTC, in addition to CT and CEA.
journal_name
Oncologyjournal_title
Oncologyauthors
Inaji H,Komoike Y,Motomura K,Higashiyama M,Ohtsuru M,Funai H,Kasugai T,Koyama Hdoi
10.1159/000012148subject
Has Abstractpub_date
2000-08-01 00:00:00pages
122-5issue
2eissn
0030-2414issn
1423-0232pii
12148journal_volume
59pub_type
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